Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Tanja Schönberger"'
Autor:
Julia Sauer, Agnes A. Steixner-Kumar, Svenja Gabler, Maciej Motyka, Jörg F. Rippmann, Stefan Brosa, Dennis Boettner, Tanja Schönberger, Charlotte Lempp, Vanessa Frodermann, Eric Simon, Oliver Krenkel, Ehsan Bahrami
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Chronic liver diseases, such as non-alcoholic steatohepatitis (NASH)-induced cirrhosis, are characterized by an increasing accumulation of stressed, damaged, or dying hepatocytes. Hepatocyte damage triggers the activation of resident immune cells, su
Externí odkaz:
https://doaj.org/article/8f49c0488c064420b392c7d96dc7899e
Autor:
Matthias J. Düchs, Ramona F. Kratzer, Pablo Vieyra-Garcia, Benjamin Strobel, Tanja Schönberger, Peter Groß, Ghaith Aljayyoussi, Aradhana Gupta, Isabel Lang, Holger Klein, Sandra Martinez Morilla, Stefan Hopf, John Park, Sebastian Kreuz, Matthias Klugmann, Frederik H. Igney
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Hepatocellular carcinoma (HCC) and solid cancers with liver metastases are indications with high unmet medical need. Interleukin-12 (IL-12) is a proinflammatory cytokine with substantial anti-tumor properties, but its therapeutic potential has not be
Externí odkaz:
https://doaj.org/article/d7f68968ee5443eba85a103c30a0af1e
Autor:
Matthias Düchs, Dragica Blazevic, Philipp Rechtsteiner, Cynthia Kenny, Thorsten Lamla, Sarah Low, Jimmy Savistchenko, Manuela Neumann, Ronald Melki, Tanja Schönberger, Birgit Stierstorfer, David Wyatt, Frederik Igney, Thomas Ciossek
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-15 (2023)
Abstract Prion-like transmission of pathology in α-synucleinopathies like Parkinson’s disease or multiple system atrophy is increasingly recognized as one potential mechanism to address disease progression. Active and passive immunotherapies targe
Externí odkaz:
https://doaj.org/article/bfa18d4f4cb54bf398d1a6ddf489f5be
Autor:
Dalia Pakalniškytė, Tanja Schönberger, Benjamin Strobel, Birgit Stierstorfer, Thorsten Lamla, Michael Schuler, Martin Lenter
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Transgenic animals with increased or abrogated target gene expression are powerful tools for drug discovery research. Here, we developed a CRISPR-based Rosa26-LSL-dCas9-VPR mouse model for targeted induction of endogenous gene expression usi
Externí odkaz:
https://doaj.org/article/5f71560143154c38951bffbfbcaeeb5e
Autor:
Jonas Weinmann, Sabrina Weis, Josefine Sippel, Warut Tulalamba, Anca Remes, Jihad El Andari, Anne-Kathrin Herrmann, Quang H. Pham, Christopher Borowski, Susanne Hille, Tanja Schönberger, Norbert Frey, Martin Lenter, Thierry VandenDriessche, Oliver J. Müller, Marinee K. Chuah, Thorsten Lamla, Dirk Grimm
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Adeno-associated virus is the basis of many gene therapies and gene transfer vectors. Here the authors report a pipeline to enable side-by-side comparison of pre-selected capsids in a high throughput manner.
Externí odkaz:
https://doaj.org/article/fcda7a44d2044540880d0f383706efd9
Autor:
Julia F. Söllner, Germán Leparc, Matthias Zwick, Tanja Schönberger, Tobias Hildebrandt, Kay Nieselt, Eric Simon
Publikováno v:
BMC Medical Genomics, Vol 12, Iss 1, Pp 1-12 (2019)
Abstract Background The ability to generate recombinant drug target proteins is important for drug discovery research as it facilitates the investigation of drug-target-interactions in vitro. To accomplish this, the target’s exact protein sequence
Externí odkaz:
https://doaj.org/article/ea1ee743c46f4087b5d52424809c6211
Autor:
Rita Bonfiglio, Filippo Galli, Michela Varani, Manuel Scimeca, Filippo Borri, Sara Fazi, Rosella Cicconi, Maurizio Mattei, Giuseppe Campagna, Tanja Schönberger, Ernest Raymond, Andreas Wunder, Alberto Signore, Elena Bonanno
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 4, p 2028 (2021)
This study aims to develop a reliable and reproducible inflammatory bowel disease (IBD) murine model based on a careful spatial–temporal histological characterization. Secondary aims included extensive preclinical studies focused on the in situ exp
Externí odkaz:
https://doaj.org/article/444079ddca82468493a0ee68c07f8420
Autor:
Anna-Kaisa Rimpelä, Michel Garneau, Katja S. Baum-Kroker, Tanja Schönberger, Frank Runge, Achim Sauer
Publikováno v:
Pharmaceutics, Vol 12, Iss 12, p 1174 (2020)
The rat is a commonly used species in ocular drug research. Detailed methods of separating rat ocular tissues have not been described in literature. To understand the intraocular drug distribution, we developed a robust method for the separation of i
Externí odkaz:
https://doaj.org/article/40c26c3a9cb9433e9e1f974a09ebe070
Autor:
David Heinzmann, Anna Bangert, Anna-Maria Müller, Saskia N I von Ungern-Sternberg, Frederic Emschermann, Tanja Schönberger, Madhumita Chatterjee, Andreas F Mack, Karin Klingel, Reinhard Kandolf, Miroslav Malesevic, Oliver Borst, Meinrad Gawaz, Harald F Langer, Hugo Katus, Gunter Fischer, Andreas E May, Ziya Kaya, Peter Seizer
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0124606 (2015)
Cyclophilins are a group of highly conserved cytosolic enzymes that have a peptidylprolyl cis/trans isomerase activity. Cyclophilin A (CyPA) can be secreted in the extracellular space by inflammatory cells and upon cell death. The presence of CyPA in
Externí odkaz:
https://doaj.org/article/440cc1ea6f344efc967edec434a9f492
Autor:
Thomas Wurster, Catharina Pölzelbauer, Tanja Schönberger, Angela Paul, Peter Seizer, Konstantinos Stellos, Andreas Schuster, Rene M Botnar, Meinrad Gawaz, Boris Bigalke
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33602 (2012)
BACKGROUND: Human Parvovirus B19 (PVB19) has been associated with myocarditis putative due to endothelial infection. Whether PVB19 infects endothelial cells and causes a modification of endothelial function and inflammation and, thus, disturbance of
Externí odkaz:
https://doaj.org/article/fecc628ca9844e76b723367ceab100cf