Effect of childhood trauma on adult depression and neuroendocrine function: sex-specific moderation by CRH receptor 1 gene

Autor: Christine Heim, Bekh Bradley, Tanja Mletzko, Todd C Deveau, Dominique L Musselmann, Charles B Nemeroff, Kerry J Ressler, Elisabeth B Binder

Publikováno v: Frontiers in Behavioral Neuroscience, Vol 3 (2009)

Variations of the corticotropin-releasing hormone receptor 1 (CRHR1) gene appear to moderate the development of depression after childhood trauma. Depression more frequently affects women than men. We examined sex differences in the effects of the CR

Externí odkaz: https://doaj.org/article/8465f4dfdc3643efaf94833c02b8838c

Single-Dose Psilocybin for a Treatment-Resistant Episode of Major Depression

Autor: Guy M. Goodwin, Scott T. Aaronson, Oscar Alvarez, Peter C. Arden, Annie Baker, James C. Bennett, Catherine Bird, Renske E. Blom, Christine Brennan, Donna Brusch, Lisa Burke, Kete Campbell-Coker, Robin Carhart-Harris, Joseph Cattell, Aster Daniel, Charles DeBattista, Boadie W. Dunlop, Katherine Eisen, David Feifel, MacKenzie Forbes, Hannah M. Haumann, David J. Hellerstein, Astrid I. Hoppe, Muhammad I. Husain, Luke A. Jelen, Jeanine Kamphuis, Julie Kawasaki, John R. Kelly, Richard E. Key, Ronit Kishon, Stephanie Knatz Peck, Gemma Knight, Martijn H.B. Koolen, Melanie Lean, Rasmus W. Licht, Jessica L. Maples-Keller, Jan Mars, Lindsey Marwood, Martin C. McElhiney, Tammy L. Miller, Arvin Mirow, Sunil Mistry, Tanja Mletzko-Crowe, Liam N. Modlin, René E. Nielsen, Elizabeth M. Nielson, Sjoerd R. Offerhaus, Veronica O’Keane, Tomáš Páleníček, David Printz, Marleen C. Rademaker, Aumer van Reemst, Frederick Reinholdt, Dimitris Repantis, James Rucker, Samuel Rudow, Simon Ruffell, A. John Rush, Robert A. Schoevers, Mathieu Seynaeve, Samantha Shao, Jair C. Soares, Metten Somers, Susan C. Stansfield, Diane Sterling, Aaron Strockis, Joyce Tsai, Lucy Visser, Mourad Wahba, Samuel Williams, Allan H. Young, Paula Ywema, Sidney Zisook, Ekaterina Malievskaia

Publikováno v: Goodwin, G M, Aaronson, S T, Alvarez, O, Arden, P C, Baker, A, Bennett, J C, Bird, C, Blom, R E, Brennan, C, Brusch, D, Burke, L, Campbell-Coker, K, Carhart-Harris, R, Cattell, J, Daniel, A, DeBattista, C, Dunlop, B W, Eisen, K, Feifel, D, Forbes, M, Haumann, H M, Hellerstein, D J, Hoppe, A I, Husain, M I, Jelen, L A, Kamphuis, J, Kawasaki, J, Kelly, J R, Key, R E, Kishon, R, Knatz Peck, S, Knight, G, Koolen, M H B, Lean, M, Licht, R W, Maples-Keller, J L, Mars, J, Marwood, L, McElhiney, M C, Miller, T L, Mirow, A, Mistry, S, Mletzko-Crowe, T, Modlin, L N, Nielsen, R E, Nielson, E M, Offerhaus, S R, O’Keane, V, Páleníček, T, Printz, D, Rademaker, M C, van Reemst, A, Reinholdt, F, Repantis, D, Rucker, J, Rudow, S, Ruffell, S, Rush, A J, Schoevers, R A, Seynaeve, M, Shao, S, Soares, J C, Somers, M, Stansfield, S C, Sterling, D, Strockis, A, Tsai, J, Visser, L, Wahba, M, Williams, S, Young, A H, Ywema, P, Zisook, S & Malievskaia, E 2022, ' Single-Dose Psilocybin for a Treatment-Resistant Episode of Major Depression ', New England Journal of Medicine, vol. 387, no. 18, pp. 1637-1648 . https://doi.org/10.1056/NEJMoa2206443
The New England journal of medicine, 387(18), 1637-1648. MASSACHUSETTS MEDICAL SOC
Goodwin, G M, Aaronson, S T, Alvarez, O, Arden, P C, Baker, A, Bennett, J C, Bird, C, Blom, R E, Brennan, C, Brusch, D, Burke, L, Campbell-Coker, K, Carhart-Harris, R, Cattell, J, Daniel, A, DeBattista, C, Dunlop, B W, Eisen, K, Feifel, D, Forbes, M, Haumann, H M, Hellerstein, D J, Hoppe, A I, Husain, M I, Jelen, L A, Kamphuis, J, Kawasaki, J, Kelly, J R, Key, R E, Kishon, R, Knatz Peck, S, Knight, G, Koolen, M H B, Lean, M, Licht, R W, Maples-Keller, J L, Mars, J, Marwood, L, McElhiney, M C, Miller, T L, Mirow, A, Mistry, S, Mletzko-Crowe, T, Modlin, L N, Nielsen, R E, Nielson, E M, Offerhaus, S R, O'Keane, V, Páleníček, T, Printz, D, Rademaker, M C, van Reemst, A, Reinholdt, F, Repantis, D, Rucker, J, Rudow, S, Ruffell, S, Rush, A J, Schoevers, R A, Seynaeve, M, Shao, S, Soares, J C, Somers, M, Stansfield, S C, Sterling, D, Strockis, A, Tsai, J, Visser, L, Wahba, M, Williams, S, Young, A H, Ywema, P, Zisook, S & Malievskaia, E 2022, ' Single-Dose Psilocybin for a Treatment-Resistant Episode of Major Depression. ', The New England Journal of Medicine, vol. 387, no. 18, pp. 1637-1648 . https://doi.org/10.1056/NEJMoa2206443

BACKGROUND: Psilocybin is being studied for use in treatment-resistant depression.METHODS: In this phase 2 double-blind trial, we randomly assigned adults with treatment-resistant depression to receive a single dose of a proprietary, synthetic formul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30b8742fc702d2c23f77f5222cb3a4d0
https://doi.org/10.1056/nejmoa2206443

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Effects of Patient Preferences on Outcomes in the Predictors of Remission in Depression to Individual and Combined Treatments (PReDICT) Study

Autor: Boadie W. Dunlop, Becky Kinkead, Tanja Mletzko-Crowe, Vivianne Aponte-Rivera, W. Edward Craighead, Helen S. Mayberg, Charles B. Nemeroff, Mary E. Kelley, James C. Ritchie

Publikováno v: American Journal of Psychiatry. 174:546-556

The Predictors of Remission in Depression to Individual and Combined Treatments [PReDICT] study aimed to identify clinical and biological factors predictive of treatment outcomes in major depressive disorder among treatment-naive adults. The authors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ba88eb7547fffdd6c8b1031f237e468
https://doi.org/10.1176/appi.ajp.2016.16050517

Time-dependent effects of dexamethasone plasma concentrations on glucocorticoid receptor challenge tests

Autor: Tanja Mletzko Crowe, Tamara Gerlach, Andreas Menke, Susanne Lucae, Steven J. Garlow, Elisabeth B. Binder, Darina Czamara, Janine Arloth, Charles B. Nemeroff, Johanna Best, Helen S. Mayberg, Christian Namendorf, Monika Rex-Haffner, Manfred Uhr, W. Edward Craighead, James C. Ritchie, Boadie W. Dunlop

Publikováno v: Psychoneuroendocrinology. 69:161-171

Glucocorticoid challenge tests such as the dexamethasone suppression test (DST) and the combined dexamethasone/corticotropin-releasing hormone (dex-CRH) test are considered to be able to sensitively measure hypothalamic-pituitary-adrenal (HPA) axis a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40ec8dc19c3d78bf562805e5151e63dc
https://doi.org/10.1016/j.psyneuen.2016.04.003