Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Tanja Sgraja"'
Autor:
Rudi Marquez, Victoria Illarionova, Murray N. Robertson, Magnus S. Alphey, Tanja Sgraja, William N. Hunter, Felix Rohdich, Stephanos Ghilagaber, Susan Lauw, Adelbert Bacher, Jennifer L. Hemmings, Wolfgang Eisenreich
Publikováno v:
FEBS Journal. 275:2779-2794
4-Diphosphocytidyl-2C-methyl-d-erythritol kinase (IspE) catalyses the ATP-dependent conversion of 4-diphosphocytidyl-2C-methyl-d-erythritol (CDPME) to 4-diphosphocytidyl-2C-methyl-d-erythritol 2-phosphate with the release of ADP. This reaction occurs
Autor:
Anna K. H. Hirsch, Susan Lauw, William N. Hunter, Tanja Sgraja, Adelbert Bacher, Christine M. Crane, François Diederich, Wolfgang Eisenreich, Magnus S. Alphey, Felix Rohdich, Victoria Illarionova
Publikováno v:
ChemMedChem, 3(1), 91-101. WILEY-V C H VERLAG GMBH
The enzymes of the non-mevalonate pathway for isoprenoid biosynthesis are attractive targets for the development of novel drugs against malaria and tuberculosis. This pathway is used exclusively by the corresponding pathogens, but not by humans. A se
Publikováno v:
Biochemical and Biophysical Research Communications. 351:695-701
The enzyme S-adenosylmethionine:tRNA ribosyltransferase-isomerase (QueA) is involved in the biosynthesis of the hypermodified tRNA nucleoside queuosine. It is unprecedented in nature as it uses the cofactor S-adenosylmethionine as the donor of a ribo
Publikováno v:
Journal of Biological Chemistry. 278:42369-42376
tRNA-guanine transglycosylase (TGT) catalyzes a post-transcriptional base-exchange reaction involved in the incorporation of the modified base queuine (Q) into the wobble position of certain tRNAs. Catalysis by TGT occurs through a double-displacemen
Publikováno v:
Acta crystallographica. Section F, Structural biology and crystallization communications. 61(Pt 7)
The essential enzyme 2C-methyl-d-erythritol-2,4-cyclodiphosphate (MECP) synthase, found in most eubacteria and the apicomplexan parasites, participates in isoprenoid-precursor biosynthesis and is a validated target for the development of broad-spectr
Publikováno v:
BMC Structural Biology
BMC Structural Biology, Vol 7, Iss 1, p 20 (2007)
BMC Structural Biology, Vol 7, Iss 1, p 20 (2007)
Background Isoprenoid precursor synthesis via the mevalonate route in humans and pathogenic trypanosomatids is an important metabolic pathway. There is however, only limited information available on the structure and reactivity of the component enzym