Gout-associated SNP at the IL1RN-IL1F10 region is associated with altered cytokine production in PBMCs of patients with gout and controls

Autor: Orsolya I. Gaal, Megan Leask, Valentin Nica, Georgiana Cabău, Medeea Badii, Ioana Hotea, Dennis M de Graaf, Zhenhua Zhang, Yang Li, Cristina Pamfil, Simona Rednic, Tony R. Merriman, Tania O. Crișan, Leo A.B. Joosten

Publikováno v: Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-12 (2024)

Abstract Objectives Gout is caused by the response of the innate immune system to monosodium urate (MSU) crystals. A recent gout GWAS identified a signal of genetic association at a locus encompassing IL1RN-IL1F10. Colocalisation analysis using Genot

Externí odkaz: https://doaj.org/article/709b73e3a2bf48f4958e8f92a4197842

A functional genomics approach reveals suggestive quantitative trait loci associated with combined TLR4 and BCP crystal-induced inflammation and osteoarthritis

Autor: Viola Klück, Collins K. Boahen, Brenda Kischkel, Jéssica C. Dos Santos, Vasiliki Matzaraki, Cindy G. Boer, Joyce B.J. van Meurs, Kiki Schraa, Heidi Lemmers, Helga Dijkstra, Megan P. Leask, Tony R. Merriman, Tania O. Crişan, Geraldine M. McCarthy, Vinod Kumar, Leo A.B. Joosten

Publikováno v: Osteoarthritis and Cartilage.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a309403b5b4f19684759dec3433a4212
https://doi.org/10.1016/j.joca.2023.04.011

Detection of Novel Biomarkers in Pediatric Autoimmune Hepatitis by Proteomic Profiling

Autor: Claudia Sîrbe, Medeea Badii, Tania O. Crişan, Gabriel Bența, Alina Grama, Leo A. B. Joosten, Simona Rednic, Tudor Lucian Pop

Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 8; Pages: 7479
International Journal of Molecular Sciences, 24
International Journal of Molecular Sciences, 24, 8

Contains fulltext : 292333.pdf (Publisher’s version ) (Open Access) Autoimmune hepatitis (AIH) is characterized by immune-mediated hepatocyte injury resulting in the destruction of liver cells, causing inflammation, liver failure, and fibrosis. Ped

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d08dec31c152456b1d081c55fca688e1
https://doi.org/10.3390/ijms24087479

GWAS-identified hyperuricemia-associated IGF1R variant rs6598541 has a limited role in urate mediated inflammation in human mononuclear cells

Autor: Orsolya I. Gaal, Ruiqi Liu, Dragoș Marginean, Medeea Badii, Georgiana Cabău, Ioana Hotea, Valentin Nica, Doina Colcear, HINT Consortium, Cristina Pamfil, Tony R. Merriman, Simona Rednic, Radu A. Popp, Tania O. Crișan, Leo A. B. Joosten

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)

Abstract Gout is a common autoinflammatory joint diseases characterized by deposition of monosodium urate (MSU) crystals which trigger an innate immune response mediated by inflammatory cytokines. IGF1R is one of the loci associated with both urate l

Externí odkaz: https://doaj.org/article/972891c7991a4a1988a93549186a985c

Romidepsin suppresses monosodium urate crystal-induced cytokine production through upregulation of suppressor of cytokine signaling 1 expression

Autor: Charles A. Dinarello, Romana T. Netea-Maier, Maartje C. P. Cleophas, Leo A. B. Joosten, Mihai G. Netea, Nicoline Hoogerbrugge, Tania O Crişan, Viola Klück

Publikováno v: Arthritis Research & Therapy, 21
Arthritis Research & Therapy
Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-11 (2019)

Background Acute gouty arthritis currently is the most common form of inflammatory arthritis in developed countries. Treatment is still suboptimal. Dosage of urate-lowering therapy is often too low to reach target urate levels, and adherence to thera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::779c1d5fb9209190c56723802afbb13a
https://hdl.handle.net/2066/202134