Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Tanios S. Bekaii-Saab"'
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 16 (2024)
Colorectal cancer is a leading cause of cancer-related mortality worldwide. Approximately 3–5% of colorectal tumors harbor human epidermal growth factor receptor ( HER2 ) amplification which is associated with a higher incidence of intracranial met
Externí odkaz:
https://doaj.org/article/e91cb5e5fde44ee696a37892d208ee0a
Autor:
Tara L. Hogenson, Hao Xie, William J. Phillips, Merih D. Toruner, Jenny J. Li, Isaac P. Horn, Devin J. Kennedy, Luciana L. Almada, David L. Marks, Ryan M. Carr, Murat Toruner, Ashley N. Sigafoos, Amanda N. Koenig-Kappes, Rachel L.O. Olson, Ezequiel J. Tolosa, Cheng Zhang, Hu Li, Jason D. Doles, Jonathan Bleeker, Michael T. Barrett, James H. Boyum, Benjamin R. Kipp, Amit Mahipal, Joleen M. Hubbard, Temperance J. Scheffler Hanson, Gloria M. Petersen, Surendra Dasari, Ann L. Oberg, Mark J. Truty, Rondell P. Graham, Michael J. Levy, Mojun Zhu, Daniel D. Billadeau, Alex A. Adjei, Nelson Dusetti, Juan L. Iovanna, Tanios S. Bekaii-Saab, Wen Wee Ma, Martin E. Fernandez-Zapico
Publikováno v:
JCI Insight, Vol 7, Iss 22 (2022)
BACKGROUND A patient-derived organoid (PDO) platform may serve as a promising tool for translational cancer research. In this study, we evaluated PDO’s ability to predict clinical response to gastrointestinal (GI) cancers.METHODS We generated PDOs
Externí odkaz:
https://doaj.org/article/f973dfbdbe53458f81a1c8da0742e768
Publikováno v:
Therapeutic Advances in Gastroenterology, Vol 15 (2022)
Hepatocellular carcinoma (HCC) is the fastest increasing cause of cancer-related mortality in the United States and is projected to be the third leading cause of cancer-related mortality in the United States by 2030. Main risk factors include alcohol
Externí odkaz:
https://doaj.org/article/89be4af734fe46e5af4905f244c9fc29
Autor:
Gehan Botrus, Pedro Luiz Serrano Uson Junior, Puneet Raman, Adrienne E. Kaufman, Heidi Kosiorek, Jun Yin, Yu Fu, Umair Majeed, Mohamad Bassam Sonbol, Daniel H. Ahn, Isabela W. Chang, Leylah M. Drusbosky, Hiba Dada, Jason Starr, Mitesh Borad, Kabir Mody, Tanios S. Bekaii-Saab
Publikováno v:
Frontiers in Oncology, Vol 11 (2022)
BackgroundPlasma-based circulating cell-free tumor DNA (ctDNA) genomic profiling by next-generation sequencing (NGS)is an emerging diagnostic tool for pancreatic cancer (PC). The impact of detected genomic alterations and variant allele fraction (VAF
Externí odkaz:
https://doaj.org/article/3c929f228f60402d8f1231afe13e69c0
Autor:
Daniel Walden, Mohamad Bassam Sonbol, Skye Buckner Petty, Harry H. Yoon, Mitesh Borad, Tanios S. Bekaii-Saab, Daniel H. Ahn
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
BackgroundFluoropyrimidine with platinum-based chemotherapy has become the standard of care for advanced gastric and gastroesophageal (GEJ) cancer. Trials in colon cancer show that induction chemotherapy followed by maintenance chemotherapy is an eff
Externí odkaz:
https://doaj.org/article/01f60d4e3190474e91faeb189c39f67a
Autor:
Michael H. Storandt, Jennifer J. Gile, Mathias E. Palmer, Tyler J. Zemla, Daniel H. Ahn, Tanios S. Bekaii-Saab, Zhaohui Jin, Nguyen H. Tran, Amit Mahipal
Publikováno v:
Cancers, Vol 14, Iss 21, p 5173 (2022)
(1) Background: Cabozantinib, a multikinase inhibitor, is approved by the Food and Drug Administration (FDA) for the treatment of advanced hepatocellular carcinoma (HCC) following progression on sorafenib. Recently, atezolizumab plus bevacizumab has
Externí odkaz:
https://doaj.org/article/8e97c2bbf97e4f15b393a180710f1d3f
Autor:
Cassia B. Wang, Faisal Shahjehan, Amit Merchea, Zhuo Li, Tanios S. Bekaii-Saab, Axel Grothey, Dorin T. Colibaseanu, Pashtoon M. Kasi
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Background: Our study investigated the demographic characteristics of Mayo Clinic Colon and Rectal Cancer Registry patients and sought to associate tumor location with overall survival.Methods: Using the cohort of patients seen at Mayo Clinic (Minnes
Externí odkaz:
https://doaj.org/article/3132622d539a4ee69fd4e2e79b4af08b
Autor:
Bashir Lawal, Li-Ching Lin, Jih-Chin Lee, Jia-Hong Chen, Tanios S. Bekaii-Saab, Alexander T. H. Wu, Ching-Liang Ho
Publikováno v:
Cancers, Vol 13, Iss 5, p 954 (2021)
Signal transducer and activator of transcription 3 (STAT3)/Cyclin-dependent kinases are multifunctional proteins that play an important implicative role in cancer initiations, progression, drug resistance, and metastasis, and has been extensively exp
Externí odkaz:
https://doaj.org/article/eaa8671f041e422887418b4255829063
Autor:
Craig L Slingluff, Gina R Petroni, Todd Bauer, Nipun Merchant, Osama Rahma, Rawad Elias, Scott Rodig, Matthew H G Katz, Andressa Dias Costa, Brian M Wolpin, Stephanie K Dougan, Chee-Chee Stucky, Kathleen Pfaff, Gauri R Varadhachary, Victoire Cardot-Ruffino, Matthew J Reilley, Patrick Lenehan, Tanios S Bekaii-Saab, Jonathan Andrew Nowak
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 12 (2023)
Background Pancreatic ductal adenocarcinoma (PDAC) is a challenging target for immunotherapy because it has an immunosuppressive tumor microenvironment. Neoadjuvant chemoradiotherapy can increase tumor-infiltrating lymphocyte (TIL) density, which may
Externí odkaz:
https://doaj.org/article/9581129e54704c9a868c55f1b44e76c3
Autor:
John H Strickler, Andrea Cercek, Salvatore Siena, Thierry André, Kimmie Ng, Eric Van Cutsem, Christina Wu, Andrew S Paulson, Joleen M Hubbard, Andrew L Coveler, Christos Fountzilas, Adel Kardosh, Pashtoon M Kasi, Heinz-Josef Lenz, Kristen K Ciombor, Elena Elez, David L Bajor, Chiara Cremolini, Federico Sanchez, Michael Stecher, Wentao Feng, Tanios S Bekaii-Saab, Marc Peeters, Marc Van den Evnde, Christophe Borg, Matthieu Sarabi, Francois Ghiringhelli, Benoist Chibaudel, Maria G. Zampino, Susana R. Keranen, Ramon Salazar, Pilar Alfonso, John H. Strickler, Andrew S. Paulson, Joleen M. Hubbard, Andrew L. Coveler, Pashtoon M. Kasi, Kristen K. Ciombor, David L. Bajor, Tanios S. Bekaii-Saab, Olumide Gbolahan, Patrick Boland, Daniel Berg, Timothy Goggins, Anwar Saeed, Howard Burris, Johanna Bendell, Darryl Outlaw, Isaac Tafur, Ardaman Shergill, Daniel Catenacci, Jun Gong, Ignacio Garrido-Laguna, Gene Finley, Benjamin Weinberg, Anthony Shields, Philip Philip, Anita Turk, Anthony Nguyen, Fadi Braiteh, Vijay Patel, William Harwin, Ian Anderson, Ajay Kundra, Christopher Chen, James Ford, Madappa Kundranda, Danny Nguyen, Suresh Ratnam, Donald Richards, Sujatha Nallapareddy, Sridhar Beeram, Scott McKenney, Spencer Shao
Publikováno v:
The Lancet Oncology. 24:496-508