Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Tanja Rossmann-Bloeck"'
Autor:
Heike Weighardt, Bernhard Holzmann, Felicitas Altmayr, Klaus Pfeffer, Klaus-Peter Janssen, Petra Gais, Gabriela Jusek, Daniel Reim, Tanja Rossmann-Bloeck
Publikováno v:
The Journal of Immunology. 188:5833-5837
Although global MyD88 deficiency attenuates lethal inflammation in sepsis, cell-specific functions of MyD88 remain largely unknown. Using mice with selective expression of MyD88 in myeloid cells (Myd88MYEL), we show that, during polymicrobial septic
Autor:
Heike Weighardt, Simone Kaiser-Moore, Volker Assfalg, Manfred Stangl, Bernhard Holzmann, Daniel Reim, Tanja Rossmann-Bloeck, Alexander Novotny, Norbert Hüser, Klaus Emmanuel
Publikováno v:
Shock. 33:155-161
Effective immunosuppressive therapy is essential to prevent transplant rejection but renders patients vulnerable to opportunistic infections. The present study investigates the effects of common immunosuppressive drugs on the course of septic periton
Autor:
Alexander Novotny, Bernhard Holzmann, Peter F. Mühlradt, Martina Rump, Carolin Feterowski, Tanja Roßmann-Bloeck, Heike Weighardt, Simone Kaiser-Moore
Publikováno v:
International Immunology. 17:1035-1046
The innate immune system uses Toll-like receptors (TLRs) to activate and instruct immune responses against microbial pathogens. Administration of TLR agonists to mice induces a state of hyporesponsiveness, or tolerance, characterized by reduced cytok
Autor:
Bernhard Holzmann, Daniel Reim, Gabriela Jusek, Olivia Prazeres da Costa, Tanja Rossmann-Bloeck
Publikováno v:
Journal of leukocyte biology. 90(3)
The signaling adapters MyD88 and TRIF are engaged by TLRs and/or receptors of the IL-1 family and are considered important for innate immune responses that combat bacterial infections. Here, the consequences of a combined MyD88 and TRIF deficiency fo
Autor:
Bernhard Holzmann, Tanja Rossmann-Bloeck, Sylvia Schlautkötter, Ulrike Schleicher, Christian Bogdan, Heike Weighardt, Simone Kaiser-Moore
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 177(8)
TLRs are considered important for the control of immune responses during endotoxic shock or polymicrobial sepsis. Signaling by TLRs may proceed through the adapter proteins MyD88 or TIR domain-containing adaptor inducinng IFN-β. Both pathways can le