Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Tanja, Bedke"'
Autor:
Friederike Stumme, Niklas Steffens, Babett Steglich, Franziska Mathies, Mikolaj Nawrocki, Morsal Sabihi, Shiwa Soukou-Wargalla, Emilia Göke, Jan Kempski, Thorben Fründt, Sören Weidemann, Christoph Schramm, Nicola Gagliani, Samuel Huber, Tanja Bedke
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundPrimary sclerosing cholangitis (PSC) is a chronic liver disease marked by inflammation of the bile ducts and results in the development of strictures and fibrosis. A robust clinical correlation exists between PSC and inflammatory bowel dise
Externí odkaz:
https://doaj.org/article/fe4be545b6ce4708b789790c53a8eb4c
Autor:
Theresa Staufer, Christian Körnig, Beibei Liu, Yang Liu, Clarissa Lanzloth, Oliver Schmutzler, Tanja Bedke, Andres Machicote, Wolfgang J. Parak, Neus Feliu, Lidia Bosurgi, Samuel Huber, Florian Grüner
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract The infiltration of immune cells into sites of inflammation is one key feature of immune mediated inflammatory diseases. A detailed assessment of the in vivo dynamics of relevant cell subtypes could booster the understanding of this disease
Externí odkaz:
https://doaj.org/article/779313d9487d4d85b67210bf566a429d
Autor:
Anastasios D. Giannou, Jan Kempski, Tao Zhang, Jöran Lücke, Ahmad Mustafa Shiri, Dimitra E. Zazara, Ioannis Belios, Andres Machicote, Philipp Seeger, Theodora Agalioti, Joseph Tintelnot, Adrian Sagebiel, Miriam Tomczak, Lennart Bauditz, Tanja Bedke, Lorenz Kocheise, Baris Mercanoglu, Mohammad Fard-Aghaie, Emmanouil Giorgakis, Panagis M. Lykoudis, Anastasia Pikouli, Julia-Kristin Grass, Ramez Wahib, Jan Bardenhagen, Benjamin Brunswig, Asmus Heumann, Tarik Ghadban, Anna Duprée, Michael Tachezy, Nathaniel Melling, Petra C. Arck, Pablo Stringa, Maria Virginia Gentilini, Gabriel E. Gondolesi, Ryosuke Nakano, Angus W. Thomson, Daniel Perez, Jun Li, Oliver Mann, Jakob R. Izbicki, Nicola Gagliani, Ioannis C. Maroulis, Samuel Huber
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundThe immune system plays a pivotal role in cancer progression. Interleukin 22 binding protein (IL-22BP), a natural antagonist of the cytokine interleukin 22 (IL-22) has been shown to control the progression of colorectal cancer (CRC). Howeve
Externí odkaz:
https://doaj.org/article/f1277168178b412eb2f6bc3aef5b86d5
Autor:
Christian Körnig, Theresa Staufer, Oliver Schmutzler, Tanja Bedke, Andres Machicote, Beibei Liu, Yang Liu, Elisabetta Gargioni, Neus Feliu, Wolfgang J. Parak, Samuel Huber, Florian Grüner
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract X-ray fluorescence imaging (XFI) is a non-invasive detection method of small quantities of elements, which can be excited to emit fluorescence x-ray photons upon irradiation with an incident x-ray beam. In particular, it can be used to measu
Externí odkaz:
https://doaj.org/article/0be7b1ac37704fc585a14b01a1219476
Autor:
Marius Piepke, Bettina H. Clausen, Peter Ludewig, Jonas H. Vienhues, Tanja Bedke, Ehsan Javidi, Björn Rissiek, Larissa Jank, Leonie Brockmann, Inga Sandrock, Karoline Degenhardt, Alina Jander, Vanessa Roth, Ines S. Schädlich, Immo Prinz, Richard A. Flavell, Yasushi Kobayashi, Thomas Renné, Christian Gerloff, Samuel Huber, Tim Magnus, Mathias Gelderblom
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-16 (2021)
Abstract Background Lymphocytes have dichotomous functions in ischemic stroke. Regulatory T cells are protective, while IL-17A from innate lymphocytes promotes the infarct growth. With recent advances of T cell-subtype specific transgenic mouse model
Externí odkaz:
https://doaj.org/article/84eccf40e2484f5c8eb8bfa924fd98ed
Autor:
Laura Garcia Perez, Jan Kempski, Heather M. McGee, Penelope Pelzcar, Theodora Agalioti, Anastasios Giannou, Leonie Konczalla, Leonie Brockmann, Ramez Wahib, Hao Xu, Maria Carolina Amezcua Vesely, Shiwa Soukou, Babett Steglich, Tanja Bedke, Carolin Manthey, Oliver Seiz, Björn-Philipp Diercks, Stylianos Gnafakis, Andreas H. Guse, Daniel Perez, Jakob R. Izbicki, Nicola Gagliani, Richard A. Flavell, Samuel Huber
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Poly-functional helper T cells can have a stronger effect than mono-functional T cells, but whether the response is qualitatively different is not clear. Here the authors show that a population of IL-17+IL-22+, but not single IL-22+, CD4+ T cells are
Externí odkaz:
https://doaj.org/article/b2cd0a9890934f83bc2a0f45b98be1cc
Autor:
Niels C. Lory, Mikolaj Nawrocki, Martina Corazza, Joanna Schmid, Valéa Schumacher, Tanja Bedke, Stephan Menzel, Friedrich Koch-Nolte, Andreas H. Guse, Samuel Huber, Hans-Willi Mittrücker
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Antigen recognition by the T-cell receptor induces a cytosolic Ca2+ signal that is crucial for T-cell function. The Ca2+ channel TRPM2 (transient receptor potential cation channel subfamily M member 2) has been shown to facilitate influx of extracell
Externí odkaz:
https://doaj.org/article/5c28e5bc8b0942f7974a02595a93de41
Autor:
Leonie Brockmann, Shiwa Soukou, Babett Steglich, Paulo Czarnewski, Lilan Zhao, Sandra Wende, Tanja Bedke, Can Ergen, Carolin Manthey, Theodora Agalioti, Maria Geffken, Oliver Seiz, Sara M. Parigi, Chiara Sorini, Jens Geginat, Keishi Fujio, Thomas Jacobs, Thomas Roesch, Jacob R. Izbicki, Ansgar W. Lohse, Richard A. Flavell, Christian Krebs, Jan-Ake Gustafsson, Per Antonson, Maria Grazia Roncarolo, Eduardo J. Villablanca, Nicola Gagliani, Samuel Huber
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Tr1 cells are considered an immunosuppressive CD4 T cell population producing IL-10. Here the authors show that IL-10 is insufficient for Tr1 immunosuppression, define surface markers and transcriptional program of the immunosuppressive subset within
Externí odkaz:
https://doaj.org/article/9965d7bfb0694a05899ad6316109497d
Autor:
Mikołaj Nawrocki, Niels Lory, Tanja Bedke, Friederike Stumme, Björn-Phillip Diercks, Andreas H. Guse, Chris Meier, Nicola Gagliani, Hans-Willi Mittrücker, Samuel Huber
Publikováno v:
Cells, Vol 10, Iss 11, p 3039 (2021)
Nicotinic acid adenine dinucleotide phosphate (NAADP) is the most potent Ca2+ mobilizing agent and its inhibition proved to inhibit T-cell activation. However, the impact of the NAADP signaling on CD4+ T-cell differentiation and plasticity and on the
Externí odkaz:
https://doaj.org/article/800f263d5f3a4bb294d1ec4fe5002247
Autor:
Laura Garcia Perez, Jan Kempski, Heather M. McGee, Penelope Pelzcar, Theodora Agalioti, Anastasios Giannou, Leonie Konczalla, Leonie Brockmann, Ramez Wahib, Hao Xu, Maria Carolina Amezcua Vesely, Shiwa Soukou, Babett Steglich, Tanja Bedke, Carolin Manthey, Oliver Seiz, Björn-Philipp Diercks, Stylianos Gnafakis, Andreas H. Guse, Daniel Perez, Jakob R. Izbicki, Nicola Gagliani, Richard A. Flavell, Samuel Huber
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-2 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/2cd023103209408b997979cd8e61dbda