DNA methylation levels are associated with CRF1 receptor antagonist treatment outcome in women with post-traumatic stress disorder

Autor: Julius C. Pape, Tania Carrillo-Roa, Barbara O. Rothbaum, Charles B. Nemeroff, Darina Czamara, Anthony S. Zannas, Dan Iosifescu, Sanjay J. Mathew, Thomas C. Neylan, Helen S. Mayberg, Boadie W. Dunlop, Elisabeth B. Binder

Publikováno v: Clinical Epigenetics, Vol 10, Iss 1, Pp 1-11 (2018)

Abstract Background We have previously evaluated the efficacy of the CRF1 receptor antagonist GSK561679 in female PTSD patients. While GSK561679 was not superior to placebo overall, it was associated with a significantly stronger symptom reduction in

Externí odkaz: https://doaj.org/article/1be6c64356324c6199a80ce93fd0d69b

A peripheral epigenetic signature of immune system genes is linked to neocortical thickness and memory

Autor: Virginie Freytag, Tania Carrillo-Roa, Annette Milnik, Philipp G. Sämann, Vanja Vukojevic, David Coynel, Philippe Demougin, Tobias Egli, Leo Gschwind, Frank Jessen, Eva Loos, Wolfgang Maier, Steffi G. Riedel-Heller, Martin Scherer, Christian Vogler, Michael Wagner, Elisabeth B. Binder, Dominique J. -F. de Quervain, Andreas Papassotiropoulos

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)

Cortical thickness has high heritability estimates and is known to be influenced by genetic factors. Here, Freytag and colleagues show that DNA methylation patterns of peripheral blood monocytes are also correlated with cortical thickness and memory

Externí odkaz: https://doaj.org/article/68e0d431fcb64aa2a850d28502bea6c8

Common genes associated with antidepressant response in mouse and man identify key role of glucocorticoid receptor sensitivity.

Autor: Tania Carrillo-Roa, Christiana Labermaier, Peter Weber, David P Herzog, Caleb Lareau, Sara Santarelli, Klaus V Wagner, Monika Rex-Haffner, Daniela Harbich, Sebastian H Scharf, Charles B Nemeroff, Boadie W Dunlop, W Edward Craighead, Helen S Mayberg, Mathias V Schmidt, Manfred Uhr, Florian Holsboer, Inge Sillaber, Elisabeth B Binder, Marianne B Müller

Publikováno v: PLoS Biology, Vol 15, Iss 12, p e2002690 (2017)

Response to antidepressant treatment in major depressive disorder (MDD) cannot be predicted currently, leading to uncertainty in medication selection, increasing costs, and prolonged suffering for many patients. Despite tremendous efforts in identify

Externí odkaz: https://doaj.org/article/74a12f29eea14bc19e0b8a9d718c08d4

Identifying the Common Genetic Basis of Antidepressant Response

Autor: Sara A. Paciga, Richard M. Weinshilboum, Andrew M. McIntosh, Tim B. Bigdeli, Stephanie H. Witt, Sven Cichon, Glyn Lewis, Henning Teismann, Brenda W.J.H. Penninx, Gerome Breen, Roseann E. Peterson, Saira Saeed Mirza, Diego Albani, Lisa Jones, Andreas J. Forstner, Sara Mostafavi, Julien Bryois, Qingqin S. Li, Kenneth S. Kendler, Thomas Damm Als, Fernando S. Goes, Marie Bækvad-Hansen, Nancy L. Pedersen, Gianluigi Forloni, Per Qvist, Carsten Horn, Per Hoffmann, Steven P. Hamilton, Georg Homuth, Michael Gill, Julien Mendlewicz, Katharina Domschke, Volker Arolt, Adrian I. Campos, Christine Søholm Hansen, Scott D. Gordon, Hogni Oskarsson, Peter McGuffin, Oliver Pain, Eric Jorgenson, Victoria S. Marshe, Stacy Steinberg, Bertram Müller-Myhsok, Mark Adams, J. Raymond DePaulo, Rick Jansen, Katherine J. Aitchison, Vassily Trubetskoy, Henry Völzke, Manuel Mattheisen, Bernard Ng, James A. Knowles, Dorret I. Boomsma, Tracy Air, Elisabeth B. Binder, Ian B. Hickie, Christel M. Middeldorp, Tõnu Esko, David M. Hougaard, E.J.C. de Geus, Toni-Kim Clarke, Helena Gaspar, Bernhard T. Baune, Abdel Abdellaoui, Engilbert Sigurdsson, Andres Metspalu, Klaus Berger, Jorge A. Quiroz, Patrick F. Sullivan, Aartjan T.F. Beekman, Thomas Hansen, Panagiotis Ferentinos, Jürgen Wellmann, Miguel E. Rentería, Daniel Umbricht, Marcella Rietschel, Stanley I. Shyn, Chiara Fabbri, Hreinn Stefansson, Jerome C. Foo, Daniel Souery, Zoltán Kutalik, Yu-Li Liu, Paul F. O'Reilly, Michael John Owen, Nese Direk, Douglas F. Levinson, Stuart Montgomery, Hamdi Mbarek, David M. Howard, Guido Bondolfi, Lucía Colodro-Conde, Pippa A. Thomson, Merete Nordentoft, Stefan Kloiber, Yunpeng Wang, Michael Conlon O'Donovan, Grant C.B. Sinnamon, Alexander Viktorin, Hilary K. Finucane, Esben Agerbo, Stefan Herms, Markus M. Nöthen, Till F. M. Andlauer, Divya Mehta, Bradley T. Webb, Joanna M. Biernacka, David J. Porteous, Jordan W. Smoller, Jonathan R. I. Coleman, Dean F. MacKinnon, Farnush Farhadi Hassan Kiadeh, Baptiste Couvy-Duchesne, Evelin Mihailov, Eleanor M. Wigmore, Franziska Degenhardt, Jianxin Shi, Dale R. Nyholt, Enda M. Byrne, Stephan Ripke, Ole Mors, Patrik K. E. Magnusson, Eric J. Lenze, Warren W. Kretzschmar, Masaki Kato, Marcus Ising, Ian Jones, Lynsey S. Hall, Wouter J. Peyrot, Ling Shen, Nader Perroud, Na Cai, Maciej Trzaskowski, Matthias Nauck, Isaac S. Kohane, Enrico Domenici, Fabian Streit, James L. Kennedy, Peter M. Visscher, Valentina Escott-Price, Donald J. MacIntyre, Enrique Castelao, Margarita Rivera, Mojca Z. Dernovsek, John P. Rice, Joseph Zohar, Gail Davies, Andrew C. Heath, Josef Frank, Wesley K. Thompson, Caroline Hayward, Penelope A. Lind, Thorgeir E. Thorgeirsson, Rudolf Uher, Jana Strohmaier, Henriette N. Buttenschøn, Erin C. Dunn, Jonas Bybjerg-Grauholm, Alexander Teumer, Jakob Grove, Eske M. Derks, Nicholas G. Martin, Jodie N. Painter, Myrna M. Weissman, Preben Bo Mortensen, Michel G. Nivard, Catherine Schaefer, Yihan Li, Daniel J. Smith, Shih-Jen Tsai, Niamh Mullins, Jian Yang, Marianne Giørtz Pedersen, Dan Rujescu, Thomas G. Schulze, Lili Milani, Yuri Milaneschi, Giorgio Pistis, James B. Potash, Neven Henigsberg, Nicholas John Craddock, Karen Hodgson, Silviu-Alin Bacanu, Shantel Weinsheimer, Charles F. Reynolds, Johannes H. Smit, Gonneke Willemsen, Futao Zhang, Henning Tiemeier, Grant W. Montgomery, Martin Preisig, Udo Dannlowski, Thalia C. Eley, Thomas Werge, Katherine E. Tansey, Jane H. Christensen, Julia Kraft, Ian J. Deary, Cathryn M. Lewis, Sarah E. Medland, André G. Uitterlinden, Daniel J. Müller, Carsten Bøcker Pedersen, Gustavo Turecki, Hans J. Grabe, Matthew Traylor, Brien P. Riley, Roy H. Perlis, Patrick J. McGrath, Conor V. Dolan, Hualin S. Xi, Jonathan Marchini, Robert A. Schoevers, Albert M. van Hemert, Anders D. Børglum, Susanne Lucae, Jouke-Jan Hottenga, Kari Stefansson, Benoit H. Mulsant, Francis M. Mondimore, Naomi R. Wray, Yang Wu, Wolfgang Maier, Danielle Posthuma, Annamaria Cattaneo, Gregory E. Crawford, Siegfried Kasper, Alessandro Serretti, Tania Carrillo-Roa, Robert Maier, Pamela A. F. Madden, Eva C. Schulte, Jens Treutlein, Joanna Hauser, Sandra Van der Auwera

Publikováno v: GSRD Consortium & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium 2022, ' Identifying the Common Genetic Basis of Antidepressant Response ', Biological Psychiatry Global Open Science, vol. 2, no. 2, pp. 115-126 . https://doi.org/10.1016/j.bpsgos.2021.07.008
Pain, O, Hodgson, K, Trubetskoy, V, Ripke, S, Marshe, V S, Adams, M J, Byrne, E M, Campos, A I, Carrillo-Roa, T, Cattaneo, A, Als, T D, Souery, D, Dernovsek, M Z, Fabbri, C, Hayward, C, Henigsberg, N, Hauser, J, Kennedy, J L, Lenze, E J, Lewis, G, Müller, D J, Martin, N G, Mulsant, B H, Mors, O, Perroud, N, Porteous, D J, Rentería, M E, Reynolds, C F, Rietschel, M, Uher, R, Wigmore, E M, Maier, W, Wray, N R, Aitchison, K J, Arolt, V, Baune, B T, Biernacka, J M, Bondolfi, G, Domschke, K, Kato, M, Li, Q S, Liu, Y-L, Serretti, A, Tsai, S-J, Turecki, G & Weinshilboum, R & McIntosh, A M & Lewis, C M 2022, ' Identifying the Common Genetic Basis of Antidepressant Response ', Biological psychiatry global open science, vol. 2, no. 2, pp. 115-126 . https://doi.org/10.1016/j.bpsgos.2021.07.008
Biological Psychiatry Global Open Science, 2(2), 115-126. Elsevier BV
McIntosh, A M, Lewis, C M, GSRD Consortium & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium 2022, ' Identifying the Common Genetic Basis of Antidepressant Response ', Biological Psychiatry: Global Open Science, vol. 2, no. 2, pp. 115-126 . https://doi.org/10.1016/j.bpsgos.2021.07.008
Biological psychiatry: global open science 2(2), 115-126 (2022). doi:10.1016/j.bpsgos.2021.07.008
Biological Psychiatry Global Open Science, 2(2), 115-126
Biological Psychiatry Global Open Science, 2(2), 115-126. Elsevier

Background: Antidepressants are a first-line treatment for depression. However, only a third of individuals experience remission after the first treatment. Common genetic variation, in part, likely regulates antidepressant response, yet the success o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c907fa773f30e9647559b297edd74e1d
https://pure.au.dk/portal/da/publications/identifying-the-common-genetic-basis-of-antidepressant-response(7255846b-ac58-462b-be46-77e5e1468621).html

Pharmacogenomics‐Driven Prediction of Antidepressant Treatment Outcomes: A Machine‐Learning Approach With Multi‐trial Replication

Autor: Richard M. Weinshilboum, A. John Rush, Michelle K. Skime, Joanna M. Biernacka, Liewei Wang, Ravishankar K. Iyer, Drew Neavin, Elisabeth B. Binder, William V. Bobo, Mark A. Frye, Tania Carrillo-Roa, Arjun P. Athreya

Publikováno v: Clinical Pharmacology and Therapeutics

We set out to determine whether machine learning–based algorithms that included functionally validated pharmacogenomic biomarkers joined with clinical measures could predict selective serotonin reuptake inhibitor (SSRI) remission/response in patien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad2d7142f8d2cc7338775ebef062168d
https://doi.org/10.1002/cpt.1482