Výsledky vyhledávání - "Tanmay Sapre"

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Autor: Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Publikováno v: Mol Cell

Dynamic changes in protein-protein interaction (PPI) networks underlie all physiological cellular functions and drive devastating human diseases. Profiling PPI networks can, therefore, provide critical insight into disease mechanisms and identify new

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51b0bee891eb850ee4f40b78a7f7e012
https://europepmc.org/articles/PMC10072906/

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Neurodevelopmental disorder–associated mutations in TAOK1 reveal its function as a plasma membrane remodeling kinase

Autor: Neal Beeman, Tanmay Sapre, Shao-En Ong, Smita Yadav

Publikováno v: Sci Signal

Mutations in TAOK1 , which encodes a serine-threonine kinase, are associated with both autism spectrum disorder (ASD) and neurodevelopmental delay (NDD). Here, we investigated the molecular function of this evolutionarily conserved kinase and the mec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3c3673a14d0c2329277906319920298
https://doi.org/10.1126/scisignal.add3269

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Neurodevelopmental disorder associated mutations in TAOK1 reveal its function as a plasma membrane remodeling kinase

Autor: Neal Beeman, Tanmay Sapre, Shao-En Ong, Smita Yadav

Mutations in TAOK1, a serine-threonine kinase encoding gene are strongly associated with both autism spectrum disorder (ASD) and neurodevelopmental delay (NDD). However, molecular function of this evolutionarily conserved kinase and the mechanisms th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::837151f8871c7148afc9d70b1b6a389f
https://doi.org/10.1101/2022.07.06.499025

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Multiplexed profiling of kinase interactomes quantifies cellular network plasticity

Autor: Andrea Lius, Martin Golkowski, Ho-Tak Lau, Shao En Ong, Dustin J. Maly, Tanmay Sapre, Taylor Moreno

Cells utilize protein-protein interaction (PPI) networks to receive, transduce, and respond to stimuli. Interaction network rewiring drives devastating diseases like cancers, making PPIs attractive targets for pharmacological intervention. Kinases ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::57f0af0ddbe244055db5536b635945e6
https://doi.org/10.1101/2021.09.14.460283

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