Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Tanner, Rathbone"'
Autor:
Ilayda Ates, Callie Stuart, Tanner Rathbone, Mercedes Barzi, Gordon He, Angela M. Major, Vijay Shankar, Rachel A. Lyman, Sidney S. Angner, Trudy F.C. Mackay, Shanthi Srinivasan, Alton Brad Farris, Karl-Dimiter Bissig, Renee N. Cottle
Publikováno v:
Hepatology Communications, Vol 8, Iss 5 (2024)
Background:. We previously demonstrated the successful use of in vivo CRISPR gene editing to delete 4-hydroxyphenylpyruvate dioxygenase (HPD) to rescue mice deficient in fumarylacetoacetate hydrolase (FAH), a disorder known as hereditary tyrosinemia
Externí odkaz:
https://doaj.org/article/bfe468ab97a549e5a155fe6c7c05eae7
Autor:
Tanner, Rathbone, Ilayda, Ates, Lawrence, Fernando, Ethan, Addlestone, Ciaran M, Lee, Vincent P, Richards, Renee N, Cottle
Publikováno v:
The CRISPR Journal. 5:397-409
Adeno-associated virus vectors are the most used delivery method for liver-directed gene editing. Still, they are associated with significant disadvantages that can compromise the safety and efficacy of therapies. Here, we investigate the effects of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca50918932776000c162a4a370e9d69e
https://doi.org/10.1089/crispr.2021.0134
https://doi.org/10.1089/crispr.2021.0134
Publikováno v:
Journal of visualized experiments : JoVE. (184)
This protocol describes a fast and effective method for isolating primary mouse hepatocytes followed by electroporation-mediated delivery of CRISPR-Cas9 as ribonucleoproteins (RNPs) and mRNA. Primary mouse hepatocytes were isolated using a three-step
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60c778bf47cf9347d389b891e071a648
https://pubmed.ncbi.nlm.nih.gov/35723482
https://pubmed.ncbi.nlm.nih.gov/35723482
Publikováno v:
Genes, Vol 11, Iss 1113, p 1113 (2020)
Genes
Genes
Impressive therapeutic advances have been possible through the advent of zinc-finger nucleases and transcription activator-like effector nucleases. However, discovery of the more efficient and highly tailorable clustered regularly interspaced short p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad287b1a367fbea6c7f8423d28348f37
https://doi.org/10.3390/genes11101113
https://doi.org/10.3390/genes11101113