Výsledky vyhledávání - "Tanila, Ben Haddou"

Akademický článek

Induction of Multidrug Tolerance in Plasmodium falciparum by Extended Artemisinin Pressure

Autor: Sandie Ménard, Tanila Ben Haddou, Arba Pramundita Ramadani, Frédéric Ariey, Xavier Iriart, Johann Beghain, Christiane Bouchier, Benoit Witkowski, Antoine Berry, Odile Mercereau-Puijalon, Françoise Benoit-Vical

Publikováno v: Emerging Infectious Diseases, Vol 21, Iss 10, Pp 1733-1741 (2015)

Plasmodium falciparum resistance to artemisinin derivatives in Southeast Asia threatens global malaria control strategies. Whether delayed parasite clearance, which exposes larger parasite numbers to artemisinins for longer times, selects higher-grad

Externí odkaz: https://doaj.org/article/5fad171e68444e7c8cce845eacc52d24

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Akademický článek

Pharmacological investigations of N-substituent variation in morphine and oxymorphone: opioid receptor binding, signaling and antinociceptive activity.

Autor: Tanila Ben Haddou, Szabolcs Béni, Sándor Hosztafi, Davide Malfacini, Girolamo Calo, Helmut Schmidhammer, Mariana Spetea

Publikováno v: PLoS ONE, Vol 9, Iss 6, p e99231 (2014)

Morphine and structurally related derivatives are highly effective analgesics, and the mainstay in the medical management of moderate to severe pain. Pharmacological actions of opioid analgesics are primarily mediated through agonism at the µ opioid

Externí odkaz: https://doaj.org/article/a73325779fbe481cbacb806a8cd04d23

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Injectable peptide hydrogels for controlled-release of opioids

Autor: Steven Ballet, Mathieu Bibian, Richard Hoogenboom, Tanila Ben Haddou, Edith Oyen, James Gardiner, Mariana Spetea, Charlotte Martin, Bruno Van Mele, Annemieke Madder, Jessica Andrade, Jeroen Mangelschots

Publikováno v: MedChemComm. 7:542-549

Herein, a family of hydrogel-forming peptides was designed starting from the short, tunable and amphipathic hexapeptide hydrogelator H-Phe-Glu-Phe-Gln-Phe-Lys-OH (1). The hydrophobic side chains as well as the nature of both N- and C-termini were mod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b072715aebf078314fd479cf2e577e2
https://doi.org/10.1039/c5md00440c

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Anti-inflammatory effect of dual nociceptin and opioid receptor agonist, BU08070, in experimental colitis in mice

Autor: Mariana Spetea, Tanila Ben Haddou, Gerta Cami-Kobeci, Radzisław Kordek, Stephen M. Husbands, Agata Jarmuż, Maciej Sałaga, Milena Padysz, Marta Zielińska, Jakub Fichna

Publikováno v: European Journal of Pharmacology. 765:582-590

Endogenous opioid and nociceptin systems are widely distributed in the gastrointestinal tract where they seem to play a crucial role in maintaining the intestinal homeostasis. The aim of our study was to assess whether activation of nociceptin (NOP)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb36797e5962d4b268b114dc0c4ad3b7
https://doi.org/10.1016/j.ejphar.2015.09.021

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Synthesis, Pharmacology, and Molecular Docking Studies on 6-Desoxo-N-methylmorphinans as Potent μ-Opioid Receptor Agonists

Autor: Maria, Dumitrascuta, Tanila, Ben Haddou, Elena, Guerrieri, Stefan M, Noha, Lea, Schläfer, Helmut, Schmidhammer, Mariana, Spetea

Publikováno v: Journal of Medicinal Chemistry

Position 6 of the morphinan skeleton plays a key role in the μ-opioid receptor (MOR) activity in vitro and in vivo. We describe the consequence of the 6-carbonyl group deletion in N-methylmorphinan-6-ones 1–4 on ligand–MOR interaction, signaling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::79b5b040f59c3345eb1b02f4505a6477
https://pubmed.ncbi.nlm.nih.gov/29053268

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Endoperoxide-based compounds: cross-resistance with artemisinins and selection of a Plasmodium falciparum lineage with a K13 non-synonymous polymorphism

Autor: Françoise Benoit-Vical, Anne Robert, Jean-Michel Augereau, Manel Ouji, Joël Lelièvre, Lucie Paloque, Didier Menard, Tanila Ben Haddou, Frédéric Ariey, Bernard Meunier, Benoit Witkowski

Publikováno v: Journal of Antimicrobial Chemotherapy
Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), 2018, 73 (2), pp.395-403. ⟨10.1093/jac/dkx412⟩

International audience; Background: Owing to the emergence of multiresistant Plasmodium falciparum parasites in Southeast Asia, along with the impressive decrease in the efficacy of the endoperoxide compound artemisinin and of artemisinin-based combi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dcffc96275d39a357cd070ca1b81f4e
https://pubmed.ncbi.nlm.nih.gov/29177421

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Exploring pharmacological activities and signaling of morphinans substituted in position 6 as potent agonists interacting with the μ opioid receptor

Autor: Tanila, Ben Haddou, Davide, Malfacini, Girolamo, Calo, Mario D, Aceto, Louis S, Harris, John R, Traynor, Andrew, Coop, Helmut, Schmidhammer, Mariana, Spetea

Publikováno v: Molecular Pain

Background Opioid analgesics are the most effective drugs for the treatment of moderate to severe pain. However, they also produce several adverse effects that can complicate pain management. The μ opioid (MOP) receptor, a G protein-coupled receptor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d8b1a83185ee60226b3706a45c92cb43
https://pubmed.ncbi.nlm.nih.gov/25059282

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Influence of the 14-alkoxy group and the substitution in position 5 in N-methyl-14-alkoxymorphinan-6-ones on in vitro and in vivopharmacological activities

Autor: Tanila Ben Haddou, Roberta Lattanzi, Helmut Schmidhammer, Mariana Spetea, Lucia Negri

Publikováno v: BMC Pharmacology & Toxicology

Background Opioid analgesics are the cornerstone drugs for the treatment of moderate-to-severe pain. Morphine and other analgesics like fentanyl, oxycodone and oxymorphone activate the μ opioid (MOP) receptor, the main type targeted for pharmacother

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b972fa54019e03ad001126715a9346e
https://doi.org/10.1186/2050-6511-13-s1-a33

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