Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Tania F de Koning-Ward"'
Autor:
Madeline G Dans, Henni Piirainen, William Nguyen, Sachin Khurana, Somya Mehra, Zahra Razook, Niall D Geoghegan, Aurelie T Dawson, Sujaan Das, Molly Parkyn Schneider, Thorey K Jonsdottir, Mikha Gabriela, Maria R Gancheva, Christopher J Tonkin, Vanessa Mollard, Christopher Dean Goodman, Geoffrey I McFadden, Danny W Wilson, Kelly L Rogers, Alyssa E Barry, Brendan S Crabb, Tania F de Koning-Ward, Brad E Sleebs, Inari Kursula, Paul R Gilson
Publikováno v:
PLoS Biology, Vol 21, Iss 4, p e3002066 (2023)
With emerging resistance to frontline treatments, it is vital that new antimalarial drugs are identified to target Plasmodium falciparum. We have recently described a compound, MMV020291, as a specific inhibitor of red blood cell (RBC) invasion, and
Externí odkaz:
https://doaj.org/article/d4ae40a3c3394669ac6efd4a149b5ec0
Autor:
Rebecca CS Edgar, Ghizal Siddiqui, Katheryn Hjerrild, Tess R Malcolm, Natalie B Vinh, Chaille T Webb, Clare Holmes, Christopher A MacRaild, Hope C Chernih, Willy W Suen, Natalie A Counihan, Darren J Creek, Peter J Scammells, Sheena McGowan, Tania F de Koning-Ward
Publikováno v:
eLife, Vol 11 (2022)
Plasmodium falciparum, the causative agent of malaria, remains a global health threat as parasites continue to develop resistance to antimalarial drugs used throughout the world. Accordingly, drugs with novel modes of action are desperately required
Externí odkaz:
https://doaj.org/article/0679868db9304f46bdc0d01432a2d431
Autor:
Mikha Gabriela, Kathryn M Matthews, Cas Boshoven, Betty Kouskousis, Thorey K Jonsdottir, Hayley E Bullen, Joyanta Modak, David L Steer, Brad E Sleebs, Brendan S Crabb, Tania F de Koning-Ward, Paul R Gilson
Publikováno v:
PLoS Pathogens, Vol 18, Iss 2, p e1009977 (2022)
Plasmodium falciparum exports ~10% of its proteome into its host erythrocyte to modify the host cell's physiology. The Plasmodium export element (PEXEL) motif contained within the N-terminus of most exported proteins directs the trafficking of those
Externí odkaz:
https://doaj.org/article/255e629500da4e7bab4f1622c9b59485
Autor:
Sreejoyee Ghosh, Scott A Chisholm, Madeline Dans, Asha Lakkavaram, Kit Kennedy, Stuart A Ralph, Natalie A Counihan, Tania F de Koning-Ward
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0193538 (2018)
The ability of Plasmodium parasites to egress from their host red blood cell is critical for the amplification of these parasites in the blood. Previous forward chemical genetic approaches have implicated the subtilisin-like protease (SUB1) and the c
Externí odkaz:
https://doaj.org/article/fe4e9dc4fac34c4ea30a511940745b33
Autor:
Natalie A Counihan, Scott A Chisholm, Hayley E Bullen, Anubhav Srivastava, Paul R Sanders, Thorey K Jonsdottir, Greta E Weiss, Sreejoyee Ghosh, Brendan S Crabb, Darren J Creek, Paul R Gilson, Tania F de Koning-Ward
Publikováno v:
eLife, Vol 6 (2017)
Plasmodium falciparum parasites, the causative agents of malaria, modify their host erythrocyte to render them permeable to supplementary nutrient uptake from the plasma and for removal of toxic waste. Here we investigate the contribution of the rhop
Externí odkaz:
https://doaj.org/article/97ed3bf0078b4d8eba8c42a7a6284862
Autor:
Madeline G. Dans, Coralie Boulet, Gabrielle M. Watson, William Nguyen, Jerzy M. Dziekan, Cindy Evelyn, Kitsanapong Reaksudsan, Somya Mehra, Zahra Razook, Niall D. Geoghegan, Michael J. Mlodzianoski, Christopher Dean Goodman, Dawson B. Ling, Thorey K. Jonsdottir, Joshua Tong, Mufuliat Toyin Famodimu, Mojca Kristan, Harry Pollard, Lindsay B. Stewart, Luke Brandner-Garrod, Colin J. Sutherland, Michael J. Delves, Geoffrey I. McFadden, Alyssa E. Barry, Brendan S. Crabb, Tania F. de Koning-Ward, Kelly L. Rogers, Alan F. Cowman, Wai-Hong Tham, Brad E. Sleebs, Paul R. Gilson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract With resistance to most antimalarials increasing, it is imperative that new drugs are developed. We previously identified an aryl acetamide compound, MMV006833 (M-833), that inhibited the ring-stage development of newly invaded merozoites. H
Externí odkaz:
https://doaj.org/article/ff89181888414cdebed058704ff392b1
Autor:
Scott A Chisholm, Emma McHugh, Rachel Lundie, Matthew W A Dixon, Sreejoyee Ghosh, Meredith O'Keefe, Leann Tilley, Ming Kalanon, Tania F de Koning-Ward
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0149296 (2016)
Pathogenesis of malaria infections is linked to remodeling of erythrocytes, a process dependent on the trafficking of hundreds of parasite-derived proteins into the host erythrocyte. Recent studies have demonstrated that the Plasmodium translocon of
Externí odkaz:
https://doaj.org/article/e6bb378e44ec4e6ebf2584b792d91a16
Autor:
Rebecca C. S. Edgar, Tess R. Malcolm, Ghizal Siddiqui, Carlo Giannangelo, Natalie A. Counihan, Matthew Challis, Sandra Duffy, Mrittika Chowdhury, Jutta Marfurt, Madeline Dans, Grennady Wirjanata, Rintis Noviyanti, Kajal Daware, Chathura D. Suraweera, Ric N. Price, Sergio Wittlin, Vicky M. Avery, Nyssa Drinkwater, Susan A. Charman, Darren J. Creek, Tania F. de Koning-Ward, Peter J. Scammells, Sheena McGowan
Publikováno v:
mBio, Vol 15, Iss 6 (2024)
ABSTRACT To combat the global burden of malaria, development of new drugs to replace or complement current therapies is urgently required. Here, we show that the compound MMV1557817 is a selective, nanomolar inhibitor of both Plasmodium falciparum an
Externí odkaz:
https://doaj.org/article/2d940180a1bd41efa98e153bebf7c041
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61482 (2013)
Protein export into the host red blood cell is one of the key processes in the pathobiology of the malaria parasite Plasmodiumtrl falciparum, which extensively remodels the red blood cell to ensure its virulence and survival. In this study, we aimed
Externí odkaz:
https://doaj.org/article/ace7961a0d8e4116a2967c3172c4d494
Autor:
Madeline G. Dans, Coralie Boulet, Gabrielle M. Watson, William Nguyen, Jerzy M. Dziekan, Cindy Evelyn, Kitsanapong Reaksudsan, Somya Mehra, Zahra Razook, Niall D. Geoghegan, Michael J. Mlodzianoski, Christopher Dean Goodman, Dawson B. Ling, Thorey K. Jonsdottir, Joshua Tong, Mufuliat Toyin Famodimu, Mojca Kristan, Harry Pollard, Lindsay B. Stewart, Luke Brandner-Garrod, Colin J. Sutherland, Michael J. Delves, Geoffrey I. McFadden, Alyssa E. Barry, Brendan S. Crabb, Tania F. de Koning-Ward, Kelly L. Rogers, Alan F. Cowman, Wai-Hong Tham, Brad E. Sleebs, Paul R. Gilson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/36bf3afec36e4aac961dcc7fb75d1e5e