Conjugate Addition of Grignard Reagents to Thiochromones Catalyzed by Copper Salts: A Unified Approach to Both 2-Alkylthiochroman-4-One and Thioflavanone

Autor: Tania J. Bellinger, Teavian Harvin, Ti’Bran Pickens-Flynn, Nataleigh Austin, Samuel H. Whitaker, Mai Ling C. Tang Yuk Tutein, Dabria T. Hukins, Nichele Deese, Fenghai Guo

Publikováno v: Molecules, Vol 25, Iss 9, p 2128 (2020)

Grignard reagents undergo conjugate addition to thiochromones catalyzed by copper salts to afford 2-substituted-thiochroman-4-ones, both 2-alkylthiochroman-4-ones and thioflavanones (2-arylthiochroman-4-ones), in good yields with trimethylsilyl chlor

Externí odkaz: https://doaj.org/article/3e00af3171874e4ba797dcc858740b37

Abstinence-Dependent Effects of Long-Access Cocaine Self-Administration on Nucleus Accumbens Astrocytes Are Observed in Male, But Not Female, Rats

Autor: Ronald Kim, Anze Testen, Eden V. Harder, Natalie E. Brown, Emily A. Witt, Tania J. Bellinger, Janay P. Franklin, Kathryn J. Reissner

Publikováno v: eNeuro. 9(5)

Accumulating evidence indicates significant consequences for astrocytes associated with drug abuse. For example, reductions in structural features and synaptic colocalization of male rat nucleus accumbens (NAc) astrocytes are observed following short

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::524904786a322280450857bd0d0e6145
https://pubmed.ncbi.nlm.nih.gov/35995558

Development of Conjugate Addition of Lithium Dialkylcuprates to Thiochromones: Synthesis of 2-Alkylthiochroman-4-ones and Additional Synthetic Applications

Autor: Dynasty M. Parker, Angelica S. Dibble, Aireal S. Eaton, Kaata L. Koroma, Sylvia A. Sekyi, Fenghai Guo, David A. Pollard, Shekinah A. Bass, Tania J. Bellinger

Publikováno v: Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules, Vol 23, Iss 7, p 1728 (2018)
Molecules
Volume 23
Issue 7

Lithium dialkylcuprates undergo conjugate addition to thiochromones to afford 2-alkylthiochroman-4-ones in good yields. This approach provide an efficient and general synthetic approach to privileged sulfur-containing structural motifs and valuable p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::744b8386da36aa119556526abfbec58b
http://europepmc.org/articles/PMC6099951