Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Tanja, Schönberger"'
Autor:
Julia Sauer, Agnes A. Steixner-Kumar, Svenja Gabler, Maciej Motyka, Jörg F. Rippmann, Stefan Brosa, Dennis Boettner, Tanja Schönberger, Charlotte Lempp, Vanessa Frodermann, Eric Simon, Oliver Krenkel, Ehsan Bahrami
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Chronic liver diseases, such as non-alcoholic steatohepatitis (NASH)-induced cirrhosis, are characterized by an increasing accumulation of stressed, damaged, or dying hepatocytes. Hepatocyte damage triggers the activation of resident immune cells, su
Externí odkaz:
https://doaj.org/article/8f49c0488c064420b392c7d96dc7899e
Autor:
Matthias J. Düchs, Ramona F. Kratzer, Pablo Vieyra-Garcia, Benjamin Strobel, Tanja Schönberger, Peter Groß, Ghaith Aljayyoussi, Aradhana Gupta, Isabel Lang, Holger Klein, Sandra Martinez Morilla, Stefan Hopf, John Park, Sebastian Kreuz, Matthias Klugmann, Frederik H. Igney
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Hepatocellular carcinoma (HCC) and solid cancers with liver metastases are indications with high unmet medical need. Interleukin-12 (IL-12) is a proinflammatory cytokine with substantial anti-tumor properties, but its therapeutic potential has not be
Externí odkaz:
https://doaj.org/article/d7f68968ee5443eba85a103c30a0af1e
Autor:
Matthias Düchs, Dragica Blazevic, Philipp Rechtsteiner, Cynthia Kenny, Thorsten Lamla, Sarah Low, Jimmy Savistchenko, Manuela Neumann, Ronald Melki, Tanja Schönberger, Birgit Stierstorfer, David Wyatt, Frederik Igney, Thomas Ciossek
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-15 (2023)
Abstract Prion-like transmission of pathology in α-synucleinopathies like Parkinson’s disease or multiple system atrophy is increasingly recognized as one potential mechanism to address disease progression. Active and passive immunotherapies targe
Externí odkaz:
https://doaj.org/article/bfa18d4f4cb54bf398d1a6ddf489f5be
Autor:
Dalia Pakalniškytė, Tanja Schönberger, Benjamin Strobel, Birgit Stierstorfer, Thorsten Lamla, Michael Schuler, Martin Lenter
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Transgenic animals with increased or abrogated target gene expression are powerful tools for drug discovery research. Here, we developed a CRISPR-based Rosa26-LSL-dCas9-VPR mouse model for targeted induction of endogenous gene expression usi
Externí odkaz:
https://doaj.org/article/5f71560143154c38951bffbfbcaeeb5e
Autor:
Jonas Weinmann, Sabrina Weis, Josefine Sippel, Warut Tulalamba, Anca Remes, Jihad El Andari, Anne-Kathrin Herrmann, Quang H. Pham, Christopher Borowski, Susanne Hille, Tanja Schönberger, Norbert Frey, Martin Lenter, Thierry VandenDriessche, Oliver J. Müller, Marinee K. Chuah, Thorsten Lamla, Dirk Grimm
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Adeno-associated virus is the basis of many gene therapies and gene transfer vectors. Here the authors report a pipeline to enable side-by-side comparison of pre-selected capsids in a high throughput manner.
Externí odkaz:
https://doaj.org/article/fcda7a44d2044540880d0f383706efd9
Autor:
Julia F. Söllner, Germán Leparc, Matthias Zwick, Tanja Schönberger, Tobias Hildebrandt, Kay Nieselt, Eric Simon
Publikováno v:
BMC Medical Genomics, Vol 12, Iss 1, Pp 1-12 (2019)
Abstract Background The ability to generate recombinant drug target proteins is important for drug discovery research as it facilitates the investigation of drug-target-interactions in vitro. To accomplish this, the target’s exact protein sequence
Externí odkaz:
https://doaj.org/article/ea1ee743c46f4087b5d52424809c6211
Autor:
Anna-Kaisa Rimpelä, Michel Garneau, Katja S. Baum-Kroker, Tanja Schönberger, Frank Runge, Achim Sauer
Publikováno v:
Pharmaceutics, Vol 12, Iss 12, p 1174 (2020)
The rat is a commonly used species in ocular drug research. Detailed methods of separating rat ocular tissues have not been described in literature. To understand the intraocular drug distribution, we developed a robust method for the separation of i
Externí odkaz:
https://doaj.org/article/40c26c3a9cb9433e9e1f974a09ebe070
Autor:
Matthias Düchs, Dragica Blazevic, Philipp Rechtsteiner, Cynthia Kenny, Thorsten Lamla, Sarah Low, Jimmy Savistchenko, Manuela Neumann, Ronald Melki, Tanja Schönberger, Birgit Stierstorfer, David Wyatt, Frederik Igney, Thomas Ciossek
Prion-like transmission of pathology in α-synucleinopathies like Parkinson’s disease or multiple system atrophy is increasingly recognized as one potential mechanism to address disease progression. Active and passive immunotherapies targeting inso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8926442dadbf8f2667aede74b3b6140c
https://doi.org/10.1101/2022.11.30.518485
https://doi.org/10.1101/2022.11.30.518485
Autor:
Eva Griesser, Tanja Schönberger, Birgit Stierstorfer, Hannah Wyatt, Wolfgang Rist, Thorsten Lamla, Matthew James Thomas, David Lamb, Kerstin Geillinger-Kästle
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 323(2)
Animal models are important to mimic certain pathways or biological aspects of human pathologies including acute and chronic pulmonary diseases. We developed a novel and flexible mouse model of acute epithelial lung injury based on adeno-associated v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::111c521aa0a405581aba89f54ba9794c
https://pubmed.ncbi.nlm.nih.gov/35762632
https://pubmed.ncbi.nlm.nih.gov/35762632
Autor:
Dirk Grimm, Josefine Sippel, Quang H Pham, Marinee Chuah, Martin Lenter, Christopher Borowski, Susanne Hille, Oliver J. Müller, Norbert Frey, Jihad El Andari, Jonas Weinmann, Warut Tulalamba, Anca Remes, Thorsten Lamla, Sabrina Weis, Anne-Kathrin Herrmann, Thierry VandenDriessche, Tanja Schönberger
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications
Adeno-associated virus (AAV) forms the basis for several commercial gene therapy products and for countless gene transfer vectors derived from natural or synthetic viral isolates that are under intense preclinical evaluation. Here, we report a versat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9d2a3af711038dc222e94adf494d9dc
https://doaj.org/article/fcda7a44d2044540880d0f383706efd9
https://doaj.org/article/fcda7a44d2044540880d0f383706efd9