Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Tania Sanchez-Perez"'
Autor:
Manuel Hidalgo, Jorge L. Martínez-Torrecuadrada, Orlando Domínguez, Antonio Cubillo, Carmen Blanco-Aparicio, Daniel Lietha, Alba De Martino, Rafael Álvarez, Sofia Perea, Tania Sanchez-Perez, Marta Camacho-Artacho, Francesca Sarno, Victoria Bonilla, Yolanda Durán, Natalia Baños, Maria I. Albarran, Álvaro Otero, Estela Vega, Jorge Monsech, Tirso Pons, Maria Mitsi, Elena Garralda, Rodrigo A. Toledo
Figure S1: Read alignments from WES-cfDNA, showing somatic mutations in APC and TP53 genes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fa8a275edf2ccc5641903966c9c42f0
https://doi.org/10.1158/1078-0432.22474737
https://doi.org/10.1158/1078-0432.22474737
Autor:
Manuel Hidalgo, Jorge L. Martínez-Torrecuadrada, Orlando Domínguez, Antonio Cubillo, Carmen Blanco-Aparicio, Daniel Lietha, Alba De Martino, Rafael Álvarez, Sofia Perea, Tania Sanchez-Perez, Marta Camacho-Artacho, Francesca Sarno, Victoria Bonilla, Yolanda Durán, Natalia Baños, Maria I. Albarran, Álvaro Otero, Estela Vega, Jorge Monsech, Tirso Pons, Maria Mitsi, Elena Garralda, Rodrigo A. Toledo
Legends for Supplementary Figures 1-6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bd4e5e8a1416dde19adba9169bae983
https://doi.org/10.1158/1078-0432.22474719
https://doi.org/10.1158/1078-0432.22474719
Autor:
Manuel Hidalgo, Jorge L. Martínez-Torrecuadrada, Orlando Domínguez, Antonio Cubillo, Carmen Blanco-Aparicio, Daniel Lietha, Alba De Martino, Rafael Álvarez, Sofia Perea, Tania Sanchez-Perez, Marta Camacho-Artacho, Francesca Sarno, Victoria Bonilla, Yolanda Durán, Natalia Baños, Maria I. Albarran, Álvaro Otero, Estela Vega, Jorge Monsech, Tirso Pons, Maria Mitsi, Elena Garralda, Rodrigo A. Toledo
Table S3: Treatment regimens of the Avatar patient derived xenograft models carrying the VEGFR2 WT and L840F genotypes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e5b1ffda916b06e2af3d75c14ab922c
https://doi.org/10.1158/1078-0432.22474704.v1
https://doi.org/10.1158/1078-0432.22474704.v1
Autor:
Manuel Hidalgo, Jorge L. Martínez-Torrecuadrada, Orlando Domínguez, Antonio Cubillo, Carmen Blanco-Aparicio, Daniel Lietha, Alba De Martino, Rafael Álvarez, Sofia Perea, Tania Sanchez-Perez, Marta Camacho-Artacho, Francesca Sarno, Victoria Bonilla, Yolanda Durán, Natalia Baños, Maria I. Albarran, Álvaro Otero, Estela Vega, Jorge Monsech, Tirso Pons, Maria Mitsi, Elena Garralda, Rodrigo A. Toledo
Figure S2: Read alignments from WES-cfDNA, showing somatic mutations in APC and TP53 genes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bad121a403acc5b53cd2610053591c1
https://doi.org/10.1158/1078-0432.22474734.v1
https://doi.org/10.1158/1078-0432.22474734.v1
Autor:
Manuel Hidalgo, Jorge L. Martínez-Torrecuadrada, Orlando Domínguez, Antonio Cubillo, Carmen Blanco-Aparicio, Daniel Lietha, Alba De Martino, Rafael Álvarez, Sofia Perea, Tania Sanchez-Perez, Marta Camacho-Artacho, Francesca Sarno, Victoria Bonilla, Yolanda Durán, Natalia Baños, Maria I. Albarran, Álvaro Otero, Estela Vega, Jorge Monsech, Tirso Pons, Maria Mitsi, Elena Garralda, Rodrigo A. Toledo
Table S2: Custom primers and probes designed based on the Thermofisher online design tool for TaqManÃ,® genotyping assay for KDR c.2518C>T (VEGFR2 p.L840L). TaqManÃ,® MGB (minor groove binder) probes incorporate a 5' reporter (VIC or FAM) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::013f234395f6466cf43496443a6d7c1e
https://doi.org/10.1158/1078-0432.22474707
https://doi.org/10.1158/1078-0432.22474707
Autor:
Manuel Hidalgo, Jorge L. Martínez-Torrecuadrada, Orlando Domínguez, Antonio Cubillo, Carmen Blanco-Aparicio, Daniel Lietha, Alba De Martino, Rafael Álvarez, Sofia Perea, Tania Sanchez-Perez, Marta Camacho-Artacho, Francesca Sarno, Victoria Bonilla, Yolanda Durán, Natalia Baños, Maria I. Albarran, Álvaro Otero, Estela Vega, Jorge Monsech, Tirso Pons, Maria Mitsi, Elena Garralda, Rodrigo A. Toledo
Detailed methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7665c3e5a4f0895b2097985fcf925e74
https://doi.org/10.1158/1078-0432.22474716.v1
https://doi.org/10.1158/1078-0432.22474716.v1
Autor:
Manuel Hidalgo, Jorge L. Martínez-Torrecuadrada, Orlando Domínguez, Antonio Cubillo, Carmen Blanco-Aparicio, Daniel Lietha, Alba De Martino, Rafael Álvarez, Sofia Perea, Tania Sanchez-Perez, Marta Camacho-Artacho, Francesca Sarno, Victoria Bonilla, Yolanda Durán, Natalia Baños, Maria I. Albarran, Álvaro Otero, Estela Vega, Jorge Monsech, Tirso Pons, Maria Mitsi, Elena Garralda, Rodrigo A. Toledo
Figure S4: A) Molecular dynamics simulations with L840F VEGFR2 indicates that most of the adopted F840 conformations during the simulation are not compatible with inhibitor binding. Clashes between VEGFR2 and the sorafenib area are shown as red discs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5914217f21d2d9bb3f0e0e0c3dd085e3
https://doi.org/10.1158/1078-0432.22474728.v1
https://doi.org/10.1158/1078-0432.22474728.v1
Autor:
Manuel Hidalgo, Jorge L. Martínez-Torrecuadrada, Orlando Domínguez, Antonio Cubillo, Carmen Blanco-Aparicio, Daniel Lietha, Alba De Martino, Rafael Álvarez, Sofia Perea, Tania Sanchez-Perez, Marta Camacho-Artacho, Francesca Sarno, Victoria Bonilla, Yolanda Durán, Natalia Baños, Maria I. Albarran, Álvaro Otero, Estela Vega, Jorge Monsech, Tirso Pons, Maria Mitsi, Elena Garralda, Rodrigo A. Toledo
Figure S3: Analyses of interactions between tyrosine kinase receptors and kinase inhibitors, performed with LigProt.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d6777c7b5b228876d1d013a40baee32
https://doi.org/10.1158/1078-0432.22474731.v1
https://doi.org/10.1158/1078-0432.22474731.v1
Autor:
Manuel Hidalgo, Jorge L. Martínez-Torrecuadrada, Orlando Domínguez, Antonio Cubillo, Carmen Blanco-Aparicio, Daniel Lietha, Alba De Martino, Rafael Álvarez, Sofia Perea, Tania Sanchez-Perez, Marta Camacho-Artacho, Francesca Sarno, Victoria Bonilla, Yolanda Durán, Natalia Baños, Maria I. Albarran, Álvaro Otero, Estela Vega, Jorge Monsech, Tirso Pons, Maria Mitsi, Elena Garralda, Rodrigo A. Toledo
Figure S5: A) Levels of phosphorylated ERK following treatment of the MDST8 colorectal cell line, expressing R1032Q VEGFR2, with different kinase inhibitors in the presence. B) Proliferation assays of Colo320 cell lines, stably expressing WT and R103
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04e9345eccf5f5d0fd92b86da13b302d
https://doi.org/10.1158/1078-0432.22474725.v1
https://doi.org/10.1158/1078-0432.22474725.v1
Autor:
Manuel Hidalgo, Jorge L. Martínez-Torrecuadrada, Orlando Domínguez, Antonio Cubillo, Carmen Blanco-Aparicio, Daniel Lietha, Alba De Martino, Rafael Álvarez, Sofia Perea, Tania Sanchez-Perez, Marta Camacho-Artacho, Francesca Sarno, Victoria Bonilla, Yolanda Durán, Natalia Baños, Maria I. Albarran, Álvaro Otero, Estela Vega, Jorge Monsech, Tirso Pons, Maria Mitsi, Elena Garralda, Rodrigo A. Toledo
Figure S6: Assessment of the expression of phosphorylated ERK (p-ERK) in the WT and L840F VEGFR2 PDX Avatar models by immunohistochemistry (A), confocal microscopy (B), and immunoblotting (C). The MAPK pathway was activated in the L840F VEGFR2 mutant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::811f4782046bc0c677e716e77d283559
https://doi.org/10.1158/1078-0432.22474722
https://doi.org/10.1158/1078-0432.22474722