Alternative splicing of jnk1a in zebrafish determines first heart field ventricular cardiomyocyte numbers through modulation of hand2 expression.

Autor: Adrian Santos-Ledo, Sam Washer, Tamil Dhanaseelan, Lorraine Eley, Ahlam Alqatani, Paul W Chrystal, Tania Papoutsi, Deborah J Henderson, Bill Chaudhry

Publikováno v: PLoS Genetics, Vol 16, Iss 5, p e1008782 (2020)

The planar cell polarity pathway is required for heart development and whilst the functions of most pathway members are known, the roles of the jnk genes in cardiac morphogenesis remain unknown as mouse mutants exhibit functional redundancy, with ear

Externí odkaz: https://doaj.org/article/63f52ccabfb1416fa57b572b534e0b57

Neural crest cell survival is dependent on Rho kinase and is required for development of the mid face in mouse embryos.

Autor: Helen M Phillips, Tania Papoutsi, Helena Soenen, Patricia Ybot-Gonzalez, Deborah J Henderson, Bill Chaudhry

Publikováno v: PLoS ONE, Vol 7, Iss 5, p e37685 (2012)

Neural crest cells (NCC) give rise to much of the tissue that forms the vertebrate head and face, including cartilage and bone, cranial ganglia and teeth. In this study we show that conditional expression of a dominant-negative (DN) form of Rho kinas

Externí odkaz: https://doaj.org/article/2d40986f34ef450587231f50ca535800

Sequential Ligand-Dependent Notch Signaling Activation Regulates Valve Primordium Formation and Morphogenesis

Autor: Mauro Sbroggiò, Tania Papoutsi, Vanesa Bou, Gaetano D'Amato, Luis Jesús Jiménez-Borreguero, Beatriz Martínez-Poveda, Stanislao Igor Travisano, José Luis de la Pompa, Gonzalo del Monte-Nieto, Juan Miguel Redondo, Donal MacGrogan, Bin Zhou, Pablo Gómez-del Arco, Manuel Gómez, Guillermo Luxán

Publikováno v: Circulation Research. 118:1480-1497

Rationale: The Notch signaling pathway is crucial for primitive cardiac valve formation by epithelial–mesenchymal transition, and NOTCH1 mutations cause bicuspid aortic valve; however, the temporal requirement for the various Notch ligands and rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3582dc2d365ada6ea71dbbaa06e054c
https://doi.org/10.1161/circresaha.115.308077

Bmp2 and Notch cooperate to pattern the embryonic endocardium

Autor: Belén Prados, José Luis de la Pompa, Luis Luna-Zurita, Tania Papoutsi, Stéphane Zaffran

Publikováno v: Development (Cambridge, England)
Development (Cambridge, England), Company of Biologists, 2018, 145 (13), pp.dev163378. ⟨10.1242/dev.163378⟩
Development (Cambridge, England), 2018, 145 (13), pp.dev163378. ⟨10.1242/dev.163378⟩

International audience; Signaling interactions between the myocardium and endocardium pattern embryonic cardiac regions, instructing their development to fulfill specific functions in the mature heart. We show that ectopic Bmp2 expression in the mous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3bb1b1b318babf6e28b5a7b981ec9b6
https://hal.archives-ouvertes.fr/hal-01874794/file/dev163378.full.pdf

Msx1CreERT2 knock-In allele: A useful tool to target embryonic and adult cardiac valves

Autor: Tania, Papoutsi, Gaëlle, Odelin, Thomas, Moore-Morris, Michel, Pucéat, José Luis, de la Pompa, Benoît, Robert, Stéphane, Zaffran

Publikováno v: Genesis (New York, N.Y. : 2000). 53(5)

Heart valve development begins with the endothelial-to-mesenchymal transition (EMT) of endocardial cells. Although lineage studies have demonstrated contributions from cardiac neural crest and epicardium to semilunar and atrioventricular (AV) valve f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3be877954a7f042b193e299dcb8cce2a
https://pubmed.ncbi.nlm.nih.gov/25950518