Výsledky vyhledávání - "Tanja Kirchberger"

Ligand-induced activation of human TRPM2 requires the terminal ribose of ADPR and involves Arg1433 and Tyr1349

Autor: Wiebke Sick, Angelika Harneit, Andrea C. Araujo, Ralf Fliegert, Monika D. Rozewitz, Anja Schöbel, Tanja Kirchberger, Joanna M. Watt, Mark P. Thomas, Andreas H. Guse, Barry V. L. Potter, Christelle Moreau

Publikováno v: Biochemical Journal

TRPM2 (transient receptor potential channel, subfamily melastatin, member 2) is a Ca2+-permeable non-selective cation channel activated by the binding of adenosine 5′-diphosphoribose (ADPR) to its cytoplasmic NUDT9H domain (NUDT9 homology domain).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e149b107746fd09de4ed57b19cf45fbb
https://doi.org/10.1042/bcj20170091

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2′-Deoxyadenosine 5′-diphosphoribose is an endogenous TRPM2 superagonist

Autor: Christelle Moreau, Angelika Harneit, Adriana-Michelle Wolf Pérez, Marianne Flato, Annette Rosche, Feng Gu, Joanna M. Watt, Ralf Fliegert, Tanja Kirchberger, Andreas H. Guse, Mareike Janus, Riekje Winzer, Monika D. Rozewitz, Valerie Wolters, Andreas Bauche, Barry V. L. Potter

Publikováno v: Fliegert, R, Bauche, A, Wolf Pérez, A-M, Watt, J M, Rozewitz, M D, Winzer, R, Janus, M, Gu, F, Rosche, A, Harneit, A, Flato, M, Moreau, C, Kirchberger, T, Wolters, V, Potter, B V L & Guse, A H 2017, ' 2ʹ-Deoxyadenosine 5ʹ-diphosphoribose is an endogenous TRPM2 superagonist ', Nature Chemical Biology, vol. 13, pp. 1036-1044 . https://doi.org/10.1038/nchembio.2415

Transient receptor potential melastatin 2 (TRPM2) is a ligand-gated Ca2+-permeable nonselective cation channel. Whereas physiological stimuli, such as chemotactic agents, evoke controlled Ca2+ signals via TRPM2, pathophysiological stimuli such as rea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98326694e9d3f2fec0bd754b24256d0c
https://europepmc.org/articles/PMC5563452/

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Aberrant Cyclization Affords a C-6 Modified Cyclic Adenosine 5′-Diphosphoribose Analogue with Biological Activity in Jurkat T Cells

Autor: Christelle Moreau, Mark P. Thomas, Bo Zhang, Barry V. L. Potter, Tanja Kirchberger, Karin Weber, Andreas H. Guse

Publikováno v: Journal of Medicinal Chemistry

Two nicotinamide adenine dinucleotide (NAD(+)) analogues modified at the 6 position of the purine ring were synthesized, and their substrate properties toward Aplysia californica ADP-ribosyl cyclase were investigated. 6-N-Methyl NAD(+) (6-N-methyl ni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::886eccd0cb2d43a1ba4cebbbf1832fee
https://doi.org/10.1021/jm201127y

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8-Bromo-cyclic inosine diphosphoribose: towards a selective cyclic ADP-ribose agonist

Autor: Alexander Flügel, Angelika Harneit, Barry V. L. Potter, Francesca Odoardi, Cornelia C. Siebrands, Christelle Moreau, Gerd K. Wagner, Merle Nebel, Ralf Fliegert, Tanja Kirchberger, Frederike Schmid, Andreas H. Guse

Publikováno v: Biochemical Journal

cADPR (cyclic ADP-ribose) is a universal Ca(2+) mobilizing second messenger. In T-cells cADPR is involved in sustained Ca(2+) release and also in Ca(2+) entry. Potential mechanisms for the latter include either capacitative Ca(2+) entry, secondary to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de003221a653a6ee7112701955e24f8d
https://doi.org/10.1042/bj20082308

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NAADP Mobilizes Calcium from the Endoplasmic Reticular Ca2+ Store in T-lymphocytes

Autor: Tanja Kirchberger, Mareike Steen, Andreas H. Guse

Publikováno v: Journal of Biological Chemistry. 282:18864-18871

The target calcium store of nicotinic acid adenine dinucleotide phosphate (NAADP), the most potent endogenous calcium-mobilizing compound known to date, has been proposed to reside in the lysosomal compartment or in the endo/sarcoplasmic reticulum. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f35ef605fdae587cd57c4c3257abf798
https://doi.org/10.1074/jbc.m610925200

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Cellular effects and metabolic stability ofN1-cyclic inosine diphosphoribose and its derivatives

Autor: Andreas Gasser, Lee Zhang, Gerd K. Wagner, Barry V. L. Potter, Sören Bruhn, P. Wang, Tanja Kirchberger, Ralf Fliegert, Chiara Cordiglieri, Andreas H. Guse, Andreas Flügel, Fren Lund, Jianfeng Xu

Publikováno v: British Journal of Pharmacology. 149:337-344

Background and purpose:Recently, a number of mimics of the second messenger cyclic ADP-ribose (cADPR) with replacement of adenosine by inosine were introduced. In addition, various alterations in t ...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ef4d0ae6d8187ecd27ec79851f2aba2e
https://doi.org/10.1038/sj.bjp.0706869

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Measuring CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) activity by reverse-phase HPLC

Autor: Andreas H. Guse, Tanja Kirchberger

Publikováno v: Cold Spring Harbor protocols. 2013(6)

Cyclic ADP-ribose (cADPR) is a Ca2+-mobilizing second messenger active in many cell types, tissues, and organisms. The mammalian NAD-glycohydrolase CD38 catalyzes formation of cADPR by removing nicotinamide and forming a new intramolecular bond betwe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::280522805355ccbb53c219d3a63839f9
https://pubmed.ncbi.nlm.nih.gov/23734017

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Trifluoromethylated cyclic-ADP-ribose mimic: synthesis of 8-trifluoromethyl-N(1)-[(5'-O-phosphorylethoxy)methyl]-5'-O-phosphorylinosine-5',5'-cyclic pyrophosphate (8-CF(3)-cIDPRE) and its calcium release activity in T cells

Autor: Andreas H. Guse, Tanja Kirchberger, Zhenjun Yang, Min Dong, Xiangchen Huang, Liangren Zhang, Lihe Zhang

Publikováno v: Organicbiomolecular chemistry. 8(20)

A convenient trifluoromethylation method was firstly applied to the synthesis of 8- CF(3)-purine nucleosides. On the basis of this method, new protection and deprotection strategies were developed for the successful synthesis of the trifluoromethylat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa21f166fd494c1e598a1ad39c0f9885
https://pubmed.ncbi.nlm.nih.gov/20740240

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