The Loss of TGF-β Signaling Promotes Prostate Cancer Metastasis

Autor: William H. Tu, Tania Z. Thomas, Naoya Masumori, Neil A. Bhowmick, Agnieszka E. Gorska, Yu Shyr, Susan Kasper, Tom Case, Richard L. Roberts, Scott B. Shappell, Harold L. Moses, Robert J. Matusik

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 5, Iss 3, Pp 267-277 (2003)

In breast and colon cancers, transforming growth factor (TGIF)-β signaling initially has an antineoplastic effect, inhibiting tumor growth, but eventually exerts a proneoplastic effect, increasing motility and cancer spread. In prostate cancer, stud

Externí odkaz: https://doaj.org/article/21c9026b66d14b448573f894acef92c2

A Small Composite Probasin Promoter Confers High Levels of Prostate-Specific Gene Expression through Regulation by Androgens and Glucocorticoids in Vitro and in Vivo**This work was supported by R01-DK-55748 from the NIH and the Frances Williams Preston Laboratories of the T. J. Martell Foundation. Transgenic mice were bred by the Transgenic Core/ES Cell Shared Resource of the Vanderbilt-Ingram Cancer Center (NCI Grant 2P30-CA-68485–05)

Autor: Susan Kasper, Robert J. Matusik, JianFeng Zhang, Tania Z. Thomas

Publikováno v: Endocrinology. 141:4698-4710

Transient transfection studies have shown that the probasin (PB) promoter confers androgen selectivity over other steroid hormones, and transgenic animal studies have demonstrated that the PB promoter will target androgen, but not glucocorticoid, reg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::061e6720d5d97bb26ccefce9335f616e
https://doi.org/10.1210/endo.141.12.7837

Growth inhibitory response to activin A and B by human prostate tumour cell lines, LNCaP and DU145

Autor: Hong Wang, Stephen John McPherson, Tania Z Thomas, Chanran J Gurusinghe, Gail P. Risbridger

Publikováno v: Journal of Endocrinology. 154:535-545

Activins are growth and differentiation factors which have been shown to have proliferative and antiproliferative actions in many tissues. In addition, they have been implicated in tumourigenesis in reproductive tissues. Although activin and inhibin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12bd1002be1b47c28ebaecd532f33c19
https://doi.org/10.1677/joe.0.1540535

Transgenic Mouse Models of Prostate Cancer

Autor: Robert J. Matusik, Manik Paul, Susan Kasper, Thomas C. Case, Tania Z. Thomas, Scott B. Shappell, Naoya Masumori

Publikováno v: Transgenics in Endocrinology ISBN: 9781468496406

The reproductive organs are not required for an individual’s survival but are required for survival of the species. As the individual approaches adulthood, the prostate undergoes developmental changes, resulting in maturation of this gland at puber

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b599f1a3d6aa8524bde30a1a682fa01e
https://doi.org/10.1385/1-59259-102-7:401

A 5-kilobase pair promoter fragment of the murine epididymal retinoic acid-binding protein gene drives the tissue-specific, cell-specific, and androgen-regulated expression of a foreign gene in the epididymis of transgenic mice

Autor: Jean-Jacques Lareyre, David E. Ong, Susan Kasper, Robert J. Matusik, Wen-Li Zheng, Marie-Claire Orgebin-Crist, Tania Z. Thomas

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 1999, 274 (12), pp.8282-8290. ⟨10.1074/jbc.274.12.8282⟩
Journal of Biological Chemistry 12 (274), 8282-8290. (1999)

The murine epididymis synthesizes and secretes a retinoic acid-binding protein (mE-RABP) that belongs to the lipocalin superfamily. The gene encoding mE-RABP is specifically expressed in the mouse mid/distal caput epididymidis under androgen control.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a8c8802efc781a1934b674295758669
https://pubmed.ncbi.nlm.nih.gov/10075734