Zobrazeno 1 - 10 of 74 pro vyhledávání: '"Tanikolide"'
1
Investigation of the Anti-Methicillin-Resistant Staphylococcus aureus Activity of (+)-Tanikolide- and (+)-Malyngolide-Based Analogues Prepared by Asymmetric Synthesis
Autor: Marta Martins, João Anes, Patrick J. Guiry, Cian Kingston, Robert Doran, Séamus Fanning, Joseph Breheny
Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 6400, p 6400 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 12
Herein, we report antibacterial and antifungal evaluation of a series of previously prepared (+)-tanikolide analogues. One analogue, (4S,6S)-4-methyltanikolide, displayed promising anti-methicillin-resistant Staphylococcus aureus activity with a MIC
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::756ba95e6fce57d2286ac03fde7de39b
https://doi.org/10.3390/ijms22126400
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2
Divergent synthesis of (+)-tanikolide and its analogues employing stereoselective rhodium(II)-catalyzed reaction
Autor: Hisanori Nambu, Tomoya Fujiwara, Takayuki Yakura, Hikari Jinnouchi
Publikováno v: Tetrahedron. 74:1059-1070
In this study, we described the divergent synthesis of (+)-tanikolide and its analogues, such as (4S)- and (4R)-hydroxytanikolides, and nortanikolide, employing a stereoselective dirhodium(II)-catalyzed reaction to construct the quaternary chiral cen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e15e97889856d27a02ce47a0bd8765fc
https://doi.org/10.1016/j.tet.2018.01.035
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3
Akademický článek
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4
Asymmetric Synthesis of (+)-Tanikolide and the β-Methyl-Substituted Analogues of (+)-Tanikolide and (-)-Malyngolide
Autor: Colm D. Duffy, Patrick J. Guiry, Surrendra Singh, Lesley Duggan, Robert Doran
Publikováno v: European Journal of Organic Chemistry. 2011:7097-7106
The δ-lactone-containing natural product (+)-tanikolide, a brine shrimp toxin and antifungal compound, was synthesized in nine steps with an overall yield of 26.4 % by employing Sharpless asymmetric epoxidation and ZrCl4-catalyzed intramolecular ace
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ae7fe9825bcaaa7c7807caa8abf2d0d3
https://doi.org/10.1002/ejoc.201101190
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5
Akademický článek
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6
Organometallation of (R)-2,3-cyclohexylideneglyceraldehyde derived ketones: a simple and stereoselective strategy for the synthesis of (+)-tanikolide
Autor: Angshuman Chattopadhyay, Prasad Vichare
Publikováno v: Tetrahedron: Asymmetry. 19:598-602
Several metal mediated allylations and Grignard additions to ketones 3 and 5 , both derived from ( R )-2,3-cylcohexylideneglyceraldehyde, took place with very high diastereoselectivity producing the same tertiary carbinol 4b as the major product. Sub
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cb7dd0be5c155c2d832c08a812fc0540
https://doi.org/10.1016/j.tetasy.2008.01.034
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8
Asymmetric Synthesis of the β-Methyl-Substituted Analogues of (+)-Tanikolide and (–)-Malyngolide
Autor: Robert Doran
Publikováno v: Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis of α-Aryl Ketones ISBN: 9783319205434
The asymmetric synthesis of all 4 diastereomers of β-methyl analogues of the marine natural products (+)-tanikolide, which displays antifungal activity, and (−)-malyngolide, which displays antimicrobial activity, has been successfully carried out.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4649479f035a42d7c2b2b81847ff8f86
https://doi.org/10.1007/978-3-319-20544-1_2
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10
Stereoselective synthesis of (−)-malyngolide, (+)-malyngolide and (+)-tanikolide using ring-closing metathesis
Autor: J. Alberto Marco, Alejandro Bellido, Encarnación Castillo, Miguel Carda, Santiago Díaz-Oltra, Santiago Rodriguez
Publikováno v: Tetrahedron. 59:857-864
The stereoselective syntheses of the naturally occurring δ-lactones (+)-tanikolide and (−)-malyngolide as well as of the unnatural (+)-enantiomer of the latter are described. Key steps in each of these syntheses were stereoselective additions of o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5416486fe1e716841c265ce6063476ea
https://doi.org/10.1016/s0040-4020(02)01594-6
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