Armc5 deletion causes developmental defects and compromises T-cell immune responses

Autor: Yan Hu, Linjiang Lao, Jianning Mao, Wei Jin, Hongyu Luo, Tania Charpentier, Shijie Qi, Junzheng Peng, Bing Hu, Mieczyslaw Martin Marcinkiewicz, Alain Lamarre, Jiangping Wu

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)

Mutations in ARMC5 are associated with risk of primary macronodular adrenal gland hyperplasia. Here the authors show that mice lacking Armc5 have adrenal gland hyperplasia and defective T-cell proliferation, differentiation, survival andin vivoT-cell

Externí odkaz: https://doaj.org/article/0d311a9e7d404d268f2692096b76319b

IRF-5-Mediated Inflammation Limits CD8+ T Cell Expansion by Inducing HIF-1α and Impairing Dendritic Cell Functions during Leishmania Infection.

Autor: Akil Hammami, Tania Charpentier, Mélina Smans, Simona Stäger

Publikováno v: PLoS Pathogens, Vol 11, Iss 6, p e1004938 (2015)

Inflammation is known to be necessary for promoting, sustaining, and tuning CD8+ T cell responses. Following experimental Leishmania donovani infection, the inflammatory response is mainly induced by the transcription factor IRF-5. IRF-5 is responsib

Externí odkaz: https://doaj.org/article/b1565fc7169b44e9bd94837713852354

Induction of thymic atrophy and loss of thymic output by type-I interferons during chronic viral infection

Autor: Thomas Démoulins, Marie-Laurence Baron, Dominique Gauchat, Nadia Kettaf, Steven James Reed, Tania Charpentier, Ulrich Kalinke, Alain Lamarre, Rafi Ahmed, Rafick-Pierre Sékaly, Surojit Sarkar, Vandana Kalia

Publikováno v: Virology. 567

Type-I interferon (IFN-I) signals exert a critical role in disease progression during viral infections. However, the immunomodulatory mechanisms by which IFN-I dictates disease outcomes remain to be fully defined. Here we report that IFN-I signals me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27c3877209010791b21139ce1d2ea96b
https://pubmed.ncbi.nlm.nih.gov/35032866

eIF4E-Binding Proteins 1 and 2 Limit Macrophage Anti-Inflammatory Responses through Translational Repression of IL-10 and Cyclooxygenase-2

Autor: Léon C van Kempen, Visnu Chaparro, Julie Lorent, Louis-Philippe Leroux, Simona Stäger, Maritza Jaramillo, Tyson E. Graber, Charles M. Dozois, Marie-Noël M’Boutchou, Aymeric Fabié, Tania Charpentier, Mirtha William, Tommy Alain, Ola Larsson

Publikováno v: Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2018, 200 (12), pp.4102-4116. ⟨10.4049/jimmunol.1701670⟩
Journal of Immunology, 200(12), 4102-4116. AMER ASSOC IMMUNOLOGISTS

Macrophages represent one of the first lines of defense during infections and are essential for resolution of inflammation following pathogen clearance. Rapid activation or suppression of protein synthesis via changes in translational efficiency allo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::860ac6151976b26c8cd8c12775223ff4
https://research.rug.nl/en/publications/633d80a8-051e-49ea-9d8a-c1a7a5d38744

IL-2 and IL-15 regulate CD8+memory T-cell differentiation but are dispensable for protective recall responses

Autor: Cedric Mathieu, Tania Charpentier, Sara Bourbonnais, Alain Lamarre, Jean-Christophe Beltra, James P. Di Santo, Hélène Decaluwe

Publikováno v: European Journal of Immunology. 45:3324-3338

The ability to mount effective secondary responses is a cardinal feature of memory CD8(+) T cells. An understanding of the factors that regulate the generation and recall capacities of memory T cells remains to be ascertained. Several cues indicate t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::87357c3967276ed80193d84afee27e78
https://doi.org/10.1002/eji.201546000