Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Tanja K. Froehlich"'
Autor:
Huixing Huang, Dominic Schaerer, Remington Schmidt, Ting Zhang, Tanja K Froehlich, Kelly Bouchonville, Robert B Diasio, Ursula Amstutz, Carlo Largiadèr, Steven M Offer
Publikováno v:
Cancer Research. 82:5805-5805
The primary mechanism of action for the chemotherapeutic 5-fluorouracil (5-FU) is inhibition of thymidylate synthase (TS), which leads to nucleotide imbalance and subsequent cellular death. Expression of TS has been suggested to be determined by a va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::807e8e12c06485ae9394e7743955af4f
https://doi.org/10.1158/1538-7445.am2022-5805
https://doi.org/10.1158/1538-7445.am2022-5805
Autor:
Olivier Engler, Lauro Damonti, Pascal Bittel, Alexander Eggel, Christoph Hauser, Benjamin Weber, Carlo R. Largiadèr, Denise Siegrist, Stephen L. Leib, Peter S. Kim, Michael Nagler, Tanja K. Froehlich, Hanspeter Stalder, Daniel Brigger, Theodore S. Jardetzky, Michael P. Horn, Peter M. Villiger, Jonas Marschall, Luke F. Pennington, Vanja Piezzi, Abigail E. Powell, Martin Fiedler, Martin F. Bachmann, Patricia Iseli
Publikováno v:
Allergy
Brigger, D.; Horn, M. P.; Pennington, L. F.; Powell, A. E.; Siegrist, D.; Weber, B.; Engler, O.; Piezzi, V.; Damonti, L.; Iseli, P.; Hauser, C.; Froehlich, T. K.; Villiger, P. M.; Bachmann, Martin F.; Leib, S. L.; Bittel, P.; Fiedler, M.; Largiadèr, C.; Marschall, J.; Stalder, H.; ... (2021). Accuracy of serological testing for SARS-CoV-2 antibodies: first results of a large mixed-method evaluation study. Allergy, 76(3), pp. 853-865. Wiley 10.1111/all.14608
Brigger, D.; Horn, M. P.; Pennington, L. F.; Powell, A. E.; Siegrist, D.; Weber, B.; Engler, O.; Piezzi, V.; Damonti, L.; Iseli, P.; Hauser, C.; Froehlich, T. K.; Villiger, P. M.; Bachmann, Martin F.; Leib, S. L.; Bittel, P.; Fiedler, M.; Largiadèr, C.; Marschall, J.; Stalder, H.; ... (2021). Accuracy of serological testing for SARS-CoV-2 antibodies: first results of a large mixed-method evaluation study. Allergy, 76(3), pp. 853-865. Wiley 10.1111/all.14608
BACKGROUND Serological immunoassays that can identify protective immunity against SARS-CoV-2 are needed to adapt quarantine measures, assess vaccination responses, and evaluate donor plasma. To date, however, the utility of such immunoassays remains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc6ef6bc3d775fb320c96f89d9aee7f2
Autor:
Daniel Brigger, Michael P. Horn, Luke F. Pennington, Abigail E. Powell, Vanja Piezzi, Lauro Damonti, Patricia Iseli, Christoph Hauser, Tanja K. Froehlich, Martin F. Bachmann, Stephen L. Leib, Pascal Bittel, Martin Fiedler, Carlo Largiadèr, Jonas Marschall, Hanspeter Stalder, Peter S. Kim, Theodore S. Jardetzky, Alexander Eggel, Michael Nagler
Publikováno v:
SSRN Electronic Journal.
Background: Significant hope and expectation has been placed on serological immunoassays to test for previous COVID-19 infection, to determine immunity against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc81ed5d0a748d891f7106fd9740938f
https://doi.org/10.2139/ssrn.3605126
https://doi.org/10.2139/ssrn.3605126
Autor:
Daniel Brigger, Michael P. Horn, Luke F. Pennington, Abigail E. Powell, Denise Siegrist, Benjamin Weber, Olivier Engler, Vanja Piezzi, Lauro Damonti, Patricia Iseli, Christoph Hauser, Tanja K. Froehlich, Peter M. Villiger, Martin F. Bachmann, Stephen L. Leib, Pascal Bittel, Martin Fiedler, Carlo Largiadèr, Jonas Marschall, Hanspeter Stalder, Peter S. Kim, Theodore S. Jardetzky, Alexander Eggel, Michael Nagler
Publikováno v:
SSRN Electronic Journal.
Background: Serological immunoassays that are able to identify protective immunity against SARS-CoV-2 are urgently required to adapt quarantine measures, assess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::656ecdd9e73d63c75a9733a7452d9061
https://doi.org/10.2139/ssrn.3606446
https://doi.org/10.2139/ssrn.3606446
Autor:
N Wenger, Carlo R. Largiadèr, Tanja K. Froehlich, Stefan Aebi, Ursula Amstutz, Markus Joerger, Seid Hamzic
Publikováno v:
The Pharmacogenomics Journal. 17:319-324
A missense variant (c.1637C>T, T546M) in ABCC11 encoding the MRP8 (multidrug resistance protein 8), a transporter of 5-fluorodeoxyuridine monophosphate, has been associated with an increased risk of 5-fluorouracil-related severe leukopenia. To valida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca0eac5f2098929e05e04c2be9be995
https://doi.org/10.1038/tpj.2016.23
https://doi.org/10.1038/tpj.2016.23
Autor:
Jan H.M. Schellens, Ursula Amstutz, Didier Meulendijks, Anthonius de Boer, Linda M. Henricks, Maarten J. Deenen, Jos H. Beijnen, Annemieke Cats, Tanja K. Froehlich, Carlo R. Largiadèr
Publikováno v:
International Journal of Cancer. 138:2752-2761
The objective of this study was to determine whether genotyping of MIR27A polymorphisms rs895819A>G and rs11671784C>T can be used to improve the predictive value of DPYD variants to identify patients at risk of severe fluoropyrimidine-associated toxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e297156756c82c21a8463cae10d57e59
https://doi.org/10.1002/ijc.30014
https://doi.org/10.1002/ijc.30014
Autor:
Markus Joerger, Tanja K. Froehlich, Jan H.M. Schellens, Didier Meulendijks, Seid Hamzic, Carlo R. Largiadèr, Claire Palles, Xandra García-González, Luis A. López-Fernández, Ursula Amstutz, Stefan Aebi, Ian Thomlinson, Dominic Kummer
Publikováno v:
Hamzic, Seid; Kummer, Dominic; Froehlich, Tanja K.; Joerger, Markus; Aebi, Stefan; Palles, Claire; Thomlinson, Ian; Meulendijks, Didier; Schellens, Jan H M; García-González, Xandra; López-Fernández, Luis A; Amstutz, Ursula; Largiadèr, Carlo R. (2020). Evaluating the role of ENOSF1 and TYMS variants as predictors in fluoropyrimidine-related toxicities: An IPD meta-analysis. Pharmacological research, 152, p. 104594. Elsevier 10.1016/j.phrs.2019.104594
To assess the proposed associations of the c.742-227G>A (rs2612091) polymorphism within the Enolase Superfamily Member 1 gene (ENOSF1) and two variants in the adjacent Thymidylate Synthase gene (TYMS): the 5'VNTR 28bp-repeat (rs45445694) and 3'UTR 6b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0538ca7b50626329d7ea32ce5b5f3e8
https://doi.org/10.1016/j.phrs.2019.104594
https://doi.org/10.1016/j.phrs.2019.104594
Publikováno v:
INTERNATIONAL JOURNAL OF CANCER
We investigated the clinical relevance of dihydropyrimidine dehydrogenase gene (DPYD) variants to predict severe early onset fluoropyrimidine (FP) toxicity in particular of a recently discovered haplotype hapB3 and a linked deep intronic splice site
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f0e5f916ef06ac6244a959550ae50b42
Autor:
Tanja K. Froehlich, Ursula Amstutz, Stefan Aebi, Johanna Sistonen, Dominic Kummer, Markus Joerger, Carlo R. Largiadèr
Publikováno v:
PHARMACOGENOMICS
Aims: To assess the association of DPYS and UPB1 genetic variation, encoding the catabolic enzymes downstream of dihydropyrimidine dehydrogenase, with early-onset toxicity from fluoropyrimidine-based chemotherapy. Patients & methods: The coding and e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::835985a095236875cf90851ac29655f4
Publikováno v:
Pharmacogenomics
The importance of polymorphisms in the dihydropyrimidine dehydrogenase (DPD) gene (DPYD) for the prediction of severe toxicity in 5-fluorouracil (5-FU) based chemotherapy has been controversially debated. As a key enzyme in the catabolism of 5-FU, DP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c7457292632b773c6b99e9260cf7cb1