The Novel Oral BET-CBP/p300 Dual Inhibitor NEO2734 Is Highly Effective in Eradicating Acute Myeloid Leukemia Blasts and Stem/Progenitor Cells

Autor: Noortje van Gils, Tania Martiañez Canales, Eline Vermue, Arjo Rutten, Fedor Denkers, Tiem van der Deure, Gert J. Ossenkoppele, Francis Giles, Linda Smit

Publikováno v: HemaSphere, Vol 5, Iss 8, p e610 (2021)

Acute myeloid leukemia (AML) is a disease characterized by transcriptional dysregulation that results in a block in differentiation and aberrant self-renewal. Inhibitors directed to epigenetic modifiers, aiming at transcriptional reprogramming of AML

Externí odkaz: https://doaj.org/article/3fb817b7e6284c9b96430bb8fba91701

Guidance of Drosophila Mushroom Body Axons Depends upon DRL-Wnt Receptor Cleavage in the Brain Dorsomedial Lineage Precursors

Autor: Elodie Reynaud, Liza L. Lahaye, Ana Boulanger, Iveta M. Petrova, Claire Marquilly, Adrien Flandre, Tania Martianez, Martin Privat, Jasprina N. Noordermeer, Lee G. Fradkin, Jean-Maurice Dura

Publikováno v: Cell Reports, Vol 11, Iss 8, Pp 1293-1304 (2015)

In vivo axon pathfinding mechanisms in the neuron-dense brain remain relatively poorly characterized. We study the Drosophila mushroom body (MB) axons, whose α and β branches connect to different brain areas. We show that the Ryk family WNT5 recept

Externí odkaz: https://doaj.org/article/200f617be84d40088ed02af0586f1252

IGFBP7 Induces Differentiation and Loss of Survival of Human Acute Myeloid Leukemia Stem Cells without Affecting Normal Hematopoiesis

Autor: Meyram Cil, Louise L.E. de Vos Klootwijk, David C. de Leeuw, Eline Vermue, Renee X. de Menezes, Tania Martianez, Marjon A. Smit, Sonja Zweegman, Gerrit Jan Schuurhuis, Arjo Rutten, Noortje van Gils, Mei-Ling Tsui, Linda Smit, Han J.M.P. Verhagen, Jeroen Janssen, Gert J. Ossenkoppele, Stan Heukelom, Fedor Denkers, Anna van Rhenen, Margaretha G.M. Roemer

Publikováno v: Cell Reports, 25(11), 3021-3035.e5. Cell Press
Verhagen, H J M P, van Gils, N, Martiañez, T, van Rhenen, A, Rutten, A, Denkers, F, de Leeuw, D C, Smit, M A, Tsui, M-L, de Vos Klootwijk, L L E, Menezes, R X, Çil, M, Roemer, M G M, Vermue, E, Heukelom, S, Zweegman, S, Janssen, J J W M, Ossenkoppele, G J, Schuurhuis, G J & Smit, L 2018, ' IGFBP7 Induces Differentiation and Loss of Survival of Human Acute Myeloid Leukemia Stem Cells without Affecting Normal Hematopoiesis ', Cell Reports, vol. 25, no. 11, pp. 3021-3035.e5 . https://doi.org/10.1016/j.celrep.2018.11.062
Cell Reports, Vol 25, Iss 11, Pp 3021-3035.e5 (2018)

Summary: Leukemic stem cells (LSCs) are thought to be the major cause of the recurrence of acute myeloid leukemia (AML) due to their potential for self-renewal. To identify therapeutic strategies targeting LSCs, while sparing healthy hematopoietic st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b8d3ddf3c304f3bc7a7e9b1d0e63a3e
https://doi.org/10.1016/j.celrep.2018.11.062

Guidance of Drosophila Mushroom Body Axons Depends upon DRL-Wnt Receptor Cleavage in the Brain Dorsomedial Lineage Precursors

Autor: Iveta M. Petrova, Jean-Maurice Dura, Elodie Reynaud, Claire Marquilly, Martin Privat, Jasprina N. Noordermeer, Liza L. Lahaye, Ana Boulanger, Lee G. Fradkin, Tania Martianez, Adrien Flandre

Publikováno v: Cell Reports
Cell Reports, Elsevier Inc, 2015, 11 (8), pp.1293-1304. ⟨10.1016/j.celrep.2015.04.035⟩
Cell Reports, Vol 11, Iss 8, Pp 1293-1304 (2015)

Summary In vivo axon pathfinding mechanisms in the neuron-dense brain remain relatively poorly characterized. We study the Drosophila mushroom body (MB) axons, whose α and β branches connect to different brain areas. We show that the Ryk family WNT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1be69d5a7ba49cc91aa9657e8e85245
https://hal.archives-ouvertes.fr/hal-01159650/document

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