Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Tanja Dolinsek"'
Autor:
Spela Kos, Tanja Blagus, Maja Cemazar, Ursa Lampreht Tratar, Monika Stimac, Lara Prosen, Tanja Dolinsek, Urska Kamensek, Simona Kranjc, Lars Steinstraesser, Gaëlle Vandermeulen, Véronique Préat, Gregor Sersa
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
Skin is an attractive target for gene electrotransfer. It consists of different cell types that can be transfected, leading to various responses to gene electrotransfer. We demonstrate that these responses could be controlled by selecting the appropr
Externí odkaz:
https://doaj.org/article/02b918f38a1b42aabd9d9f3e19e00d2b
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0124913 (2015)
Vascular targeted therapies, targeting specific endothelial cell markers, are promising approaches for the treatment of cancer. One of the targets is endoglin, transforming growth factor-β (TGF-β) co-receptor, which mediates proliferation, differen
Externí odkaz:
https://doaj.org/article/1cb5eea24a694af49328512107c6fc38
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 3, Iss C (2014)
The melanoma cell adhesion molecule (MCAM) is involved in melanoma development and its progression, including invasiveness, metastatic potential and angiogenesis. Therefore, MCAM represents a potential target for gene therapy of melanoma, whose expre
Externí odkaz:
https://doaj.org/article/34319bcd341546e2938745cd477b2e2a
Autor:
Tanja Dolinsek, Bostjan Markelc, Gregor Sersa, Andrej Coer, Monika Stimac, Jaka Lavrencak, Andreja Brozic, Simona Kranjc, Maja Cemazar
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58723 (2013)
Endoglin is a transforming growth factor-β (TGF- β) co-receptor that participates in the activation of a signaling pathway that mediates endothelial cell proliferation and migration in angiogenic tumor vasculature. Therefore, silencing of endoglin
Externí odkaz:
https://doaj.org/article/6ebef313650242a497c6a44f0f2df89d
Publikováno v:
Radiology and Oncology, Vol 50, Iss 3, Pp 274-279 (2016)
Radiology and oncology (Ljubljana)
Radiology and Oncology
Radiology and oncology (Ljubljana)
Radiology and Oncology
BackgroundThe aim of the study was to explore the effectiveness of electrochemotherapy (ECT) during the treatment of melanoma patients with BRAF inhibitors. Its effectiveness was tested on BRAF mutated and non-mutated melanoma cellsin vitroand in com
Autor:
Maja Cemazar, Bostjan Markelc, Tanja Dolinsek, Veronika Prevodnik Kloboves, Gregor Sersa, Eva Skvarca, Andrej Coer
Publikováno v:
Bioelectrochemistry. 103:111-119
Application of electric pulses (electroporation/electropermeabilization) is an effective method for gene transfer (i.e. gene electrotransfer (GET)) in vitro and in vivo. Currently, the mechanisms by which the DNA enters the cell are not yet fully und
Autor:
U. Kamensek, Gregor Sersa, M. Bosnjak, Céline Bouquet, Bostjan Markelc, Tanja Dolinsek, Janja Završnik, Maja Cemazar, Tanja Blagus, Simona Kranjc, Monika Stimac, Boris Turk, Loree C. Heller
Publikováno v:
Gene Therapy. 22:578-590
Gene therapy with Plasmid AMEP (antiangiogenic metargidin peptide) has recently been studied as a potential targeted therapy for melanoma. This plasmid is designed to downregulate α5β1 and αvβ3 integrins. In our study, electroporation was used as
Autor:
Simona Kranjc, Maja Cemazar, Lara Prosen, Monika Stimac, Bostjan Markelc, Gregor Sersa, Tanja Blagus, Tanja Dolinsek, Ursa Lampreht, Masa Bosnjak
Publikováno v:
Current Gene Therapy. 15:228-244
New targets and therapeutic approaches for vascular targeted strategies in oncology are continuously explored. Endoglin, a co-receptor of TGF-β, is a known target, however, its silencing with vector-based RNA interference technology has not been eva
Autor:
Gregor Sersa, Maja Cemazar, Tanja Dolinsek, Veronika Prevodnik Kloboves, Primoz Strojan, Tina Kosjek, Bostjan Markelc
Publikováno v:
Strahlentherapie und Onkologie. 190:661-666
Prolonged vinblastine (VLB) infusion and irradiation (IR) lead to favourable results in certain tumours types; however the underlying biological mechanisms of interaction are not well known. The aim of our study was to evaluate the dose- and time-dep