Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Tania L. Mead"'
Autor:
Tania L. Mead, David C. Harrison, Ian C B Marshall, Ishrut Hussain, K. Brackenborough, Sharlin Ahmed, Julie Hawkins, S.D. Skaper, Ged M.P. Giblin, Trevor Chapman, Adrian Hall, Jill C. Richardson, Maria I. Gonzalez, Beverley Smith, L. Facci
Publikováno v:
Neurodegenerative Diseases. 8:15-24
Background: Cleavage of the amyloid precursor protein (APP) by β-site APP-cleaving enzyme and γ-secretase results in the generation of amyloid-β (Aβ) peptides that aggregate and deposit as senile plaques in brains of Alzheimer disease patients. D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::453bce4124903771ff11c5d368bf1fbf
https://doi.org/10.1159/000313903
https://doi.org/10.1159/000313903
Autor:
Tania L. Mead, Peter Henry Milner, Leann P. Quinn, Nigel Deeks, Giancarlo Trani, Brenda K. Trail, Michael A. Briggs, Christopher N. Johnson, Andrew D. Medhurst, Alison M. Ray, Abir A. Khazragi, Tania O. Stean, David R. Witty, Stuart M. Baddeley, Geoffrey Stemp, Rivers Dean Andrew, Tsu T. Chuang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:5698-5700
Starting from a benzazepine sulfonamide 5-HT(6) receptor antagonist lead with limited brain penetration, application of a strategy of conformational constraint and reduction of hydrogen bond donor count led to a novel series of tricyclic derivatives
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37fdec6da30eb144f3f300af260903a1
https://doi.org/10.1016/j.bmcl.2008.08.010
https://doi.org/10.1016/j.bmcl.2008.08.010
Autor:
Ijeoma F. Uchegbu, Michael S Briggs, Matthew R. Hicks, Tina Daviter, Jamshed Anwar, Mariarosa Mazza, Dave McCarthy, Alison Rodger, Julian Moger, Gary N. Parkinson, Natalie L. Garrett, Tania L. Mead, Rebecca Notman, Andreas G. Schätzlein
Publikováno v:
ACS nano. 7(2)
The delivery of therapeutic peptides and proteins to the central nervous system is the biggest challenge when developing effective neuropharmaceuticals. The central issue is that the blood-brain barrier is impermeable to most molecules. Here we demon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67cbf598fda48980c091cfab9305a1fd
https://pubmed.ncbi.nlm.nih.gov/23289352
https://pubmed.ncbi.nlm.nih.gov/23289352
Autor:
Adrian Hall, David C. Harrison, Robert P. Davis, Ged M.P. Giblin, Andrew D. Medhurst, Jill C. Richardson, Ian C B Marshall, Tania L. Mead, Trevor Chapman, Ishrut Hussain, Sharlin Ahmed, Maria I. Gonzalez, Beverley Smith, Julie Hawkins
Publikováno v:
Neuro-degenerative diseases. 8(6)
Background:Allosteric modulation of γ-secretase is an attractive therapeutic approach for the treatment of Alzheimer’s disease. We recently identified a novel γ-secretase modulator, GSM-10h, which effectively lowers Aβ42 production in cells and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad5e36f060df04693654dae5ed049662
https://pubmed.ncbi.nlm.nih.gov/21389687
https://pubmed.ncbi.nlm.nih.gov/21389687
Autor:
Ishrut, Hussain, David C, Harrison, Julie, Hawkins, Trevor, Chapman, Ian, Marshall, Laura, Facci, Sharlin, Ahmed, Kim, Brackenborough, Stephen D, Skaper, Tania L, Mead, Beverley B, Smith, Gerard M P, Giblin, Adrian, Hall, M Isabel, Gonzalez, Jill C, Richardson
Publikováno v:
Neuro-degenerative diseases. 8(1-2)
Cleavage of the amyloid precursor protein (APP) by β-site APP-cleaving enzyme and γ-secretase results in the generation of amyloid-β (Aβ) peptides that aggregate and deposit as senile plaques in brains of Alzheimer disease patients. Due to the fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::97b3e611a62464ca3d4628bfd50aa38e
https://pubmed.ncbi.nlm.nih.gov/20689247
https://pubmed.ncbi.nlm.nih.gov/20689247