Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Tania Santoro"'
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Akademický článek
Connexin37‐Dependent Mechanisms Selectively Contribute to Modulate Angiotensin II‐Mediated Hypertension
Autor: Loïc Le Gal, Maxime Pellegrin, Tania Santoro, Lucia Mazzolai, Armin Kurtz, Paolo Meda, Charlotte Wagner, Jacques‐Antoine Haefliger
Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 8 (2019)
Background Gap junction channels made of Connexin37 (Cx37) are expressed by aortic endothelial and smooth muscle cells of hypertensive mice, as well as by the renin‐secreting cells of kidneys. Methods and Results To decipher whether Cx37 has any ro
Externí odkaz: https://doaj.org/article/a237c2aead0840e28fdf9fe8a7569937
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2
Targeting connexin37 alters angiogenesis and arteriovenous differentiation in the developing mouse retina
Autor: Lauriane Hamard, Denise Nardelli-Haefliger, Paolo Meda, Tania Santoro, Florent Allagnat, Florian Alonso, Jacques-Antoine Haefliger
Publikováno v: The FASEB Journal. 34:8234-8249
Connexin37 (Cx37) forms intercellular channels between endothelial cells (EC), and contributes to coordinate the motor tone of vessels. We investigated the contribution of this protein during physiological angiogenesis. We show that, compared to WT l
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0b76c43c22a2a553e24b96d7e1b5d80
https://doi.org/10.1096/fj.202000257r
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3
Targeting Endothelial Connexin37 Reduces Angiogenesis and Decreases Tumor Growth
Autor: Karthik Sathiyanadan, Florian Alonso, Sonia Domingos-Pereira, Tania Santoro, Lauriane Hamard, Valérie Cesson, Paolo Meda, Denise Nardelli-Haefliger, Jacques-Antoine Haefliger
Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 6; Pages: 2930
Connexin37 (Cx37) and Cx40 form intercellular channels between endothelial cells (EC), which contribute to the regulation of the functions of vessels. We previously documented the participation of both Cx in developmental angiogenesis and have furthe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90f906b9d0d41ba59d67111255f71722
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4
Rebound pathway overactivation by cancer cells following discontinuation of PI3K or mTOR inhibition promotes cancer cell growth
Autor: Olga De Souza Silva, Olivier Dormond, Tania Santoro, Seraina Faes, Laetitia Troquier
Publikováno v: Biochemical and biophysical research communications, vol. 513, no. 3, pp. 546-552
Whilst effects of anti-cancer drugs have been thoroughly explored, little is known about the repercussion of drug cessation. However, this has important clinical relevance since several clinical protocols such as intermittent drug scheduling lead to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d50127f306a84e9b0f9602438657ddcb
https://doi.org/10.1016/j.bbrc.2019.04.044
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5
Connexin37‐Dependent Mechanisms Selectively Contribute to Modulate Angiotensin II‐Mediated Hypertension
Autor: Armin Kurtz, Loïc Le Gal, Charlotte Wagner, Jacques-Antoine Haefliger, Maxime Pellegrin, Lucia Mazzolai, Paolo Meda, Tania Santoro
Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Journal of the American Heart Association, vol. 8, no. 8, pp. e010823
Background Gap junction channels made of Connexin37 (Cx37) are expressed by aortic endothelial and smooth muscle cells of hypertensive mice, as well as by the renin‐secreting cells of kidneys. Methods and Results To decipher whether Cx37 has any ro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62af2eab2bfa78523c1ba0f790f9de46
http://europepmc.org/articles/PMC6507190
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6
Targeting carbonic anhydrase IX improves the anti-cancer efficacy of mTOR inhibitors
Autor: Seraina Faes, Tania Santoro, Dipak Datta, Nicolo Riggi, Jean-Christophe Stehle, Catherine Pythoud, Janine Horlbeck, Emilie Uldry, Anne Planche, Nicolas Demartines, Igor Letovanec, Olivier Dormond
Publikováno v: Oncotarget, vol. 7, no. 24, pp. 36666-36680
Oncotarget
The inhibition of the mechanistic target of rapamycin complex 1 (mTORC1) by chemical inhibitors, such as rapamycin, has demonstrated anti-cancer activity in preclinical and clinical trials. Their efficacy is, however, limited and tumors eventually re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7298bff68a3e050003e44a3299b1b36
https://doi.org/10.18632/oncotarget.9134
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7
mTOR and Tumor Cachexia
Autor: Olivier Dormond, Tania Santoro, Cheryl Jeanneret, Adrian P. Duval
Publikováno v: International Journal of Molecular Sciences, Vol 19, Iss 8, p 2225 (2018)
International Journal of Molecular Sciences
Cancer cachexia affects most patients with advanced forms of cancers. It is mainly characterized by weight loss, due to muscle and adipose mass depletion. As cachexia is associated with increased morbidity and mortality in cancer patients, identifyin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc8f1e525f760f88d498e5e5c56897e4
http://www.mdpi.com/1422-0067/19/8/2225
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8
Acidic pH reduces VEGF-mediated endothelial cell responses by downregulation of VEGFR-2; relevance for anti-angiogenic therapies
Autor: Nicolas Demartines, Tania Santoro, Seraina Faes, Olivier Dormond, Emilie Uldry, Anne Planche, Catherine Pythoud
Publikováno v: Oncotarget
Oncotarget, vol. 7, no. 52, pp. 86026-86038
// Seraina Faes 1 , Emilie Uldry 1 , Anne Planche 1 , Tania Santoro 1 , Catherine Pythoud 1 , Nicolas Demartines 1 , Olivier Dormond 1 1 Department of Visceral Surgery, University Hospital of Lausanne, Switzerland Correspondence to: Olivier Dormond,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4f8439a88d690826077147dfb4e3b72
https://pubmed.ncbi.nlm.nih.gov/27852069
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9
Acidic tumor microenvironment abrogates the efficacy of mTORC1 inhibitors
Autor: Seraina Faes, Catherine Pythoud, Janine Horlbeck, Nicolas Demartines, Nicolo Riggi, Emilie Uldry, Tania Santoro, Igor Letovanec, Olivier Dormond, Jean-Christophe Stehle, Adrian P. Duval, Anne Planche
Publikováno v: Molecular Cancer
Molecular cancer, vol. 15, no. 1, pp. 78
Europe PubMed Central
Background: Blocking the mechanistic target of rapamycin complex-1 (mTORC1) with chemical inhibitors such as rapamycin has shown limited clinical efficacy in cancer. The tumor microenvironment is characterized by an acidic pH which interferes with ca
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0a38040ac493a5b66950be7aa66951c
https://pubmed.ncbi.nlm.nih.gov/27919264
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10
Evolving Significance and Future Relevance of Anti-Angiogenic Activity of mTOR Inhibitors in Cancer Therapy
Autor: Nicolas Demartines, Olivier Dormond, Seraina Faes, Tania Santoro
Publikováno v: Cancers
Cancers, Vol 9, Iss 11, p 152 (2017)
mTOR inhibitors have demonstrated remarkable anti-tumor activity in experimental models, mainly by reducing cancer cell growth and tumor angiogenesis. Their use in cancer patients as monotherapy has, however, generated only limited benefits, increasi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c972ce986ef9cdc6abc92bca313830a5
https://doi.org/10.3390/cancers9110152
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