PROSER1 mediates TET2 O-GlcNAcylation to regulate DNA demethylation on UTX-dependent enhancers and CpG islands

Autor: Wojciech Rosikiewicz, Hans-Martin Herz, Beisi Xu, Jesper Christensen, Shondra M. Pruett-Miller, Xiaokang Wang, Yurii Sedkov, Tanner Martinez, Baranda S Hansen, Patrick Schreiner, Kristian Helin

Publikováno v: Wang, X, Rosikiewicz, W, Sedkov, Y, Martinez, T, Hansen, B S, Schreiner, P, Christensen, J, Xu, B, Pruett-Miller, S M, Helin, K & Herz, H M 2022, ' PROSER1 mediates TET2 O-GlcNAcylation to regulate DNA demethylation on UTX-dependent enhancers and CpG islands ', Life Science Alliance, vol. 5, no. 1, e202101228 . https://doi.org/10.26508/lsa.202101228
Life Science Alliance

PROSER1 promotes the interaction between TET2 and the glycosyltransferase OGT to regulate TET2 O-GlcNAcylation and stability on genomic elements that depend on the activity of the MLL3/4 complexes.
DNA methylation at enhancers and CpG islands us

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24d495164cf2c089e2667cb08aeddd7e
https://curis.ku.dk/portal/da/publications/proser1-mediates-tet2-oglcnacylation-to-regulate-dna-demethylation-on-utxdependent-enhancers-and-cpg-islands(e1229671-e466-438b-a0b3-c1913028af81).html

Abstract 3159: CUX1 dosage-dependent regulation of hematopoietic stem and progenitor cells

Autor: Weihan Liu, Stephanie Konecki, Tanner Martinez, Megan McNerney

Publikováno v: Cancer Research. 82:3159-3159

The mechanism by which stem and progenitor cells commit to proliferate, self-renew, or differentiate towards different lineages remains unclear. Understanding this process is essential to decipher both normal tissue development and aberrant different

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e4166354b97c5b1c6036c08461b0ee93
https://doi.org/10.1158/1538-7445.am2022-3159

The histone deacetylase complex MiDAC regulates a neurodevelopmental gene expression program

Autor: Chunliang Li, Hans-Martin Herz, Baisakhi Mondal, Yiping Fan, Hongjian Jin, Satish Kallappagoudar, Monica F. Sentmanat, Tanner Martinez, Shondra M. Pruett-Miller, Yurii Sedkov, Greg J Poet

MiDAC is a recently identified histone deacetylase (HDAC) complex. While other HDAC complexes have been implicated in neurogenesis, the physiological role of MiDAC remains unknown. Here, we show that MiDAC constitutes an important regulator of neural

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b79455ad25c6f020aaabfb5f11a080d8
https://doi.org/10.1101/2020.04.07.029751