Longitudinal CSF proteome profiling in mice to uncover the acute and sustained mechanisms of action of rapid acting antidepressant (2R,6R)-hydroxynorketamine (HNK)

Autor: David P. Herzog, Natarajan Perumal, Caroline Manicam, Giulia Treccani, Jens Nadig, Milena Rossmanith, Jan Engelmann, Tanja Jene, Annika Hasch, Michael A. van der Kooij, Klaus Lieb, Nils C. Gassen, Franz H. Grus, Marianne B. Müller

Publikováno v: Neurobiology of Stress, Vol 15, Iss , Pp 100404- (2021)

Delayed onset of antidepressant action is a shortcoming in depression treatment. Ketamine and its metabolite (2R,6R)-hydroxynorketamine (HNK) have emerged as promising rapid-acting antidepressants. However, their mechanism of action remains unknown.

Externí odkaz: https://doaj.org/article/d8aba74592bc42718b2bc6bf8e42ffef

Longitudinal CSF proteome profiling in mice to uncover the acute and sustained mechanisms of action of rapid acting antidepressant (2R,6R)-hydroxynorketamine (HNK)

Autor: Milena Rossmanith, Jan Engelmann, Nils C. Gassen, Marianne B. Müller, Natarajan Perumal, Michael A. van der Kooij, Giulia Treccani, Annika Hasch, Caroline Manicam, David P. Herzog, Klaus Lieb, Tanja Jene, Jens Nadig, Franz H. Grus

Publikováno v: Neurobiology of Stress, Vol 15, Iss, Pp 100404-(2021)
Neurobiology of Stress, 15:100404
Neurobiology of Stress
Herzog, D P, Perumal, N, Manicam, C, Treccani, G, Nadig, J, Rossmanith, M, Engelmann, J, Jene, T, Hasch, A, van der Kooij, M A, Lieb, K, Gassen, N C, Grus, F H & Müller, M B 2021, ' Longitudinal CSF proteome profiling in mice to uncover the acute and sustained mechanisms of action of rapid acting antidepressant (2R,6R)-hydroxynorketamine (HNK) ', Neurobiology of Stress, vol. 15, 100404 . https://doi.org/10.1016/j.ynstr.2021.100404

Delayed onset of antidepressant action is a shortcoming in depression treatment. Ketamine and its metabolite (2R,6R)-hydroxynorketamine (HNK) have emerged as promising rapid-acting antidepressants. However, their mechanism of action remains unknown.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92f8a2dcd3a31a45ff0d900d72b542e6
http://www.sciencedirect.com/science/article/pii/S2352289521001120

Chronic social stress-induced hyperglycemia in mice couples individual stress susceptibility to impaired spatial memory

Autor: Stefan Walenta, Michael A. van der Kooij, Marianne B. Müller, Tanja Jene, Isabelle Miederer, Nadine Voelxen, Annika Hasch, Giulia Treccani

Publikováno v: van der Kooij, M A, Jene, T, Treccani, G, Miederer, I, Hasch, A, Voelxen, N, Walenta, S & Müller, M B 2018, ' Chronic social stress-induced hyperglycemia in mice couples individual stress susceptibility to impaired spatial memory ', Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 43, pp. E10187-E10196 . https://doi.org/10.1073/pnas.1804412115
Proceedings of the National Academy of Sciences of the United States of America, 115(43):E10187-E10196
Proceedings of the National Academy of Sciences of the United States of America

Significance Stress-associated mental disorders and diabetes pose an enormous socio-economic burden. Glucose dysregulation occurs with both psychosocial and metabolic stress. While cognitive impairments are common in metabolic disorders such as diabe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0caeddfa93065e30d0fc63a348d0745c
https://pure.au.dk/portal/da/publications/chronic-social-stressinduced-hyperglycemia-in-mice-couples-individual-stress-susceptibility-to-impaired-spatial-memory(431b8405-e70e-4a0b-a71f-369aaadd280d).html

Temporal profiling of an acute stress-induced behavioral phenotype in mice and role of hippocampal DRR1

Autor: Marianne B. Müller, Verena Opitz, Tanja Jene, Michael A. van der Kooij, Nils C. Gassen, Kristina Endres

Publikováno v: Psychoneuroendocrinology. 91

Understanding the neurobiological mechanisms underlying the response to an acute stressor may provide novel insights into successful stress-coping strategies. Acute behavioral stress-effects may be restricted to a specific time window early after str

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7142c5a72dc57edf4c7ad4ff01b046e6
https://pubmed.ncbi.nlm.nih.gov/29555365

F107. The Molecular Pathways in the Dentate Gyrus and Blood Underlying Poor and Good Antidepressant Treatment Response

Autor: David B. Herzog, Marianne B. Müller, Hyobin Jeong, Diego Pascual Cuadrado, Amitava Basu, Tanja Jene, Verena Opitz, Vijay K. Tiwari, Michael A. van der Kooij

Publikováno v: Biological Psychiatry. 83:S279

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a9dd3e954152db4c006dfc8ca68e1c00
https://doi.org/10.1016/j.biopsych.2018.02.720