Zobrazeno 1 - 7 of 7 pro vyhledávání: '"Tania E. Perez Jimenez"'
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Akademický článek
Pharmacogenomics of poor drug metabolism in greyhounds: Canine P450 oxidoreductase genetic variation, breed heterogeneity, and functional characterization.
Autor: Stephanie E Martinez, Amit V Pandey, Tania E Perez Jimenez, Zhaohui Zhu, Michael H Court
Publikováno v: PLoS ONE, Vol 19, Iss 2, p e0297191 (2024)
Greyhounds metabolize cytochrome P450 (CYP) 2B11 substrates more slowly than other dog breeds. However, CYP2B11 gene variants associated with decreased CYP2B11 expression do not fully explain reduced CYP2B11 activity in this breed. P450 oxidoreductas
Externí odkaz: https://doaj.org/article/e9c2e0fc00bd4d3cb1ae442b2b722a59
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Absolute Quantitation of Drug-Metabolizing Cytochrome P450 Enzymes and Accessory Proteins in Dog Liver Microsomes Using Label-Free Standard-Free Analysis Reveals Interbreed Variability
Autor: Michael H. Court, Jian Shi, Zhaohui Zhu, Stephanie E. Martinez, Tania E. Perez Jimenez, Hao Jie Zhu
Publikováno v: Drug Metab Dispos
Dogs are commonly used in human and veterinary pharmaceutical development. Physiologically based pharmacokinetic modeling using recombinant cytochrome P450 (CYP) enzymes requires accurate estimates of CYP abundance, particularly in liver. However, su
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0dcb19c524908af411613b5e42316ca
https://doi.org/10.1124/dmd.119.088070
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3
Oral Coadministration of Fluconazole with Tramadol Markedly Increases Plasma and Urine Concentrations of Tramadol and the O-Desmethyltramadol Metabolite in Healthy Dogs
Autor: Tamara Grubb, Stephen A. Greene, Katrina L. Mealey, Butch KuKanich, Tania E. Perez Jimenez, Michael H. Court, Hyun Joo
Publikováno v: Drug Metabolism and Disposition. 47:15-25
Tramadol is used frequently in the management of mild to moderate pain conditions in dogs. This use is controversial because multiple reports in treated dogs demonstrate very low plasma concentrations of O-desmethyltramadol (M1), the active metabolit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9230c3b2dc6c69b68478e8f6b854c44
https://doi.org/10.1124/dmd.118.083444
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4
Identification of canine cytochrome P-450s (CYPs) metabolizing the tramadol (+)-M1 and (+)-M2 metabolites to the tramadol (+)-M5 metabolite in dog liver microsomes
Autor: Michael H. Court, Darren R. Schnider, Stephen A. Greene, Tamara Grubb, Katrina L. Mealey, Tania E. Perez Jimenez
We previously showed that (+)-tramadol is metabolized in dog liver to (+)-M1 exclusively by CYP2D15 and to (+)-M2 by multiple CYPs, but primarily CYP2B11. However, (+)-M1 and (+)-M2 are further metabolized in dogs to (+)-M5, which is the major metabo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e549b9945ad00b861b2cc5fa3efeeee8
https://europepmc.org/articles/PMC6214715/
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Tramadol metabolism to O-desmethyl tramadol (M1) and N-desmethyl tramadol (M2) by dog liver microsomes: Species comparison and identification of responsible canine cytochrome P-450s (CYPs)
Autor: Stephen A. Greene, Tamara Grubb, Michael H. Court, Katrina L. Mealey, Tania E. Perez Jimenez
Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 44(12)
Tramadol is widely used to manage mild to moderately painful conditions in dogs. However, this use is controversial, since clinical efficacy studies in dogs showed conflicting results, whereas pharmacokinetic studies demonstrated relatively low circu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86d20d9ebf6c2dbfe5a4b70e90608bc9
https://pubmed.ncbi.nlm.nih.gov/28559373
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