Zobrazeno 1 - 10 of 19 pro vyhledávání: '"Tanja Bus"'
1
3rd generation poly(ethylene imine)s for gene delivery
Autor: Anja Traeger, Matthias Hartlieb, Philipp S. Borchers, Tanja Bus, Christoph Englert, Antje Vollrath, Martin Reifarth, Stephanie Hoeppener, Ulrich S. Schubert
Publikováno v: Journal of materials chemistry. B. 5(6)
Cationic polymers play a crucial role within the field of gene delivery offering the possibility to circumvent (biological) barriers in an elegant way. However, polymers are accompanied either by a high cytotoxicity or low efficiency. In this study,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faadcf9850eab9ecda5732377cefe6bd
https://pubmed.ncbi.nlm.nih.gov/32263594
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2
The Power of Shielding: Low Toxicity and High Transfection Performance of Cationic Graft Copolymers Containing Poly(2-oxazoline) Side Chains
Autor: Martin Sahn, Anja Traeger, Anne-Kristin Trützschler, Ulrich S. Schubert, Christine Weber, Tanja Bus
Publikováno v: Biomacromolecules. 19:2759-2771
We show the potential of oligo(2-ethyl-2-oxazoline) (Oxn)-shielded graft copolymers of (2-aminoethyl)-methacrylate and N-methyl-(2-aminoethyl)-methacrylate for pDNA delivery in HEK cells. For the effect of grafting density and side chain length conce
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb50f2c8a64379eaff9ba199403838c5
https://doi.org/10.1021/acs.biomac.8b00362
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3
The great escape: how cationic polyplexes overcome the endosomal barrier
Autor: Anja Traeger, Ulrich S. Schubert, Tanja Bus
Publikováno v: Journal of Materials Chemistry B. 6:6904-6918
The targeted and efficiency-oriented delivery of (therapeutic) nucleic acids raises hope for successful gene therapy, i.e., for the local and individual treatment of acquired and inherited genetic disorders. Despite promising achievements in the fiel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eae3d0c9981a36e8249bfca8066686cf
https://doi.org/10.1039/c8tb00967h
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4
Tailoring Cellular Uptake and Fluorescence of Poly(2-oxazoline)-Based Nanogels
Autor: Tanja Bus, Meike N. Leiske, Stephanie Hoeppener, Matthias Hartlieb, Joachim Kübel, Kristian Kempe, Benjamin Dietzek, Ulrich S. Schubert, David Pretzel
Publikováno v: Bioconjugate Chemistry. 28:1229-1235
Controlling the size and charge of nanometer-sized objects is of upmost importance for their interactions with cells. We herein present the synthesis of poly(2-oxazoline) based nanogels comprising a hydrophilic shell and an amine containing core comp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc222526577e97b944ad28a5ce043173
https://doi.org/10.1021/acs.bioconjchem.7b00067
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6
Fluorescent amphiphilic heterografted comb polymers comprising biocompatible PLA and PEtOx side chains
Autor: Martin Sahn, Matthias Westerhausen, Diana Kalden, Tanja Bus, Ulrich S. Schubert, Christine Weber, Turgay Yildirim, Stephanie Hoeppener, Ilknur Yildirim, Anja Traeger
Publikováno v: Polymer Chemistry. 7:6064-6074
A series of amphiphilic heterografted comb polymers comprising various ratios of oligomeric polylactide (PLA) and poly(2-ethyl-2-oxazoline) (PEtOx) side chains was synthesized via the grafting-through method employing the reversible addition–fragme
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d6df1bffb7c962491270007b1feda27c
https://doi.org/10.1039/c6py01130f
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7
Tumor targeting with pH-responsive poly(2-oxazoline)-based nanogels for metronomic doxorubicin treatment
Autor: Ulrich S. Schubert, René Thierbach, Doerte Hoelzer, Tanja Bus, Stephanie Hoeppener, Kristian Kempe, Meike N. Leiske, David Pretzel, Matthias Hartlieb
Publikováno v: Hoelzer, D.; Leiske, M.N.; Hartlieb, M.; Bus, T.; Pretzel, D.; Hoeppener, S.; Kempe, K.; Thierbach, R.; Schubert, U.S.: Tumor targeting with pH-responsive poly(2-oxazoline)-based nanogels for metronomic doxorubicin treatment. In: Oncotarget. Vol. 9 (2018) 32, 22316-22331. (DOI: /10.18632/oncotarget.24806)
Oncotarget
The synthesis of a new nanogel drug carrier system loaded with the anti-cancer drug doxorubicin (DOX) is presented. Poly(2-oxazoline) (POx) based nanogels from block copolymer micelles were cross-linked and covalently loaded with DOX using pH-sensiti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb1b9c00645063e3af2b838f7cc7ea5f
https://publications.hzg.de/id/36359
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8
Crossing the blood-brain barrier: Glutathione-conjugated poly(ethylene imine) for gene delivery
Autor: Philipp S. Borchers, Martin Raasch, Alexander S. Mosig, Tanja Bus, Anne-Kristin Trützschler, Ulrich S. Schubert, Anja Traeger, Christoph Englert
Publikováno v: Journal of controlled release : official journal of the Controlled Release Society. 241
The targeted drug delivery to the central nervous system represents one of the major challenges in pharmaceutical formulations since it is strictly limited through the highly selective blood-brain barrier (BBB). l-Glutathione (GSH), a tripeptide and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37d77aced2863d536b522778d4b4fb6a
https://pubmed.ncbi.nlm.nih.gov/27586188
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9
Genetic transformation of Knufia petricola A95 - a model organism for biofilm-material interactions
Autor: Steffi, Noack-Schönmann, Tanja, Bus, Ronald, Banasiak, Nicole, Knabe, William J, Broughton, H, Den Dulk-Ras, Paul Jj, Hooykaas, Anna A, Gorbushina
Publikováno v: AMB Express
We established a protoplast-based system to transfer DNA to Knufia petricola strain A95, a melanised rock-inhabiting microcolonial fungus that is also a component of a model sub-aerial biofilm (SAB) system. To test whether the desiccation resistant,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::409e8d314b3b378a293c427a68412890
https://pubmed.ncbi.nlm.nih.gov/25401079
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10
COV434 granulosa cell line: take it or leave it?
Autor: Andreas Fritzsche, Tanja Bus, Ekkehard Schleussner, Jana Pastuschek, Georgiev Georgi S, Jenny Poetzsch, Udo R. Markert, Simone Winkler, Mariella Raabe
Publikováno v: Journal of Reproductive Immunology. :31
Journal of Reproductive Immunology 101–102 (2014) 18–39 31 Methods:The trophoblastmodel cell line JEG-3was cultured on a chamber slide and either untreated or treated with LPS, poly(I:C) and both together for 24h, and stained HLA-C, -E, and -G mo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::836a7f9d3781a00ffcdd1a0533427c27
https://doi.org/10.1016/j.jri.2013.12.102
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