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Autor:
Lena Cook, Tiziano Tuccinardi, Caterina Camodeca, Armando Rossello, Tanja Kellermann, Elisa Nuti, Doretta Cuffaro, Lidia Ciccone, Jörg W. Bartsch
Publikováno v:
ACS Medicinal Chemistry Letters
The metalloproteinase ADAM8 is upregulated in several cancers but has a dispensable function under physiological conditions. In tumor cells, ADAM8 is involved in invasion, migration, and angiogenesis. The use of bivalent inhibitors could impair migra