Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Tanner O Monroe"'
Autor:
Megan J. Puckelwartz, Lorenzo L. Pesce, Edgar J. Hernandez, Gregory Webster, Lisa M. Dellefave-Castillo, Mark W. Russell, Sarah S. Geisler, Samuel D. Kearns, Felix Karthik, Susan P. Etheridge, Tanner O. Monroe, Tess D. Pottinger, Prince J. Kannankeril, M. Benjamin Shoemaker, Darlene Fountain, Dan M. Roden, Meghan Faulkner, Heather M. MacLeod, Kristin M. Burns, Mark Yandell, Martin Tristani-Firouzi, Alfred L. George, Elizabeth M. McNally
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-13 (2024)
Abstract Background Sudden unexpected death in children is a tragic event. Understanding the genetics of sudden death in the young (SDY) enables family counseling and cascade screening. The objective of this study was to characterize genetic variatio
Externí odkaz:
https://doaj.org/article/754c31b062b14f8fb5738e1f18f62142
Autor:
Joyce C. Ohiri, Lisa Dellefave‐Castillo, Garima Tomar, Lisa Wilsbacher, Lubna Choudhury, David Y. Barefield, Dominic Fullenkamp, Anthony M. Gacita, Tanner O. Monroe, Lorenzo Pesce, Malorie Blancard, Lauren Vaught, Alfred L. George, Alexis R. Demonbreun, Megan J. Puckelwartz, Elizabeth M. McNally
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 10 (2024)
Background Many cardiomyopathy‐associated FLNC pathogenic variants are heterozygous truncations, and FLNC pathogenic variants are associated with arrhythmias. Arrhythmia triggers in filaminopathy are incompletely understood. Methods and Results We
Externí odkaz:
https://doaj.org/article/f77896bb0287466494c3807c1849c7e0
Autor:
Tanner O. Monroe, Melanie E. Garrett, Maria Kousi, Ramona M. Rodriguiz, Sungjin Moon, Yushi Bai, Steven C. Brodar, Karen L. Soldano, Jeremiah Savage, Thomas F. Hansen, Donna M. Muzny, Richard A. Gibbs, Lawrence Barak, Patrick F. Sullivan, Allison E. Ashley-Koch, Akira Sawa, William C. Wetsel, Thomas Werge, Nicholas Katsanis
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The role of ciliary/centriolar components in the postnatal brain is unclear. Here, the authors show via ablation of Pcm1 in mice that degenerative ciliary/centriolar phenotypes induce neuroanatomical and behavioral changes. Sequencing of PCM1 in huma
Externí odkaz:
https://doaj.org/article/d5f60ef175b64f618a0d4c6e80cba746
Autor:
Jimmonique Donelson, Qiongling Wang, Tanner O. Monroe, Xiqian Jiang, Jianjie Zhou, Han Yu, Qianxing Mo, Qin Sun, Juan C. Marini, Xinquan Wang, Paul A. Nakata, Kendal D. Hirschi, Jin Wang, George G. Rodney, Xander H.T. Wehrens, Ninghui Cheng
Publikováno v:
Physiological Reports, Vol 7, Iss 8, Pp n/a-n/a (2019)
Abstract Growing evidence suggests that redox‐sensitive proteins including glutaredoxins (Grxs) can protect cardiac muscle cells from oxidative stress‐induced damage. Mammalian Grx3 has been shown to be critical in regulating cellular redox state
Externí odkaz:
https://doaj.org/article/b3c877fa26e2425991ebeb043f67aa6d
Autor:
Megan J. Puckelwartz, Lorenzo L. Pesce, Edgar J. Hernandez, Gregory Webster, Lisa M. Dellefave-Castillo, Mark W. Russell, Sarah S. Geisler, Samuel D. Kearns, Felix K Etheridge, Susan P. Etheridge, Tanner O. Monroe, Tess D. Pottinger, Prince J. Kannankeril, M. Benjamin Shoemaker, Darlene Fountain, Dan M. Roden, Heather MacLeod, Kristin M. Burns, Mark Yandell, Martin Tristani-Firouzi, Alfred L. George, Elizabeth M. McNally
Publikováno v:
medRxiv
BackgroundSudden unexpected death in children is a tragic event. Understanding the genetics of sudden death in the young (SDY) enables family counseling and cascade screening. The objective of this study was to characterize genetic variation in an SD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96f4ded27efef0884af4112da59a6363
https://doi.org/10.1101/2023.03.27.23287711
https://doi.org/10.1101/2023.03.27.23287711
Publikováno v:
Circulation Research. 131
Background: Up to 1% of humans are born with a congenital heart defect. Among those defects is a condition known as left ventricular noncompaction (LVNC), which is defined as the ratio of trabeculated myocardium to compact myocardium exceeding 2.3:1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87cf67c94bd552b5232e91872b6f2636
https://doi.org/10.1161/res.131.suppl_1.p2112
https://doi.org/10.1161/res.131.suppl_1.p2112
Autor:
Julie A Fischer, Tanner O Monroe, Lorenzo L Pesce, Konrad T Sawicki, Mattia Quattrocelli, Rosemary Bauer, Samuel D Kearns, Matthew J Wolf, Megan J Puckelwartz, Elizabeth M McNally
Publikováno v:
Human molecular genetics.
Genetic variation in genes regulating metabolism may be advantageous in some settings but not others. The non-failing adult heart relies heavily on fatty acids as a fuel substrate and source of ATP. In contrast, the failing heart favors glucose as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb08ce51acbd12ff4f7829dd42c9a599
https://pubmed.ncbi.nlm.nih.gov/35904451
https://pubmed.ncbi.nlm.nih.gov/35904451
Autor:
Jong H Kim, Brittany Stork, Tanner O. Monroe, Yongcheng Song, Todd K. Rosengart, Andrea R Ortiz, Bert W. O'Malley, John Leach, Andrew G. Sikora, Poonam Sarkar, M. Waleed Gaber, James F. Martin, Lisa K. Mullany, Clifford C. Dacso, David M. Lonard, Aarti D. Rohira, Brian York
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance We are at an exciting era of identification of the cell and molecular processes necessary for tissue remodeling and repair. Unlike current systemic therapeutics, our studies reveal pharmacologic stimulation of SRCs modulates macrophage a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27922cbc22238a1e561cd521f777b3a3
https://doi.org/10.1073/pnas.2011614117
https://doi.org/10.1073/pnas.2011614117
Autor:
Larry S. Barak, Richard A. Gibbs, Yushi Bai, Maria Kousi, Tanner O. Monroe, Karen Soldano, Jeremiah Savage, Sungjin Moon, Ramona M. Rodriguiz, Steven C. Brodar, Thomas Hansen, Melanie E. Garrett, Donna M. Muzny, Nicholas Katsanis, Akira Sawa, William C. Wetsel, Allison E. Ashley-Koch, Patrick F. Sullivan, Thomas Werge
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Monroe, T O, Garrett, M E, Kousi, M, Rodriguiz, R M, Moon, S, Bai, Y, Brodar, S C, Soldano, K L, Savage, J, Hansen, T F, Muzny, D M, Gibbs, R A, Barak, L, Sullivan, P F, Ashley-Koch, A E, Sawa, A, Wetsel, W C, Werge, T & Katsanis, N 2020, ' PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia ', Nature Communications, vol. 11, no. 1, 5903 . https://doi.org/10.1038/s41467-020-19637-5
Nature Communications
Monroe, T O, Garrett, M E, Kousi, M, Rodriguiz, R M, Moon, S, Bai, Y, Brodar, S C, Soldano, K L, Savage, J, Hansen, T F, Muzny, D M, Gibbs, R A, Barak, L, Sullivan, P F, Ashley-Koch, A E, Sawa, A, Wetsel, W C, Werge, T & Katsanis, N 2020, ' PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia ', Nature Communications, vol. 11, no. 1, 5903 . https://doi.org/10.1038/s41467-020-19637-5
Nature Communications
The neuronal primary cilium and centriolar satellites have functions in neurogenesis, but little is known about their roles in the postnatal brain. We show that ablation of pericentriolar material 1 in the mouse leads to progressive ciliary, anatomic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3604c936ba4054697480716dae7b728
http://link.springer.com/article/10.1038/s41467-020-19637-5
http://link.springer.com/article/10.1038/s41467-020-19637-5
Autor:
Celia Pena Heredia, Ryan Fleischmann, George G. Rodney, Marta L. Fiorotto, David P. Ferguson, Tanner O. Monroe, George E. Taffet
Publikováno v:
The Journal of Physiology. 597:1855-1872
Key points Impaired growth during fetal life can reprogramme heart development and increase the risk for long-term cardiovascular dysfunction. It is uncertain if the developmental window during which the heart is vulnerable to reprogramming as a resu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1f86bd29357388c9a9ce31d4120c53c
https://doi.org/10.1113/jp277637
https://doi.org/10.1113/jp277637