Zobrazeno 1 - 10
of 148
pro vyhledávání: '"Tania F, Gendron"'
Autor:
Anna Calliari, Lillian M. Daughrity, Ellen A. Albagli, Paula Castellanos Otero, Mei Yue, Karen Jansen-West, Naeyma N. Islam, Thomas Caulfield, Bailey Rawlinson, Michael DeTure, Casey Cook, Neill R. Graff-Radford, Gregory S. Day, Bradley F. Boeve, David S. Knopman, Ronald C. Petersen, Keith A. Josephs, Björn Oskarsson, Aaron D. Gitler, Dennis W. Dickson, Tania F. Gendron, Mercedes Prudencio, Michael E. Ward, Yong-Jie Zhang, Leonard Petrucelli
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-5 (2024)
Abstract This letter demonstrates the potential of novel cryptic proteins resulting from TAR DNA-binding protein 43 (TDP-43) dysfunction as markers of TDP-43 pathology in neurodegenerative diseases.
Externí odkaz:
https://doaj.org/article/a36e0957494842178bf60c68ee7aa96b
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-18 (2024)
Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the loss of upper and lower motor neurons. Presently, three FDA-approved drugs are available to help slow functional decline for patients with ALS, but
Externí odkaz:
https://doaj.org/article/518a7a5645914b05bd79656c6e8888eb
Autor:
Anna Calliari, Lillian M. Daughrity, Ellen A. Albagli, Paula Castellanos Otero, Mei Yue, Karen Jansen-West, Naeyma N. Islam, Thomas Caulfield, Bailey Rawlinson, Michael DeTure, Casey Cook, Neill R. Graff-Radford, Gregory S. Day, Bradley F. Boeve, David S. Knopman, Ronald C. Petersen, Keith A. Josephs, Björn Oskarsson, Aaron D. Gitler, Dennis W. Dickson, Tania F. Gendron, Mercedes Prudencio, Michael E. Ward, Yong-Jie Zhang, Leonard Petrucelli
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-2 (2024)
Externí odkaz:
https://doaj.org/article/9628565cd0fc43dc81e3535e124ec483
Neurofilament light chain and vaccination status associate with clinical outcomes in severe COVID-19
Autor:
Young Erben, Mercedes Prudencio, Christopher P. Marquez, Karen R. Jansen-West, Michael G. Heckman, Launia J. White, Judith A. Dunmore, Casey N. Cook, Meredith T. Lilley, Neda Qosja, Yuping Song, Rana Hanna Al Shaikh, Lillian M. Daughrity, Jordan L. Bartfield, Gregory S. Day, Björn Oskarsson, Katharine A. Nicholson, Zbigniew K. Wszolek, Jonathan B. Hoyne, Tania F. Gendron, James F. Meschia, Leonard Petrucelli
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109501- (2024)
Externí odkaz:
https://doaj.org/article/515102c98dc744f898e79fd9517e485b
Autor:
Rita Sattler, Bryan J. Traynor, Janice Robertson, Ludo Van Den Bosch, Sami J. Barmada, Clive N. Svendsen, Matthew D. Disney, Tania F. Gendron, Philip C. Wong, Martin R. Turner, Adam Boxer, Suma Babu, Michael Benatar, Michael Kurnellas, Jonathan D. Rohrer, Christopher J. Donnelly, Lynette M. Bustos, Kendall Van Keuren-Jensen, Penny A. Dacks, Marwan N. Sabbagh, Attendees of the inaugural C9ORF72 FTD/ALS Summit
Publikováno v:
Neurology and Therapy, Vol 12, Iss 6, Pp 1821-1843 (2023)
Abstract A summit held March 2023 in Scottsdale, Arizona (USA) focused on the intronic hexanucleotide expansion in the C9ORF72 gene and its relevance in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS; C9ORF72-FTD/ALS). The goal
Externí odkaz:
https://doaj.org/article/29cedee3ed35403a952639263a5b1ede
Autor:
Henrick Riemenschneider, Francesca Simonetti, Udit Sheth, Eszter Katona, Stefan Roth, Saskia Hutten, Daniel Farny, Meike Michaelsen, Brigitte Nuscher, Michael K. Schmidt, Andrew Flatley, Aloys Schepers, Lara A. Gruijs da Silva, Qihui Zhou, Thomas Klopstock, Arthur Liesz, Thomas Arzberger, Jochen Herms, Regina Feederle, Tania F. Gendron, Dorothee Dormann, Dieter Edbauer
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-26 (2023)
Abstract Cytoplasmic aggregation and concomitant nuclear clearance of the RNA-binding protein TDP-43 are found in ~ 90% of cases of amyotrophic lateral sclerosis and ~ 45% of patients living with frontotemporal lobar degeneration, but no disease-modi
Externí odkaz:
https://doaj.org/article/d7d0c5c3d184474fbef7b702542a9df6
Autor:
Paula Castellanos Otero, Tiffany W Todd, Wei Shao, Caroline J Jones, Kexin Huang, Lillian M Daughrity, Mei Yue, Udit Sheth, Tania F Gendron, Mercedes Prudencio, Björn Oskarsson, Dennis W Dickson, Leonard Petrucelli, Yong-Jie Zhang
Publikováno v:
PLoS ONE, Vol 19, Iss 4, p e0298080 (2024)
Inclusions containing TAR DNA binding protein 43 (TDP-43) are a pathological hallmark of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). One of the disease-specific features of TDP-43 inclusions is the aberrant phosphorylation
Externí odkaz:
https://doaj.org/article/8a84232f980c4c2ab3c974b7c2363957
Autor:
Jinyoung Park, Yanwei Wu, Wei Shao, Tania F. Gendron, Sophie J.F. van der Spek, Grigorii Sultanakhmetov, Avik Basu, Paula Castellanos Otero, Caroline J. Jones, Karen Jansen-West, Lillian M. Daughrity, Sadhna Phanse, Giulia del Rosso, Jimei Tong, Monica Castanedes-Casey, Lulu Jiang, Jenna Libera, Björn Oskarsson, Dennis W. Dickson, David W. Sanders, Clifford P. Brangwynne, Andrew Emili, Benjamin Wolozin, Leonard Petrucelli, Yong-Jie Zhang
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112822- (2023)
Summary: C9orf72 repeat expansions are the most common genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Poly(GR) proteins are toxic to neurons by forming cytoplasmic inclusions that sequester RNA-binding protein
Externí odkaz:
https://doaj.org/article/b8020317518447719952eee97c008bca
Autor:
Katharina E. Meijboom, Abbas Abdallah, Nicholas P. Fordham, Hiroko Nagase, Tomás Rodriguez, Carolyn Kraus, Tania F. Gendron, Gopinath Krishnan, Rustam Esanov, Nadja S. Andrade, Matthew J. Rybin, Melina Ramic, Zachary D. Stephens, Alireza Edraki, Meghan T. Blackwood, Aydan Kahriman, Nils Henninger, Jean-Pierre A. Kocher, Michael Benatar, Michael H. Brodsky, Leonard Petrucelli, Fen-Biao Gao, Erik J. Sontheimer, Robert H. Brown, Zane Zeier, Christian Mueller
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
A hexanucleotide repeat expansion in C9ORF72 is the most common genetic cause of ALS and FTD. Here, the authors demonstrate CRISPR/Cas9 excision of the expansion results in a rescue of disease mechanisms in vivo and in vitro.
Externí odkaz:
https://doaj.org/article/3c12d94acb99423da250fefe20d4cde2
Autor:
Ileana Lorenzini, Eric Alsop, Jennifer Levy, Lauren M. Gittings, Deepti Lall, Benjamin E. Rabichow, Stephen Moore, Ryan Pevey, Lynette M. Bustos, Camelia Burciu, Divya Bhatia, Mo Singer, Justin Saul, Amanda McQuade, Makis Tzioras, Thomas A. Mota, Amber Logemann, Jamie Rose, Sandra Almeida, Fen-Biao Gao, Michael Marks, Christopher J. Donnelly, Elizabeth Hutchins, Shu-Ting Hung, Justin Ichida, Robert Bowser, Tara Spires-Jones, Mathew Blurton-Jones, Tania F. Gendron, Robert H. Baloh, Kendall Van Keuren-Jensen, Rita Sattler
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
While motor and cortical neurons are affected in C9orf72 amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD), it remains largely unknown if and how non-neuronal cells induce or exacerbate neuronal damage. We differentiated C9orf72 ALS
Externí odkaz:
https://doaj.org/article/c5861f14d9984d6d91846ead3941a04a