Dose Linearity and Proportionality

Autor: Paul Hutson, Ronald Burnette, Tanja Eisenblaetter, Lenore Teichert

Publikováno v: Drug Discovery and Evaluation: Methods in Clinical Pharmacology ISBN: 9783319566375
Drug Discovery and Evaluation: Methods in Clinical Pharmacology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::740d46f08e30446b598edab27f6a0a3d
https://doi.org/10.1007/978-3-319-56637-5_5-1

Plasma Exposure to Insulin Glargine and Its Metabolites M1 and M2 After Subcutaneous Injection of Therapeutic and Supratherapeutic Doses of Glargine in Subjects With Type 1 Diabetes

Autor: Geremia B. Bolli, Raphael Dahmen, Annke D. Hahn, Ronald Schmidt, Reinhard H.A. Becker, Tanja Eisenblaetter, Tim Heise

Publikováno v: Diabetes Care

OBJECTIVE In vivo, after subcutaneous injection, insulin glargine (21A-Gly-31B-Arg-32B-Arg-human insulin) is enzymatically processed into 21A-Gly-human insulin (metabolite 1 [M1]). 21A-Gly-des-30B-Thr-human insulin (metabolite 2 [M2]) is also found.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db21be74b51ffb1665e9109c27998dfb
http://europepmc.org/articles/PMC3507590

Dose Linearity and Proportionality

Autor: Tanja Eisenblaetter, Lenore Teichert

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b2fced6f6aeb100f5bc61641b9d13385
https://doi.org/10.1007/978-3-540-89891-7_5

Distribution – Across Barriers

Autor: Tanja Eisenblaetter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::832b1f54e916288e1b42d0e3ec7feb29
https://doi.org/10.1007/3-540-29804-5_26