Výsledky vyhledávání - "Tanja Matkovic"

Akademický článek

An antagonism between Spinophilin and Syd-1 operates upstream of memory-promoting presynaptic long-term plasticity

Autor: Niraja Ramesh, Marc Escher, Oriane Turrel, Janine Lützkendorf, Tanja Matkovic, Fan Liu, Stephan J Sigrist

Publikováno v: eLife, Vol 12 (2023)

We still face fundamental gaps in understanding how molecular plastic changes of synapses intersect with circuit operation to define behavioral states. Here, we show that an antagonism between two conserved regulatory proteins, Spinophilin (Spn) and

Externí odkaz: https://doaj.org/article/4a356fa83da94f90a638c4488370f580

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Akademický článek

Postsynaptic plasticity of cholinergic synapses underlies the induction and expression of appetitive and familiarity memories in Drosophila

Autor: Carlotta Pribbenow, Yi-chun Chen, M-Marcel Heim, Desiree Laber, Silas Reubold, Eric Reynolds, Isabella Balles, Tania Fernández-d V Alquicira, Raquel Suárez-Grimalt, Lisa Scheunemann, Carolin Rauch, Tanja Matkovic, Jörg Rösner, Gregor Lichtner, Sridhar R Jagannathan, David Owald

Publikováno v: eLife, Vol 11 (2022)

In vertebrates, several forms of memory-relevant synaptic plasticity involve postsynaptic rearrangements of glutamate receptors. In contrast, previous work indicates that Drosophila and other invertebrates store memories using presynaptic plasticity

Externí odkaz: https://doaj.org/article/560863adef014a4d8e8368bd5c9f3ca7

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Akademický článek

Unc13A and Unc13B contribute to the decoding of distinct sensory information in Drosophila

Autor: Atefeh Pooryasin, Marta Maglione, Marco Schubert, Tanja Matkovic-Rachid, Sayed-mohammad Hasheminasab, Ulrike Pech, André Fiala, Thorsten Mielke, Stephan J. Sigrist

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

The physical distance between synaptic Ca2+ channels and sensors modulates short-term plasticity (STP). Here, the authors show that synaptic release factors Unc13A and Unc13B distinctly couple with Ca2+ channels and contribute to the neural decoding

Externí odkaz: https://doaj.org/article/1555961b6bb840d7b6165c99930a8b08

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Akademický článek

Translational control of polyamine metabolism by CNBP is required for Drosophila locomotor function

Autor: Sonia Coni, Federica A Falconio, Marta Marzullo, Marzia Munafò, Benedetta Zuliani, Federica Mosti, Alessandro Fatica, Zaira Ianniello, Rosa Bordone, Alberto Macone, Enzo Agostinelli, Alessia Perna, Tanja Matkovic, Stephan Sigrist, Gabriella Silvestri, Gianluca Canettieri, Laura Ciapponi

Publikováno v: eLife, Vol 10 (2021)

Microsatellite expansions of CCTG repeats in the cellular nucleic acid-binding protein (CNBP) gene leads to accumulation of toxic RNA and have been associated with myotonic dystrophy type 2 (DM2). However, it is still unclear whether the dystrophic p

Externí odkaz: https://doaj.org/article/e2297eac8cb54bc882d8e8ccac2b6c5b

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Akademický článek

Active Zone Scaffold Protein Ratios Tune Functional Diversity across Brain Synapses

Autor: Andreas Fulterer, Till F.M. Andlauer, Anatoli Ender, Marta Maglione, Katherine Eyring, Jennifer Woitkuhn, Martin Lehmann, Tanja Matkovic-Rachid, Joerg R.P. Geiger, Alexander M. Walter, Katherine I. Nagel, Stephan J. Sigrist

Publikováno v: Cell Reports, Vol 23, Iss 5, Pp 1259-1274 (2018)

Summary: High-throughput electron microscopy has started to reveal synaptic connectivity maps of single circuits and whole brain regions, for example, in the Drosophila olfactory system. However, efficacy, timing, and frequency tuning of synaptic ves

Externí odkaz: https://doaj.org/article/f860d780eed74f568c5c7db9c0f022f6

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Akademický článek

A high affinity RIM-binding protein/Aplip1 interaction prevents the formation of ectopic axonal active zones

Publikováno v: eLife, Vol 4 (2015)

Synaptic vesicles (SVs) fuse at active zones (AZs) covered by a protein scaffold, at Drosophila synapses comprised of ELKS family member Bruchpilot (BRP) and RIM-binding protein (RBP). We here demonstrate axonal co-transport of BRP and RBP using intr

Externí odkaz: https://doaj.org/article/cc5f709ea3a149bb840b71b1ba400d10

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Interactive nanocluster compaction of the ELKS scaffold and Cacophony Ca2+ channels drives sustained active zone potentiation

Autor: Tina Ghelani, Marc Escher, Ulrich Thomas, Klara Esch, Janine Lützkendorf, Harald Depner, Marta Maglione, Pierre Parutto, Scott Gratz, Tanja Matkovic-Rachid, Stefanie Ryglewski, Alexander M. Walter, David Holcman, Kate O‘Connor Giles, Martin Heine, Stephan J. Sigrist

Publikováno v: Ghelani, T, Escher, M, Thomas, U, Esch, K, Lützkendorf, J, Depner, H, Maglione, M, Parutto, P, Gratz, S, Matkovic-Rachid, T, Ryglewski, S, Walter, A M, Holcman, D, O'Connor Giles, K, Heine, M & Sigrist, S J 2023, ' Interactive nanocluster compaction of the ELKS scaffold and Cacophony Ca 2+ channels drives sustained active zone potentiation ', Science Advances, vol. 9, no. 7, eade7804 . https://doi.org/10.1126/sciadv.ade7804

At presynaptic active zones (AZs), conserved scaffold protein architectures control synaptic vesicle (SV) release by defining the nanoscale distribution and density of voltage-gated Ca2+ channels (VGCCs). While AZs can potentiate SV release in the mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79847645598ba22cc261d90d97030338
https://repository.publisso.de/resource/frl:6440400

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