Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Tanja Ouimet"'
Publikováno v:
Headache: The Journal of Head and Face Pain. 63:621-633
Autor:
Amélie Descheemaeker, Hervé Poras, Michel Wurm, Philippe Luccarini, Tanja Ouimet, Radhouane Dallel
Publikováno v:
Brain-A Journal of Neurology
Brain-A Journal of Neurology, Oxford University Press (OUP), 2022, ⟨10.1093/brain/awac139⟩
Brain-A Journal of Neurology, Oxford University Press (OUP), 2022, ⟨10.1093/brain/awac139⟩
The dual enkephalinase inhibitor PL37, a small molecule that protects enkephalins from rapid degradation, has demonstrated analgesic properties in animal pain models and in early human clinical trials. This study tested the antimigraine potential of
Autor:
Cyrine Ben-Dhaou, Hervé Poras, Christophe Baudouin, Stéphane Melik Parsadaniantz, Wurm Michel, Annabelle Réaux-Le Goazigo, Tanja Ouimet
Publikováno v:
PAIN
PAIN, Elsevier, 2019, 160 (2), pp.307-321. ⟨10.1097/j.pain.0000000000001419⟩
PAIN, Elsevier, 2019, 160 (2), pp.307-321. ⟨10.1097/j.pain.0000000000001419⟩
Ocular pain is a core symptom of inflammatory or traumatic disorders affecting the anterior segment. To date, the management of chronic ocular pain remains a therapeutic challenge in ophthalmology. The main endogenous opioids (enkephalins) play a key
Autor:
Simon Leiris, Rémi Patouret, Marie-Claude Fournie-Zaluski, Tanja Ouimet, Hervé Poras, Bernard P. Roques
Publikováno v:
Bioorganic & Medicinal Chemistry Letters
Bioorganic & Medicinal Chemistry Letters, 2017, 27 (16), pp.3883-3890. ⟨10.1016/j.bmcl.2017.06.050⟩
Bioorganic & Medicinal Chemistry Letters, 2017, 27 (16), pp.3883-3890. ⟨10.1016/j.bmcl.2017.06.050⟩
International audience; New neprilysin inhibitors containing an alpha-mercaptoketone HSC((RR2)-R-1)CO group, as zinc ligand were designed. Two parameters were explored for potency optimization: the size of the inhibitor which could interact with the
Autor:
Hervé Poras, Marie-Claude Fournie-Zaluski, Céline Ratinaud-Giraud, Bernard P. Roques, Tanja Ouimet, Sophie Duquesnoy
Publikováno v:
Analytical Biochemistry. 441:152-161
Leukotriene A4 hydrolase (LTA4H) is a bifunctional zinc-dependent metalloprotease bearing both an epoxide hydrolase, producing the pro-inflammatory LTB4 leukotriene, and an aminopeptidase activity, whose physiological relevance has long been ignored.
Publikováno v:
SLAS Discovery. 18:726-735
Detection and quantification of low doses of botulinum toxin serotype A (BoNT/A) in medicinal preparations require precise and sensitive methods. With mounting pressure from governmental authorities to replace the mouse LD50 assay, interest in altern
Autor:
Marie-Claude Fournie-Zaluski, Bernard P. Roques, Hervé Poras, Ana Baamonde, Luis Menéndez, Ana Lastra, Tanja Ouimet, Sara González-Rodríguez
Publikováno v:
Scandinavian Journal of Pain
Scandinavian Journal of Pain, Elsevier, 2017, 14, pp.25-38. ⟨10.1016/j.sjpain.2016.09.011⟩
Scandinavian Journal of Pain, Elsevier, 2017, 14, pp.25-38. ⟨10.1016/j.sjpain.2016.09.011⟩
Background The first line pharmacological treatment of cancer pain is morphine and surrogates but a significant pain relief and a reduction of the side-effects of these compounds makes it necessary to combine them with other drugs acting on different
Autor:
Michèle Vialette, Emilie Dange, Tanja Ouimet, Marie-Claude Fournie-Zaluski, Sophie Duquesnoy, Anthony Pinon, Hervé Poras
Publikováno v:
Journal of Biological Chemistry. 287:20221-20230
Legionella pneumophila has been shown to secrete a protease termed major secretory protein (Msp). This protease belongs to the M4 family of metalloproteases and shares 62.9% sequence similarity with pseudolysin (EC 3.4.24.26). With the aim of develop
Autor:
Sébastien Ballet, J. Garot, Bernard P. Roques, Sophie Duquesnoy, Tanja Ouimet, Fabien Hyafil, François Deux, Eric Lancelot, Marjorie Lemaître, Mario Rienzo, Claire Corot, Jean-Baptiste Michel
Publikováno v:
Molecular Pharmaceutics. 9:850-861
P947 (DOTA-Gd-peptide) was recently identified as an MRI contrast agent for the detection and characterization of the matrix metalloproteinases (MMP)-rich atherosclerotic plaques. Because this product displays a broad spectrum affinity for the MMP fa
Autor:
Sou-Vinh Orng, Emilie Dange, Marie-Claude Fournie-Zaluski, Hervé Poras, Tanja Ouimet, Bernard P. Roques
Publikováno v:
Analytical Biochemistry. 419:95-105
Protease inhibitors represent a major class of drugs, even though a large number of proteases remain unexplored. Consequently, a great interest lies in the identification of highly sensitive substrates useful for both the characterization and the val