Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Tania, Pannellini"'
Autor:
Haemin Kim, In Ah Choi, Akio Umemoto, Seyeon Bae, Kaichi Kaneko, Masataka Mizuno, Eugenia Giannopoulou, Tania Pannellini, Liang Deng, Kyung-Hyun Park-Min
Publikováno v:
Bone Research, Vol 12, Iss 1, Pp 1-15 (2024)
Abstract Osteoclasts are multinucleated bone-resorbing cells, and their formation is tightly regulated to prevent excessive bone loss. However, the mechanisms by which osteoclast formation is restricted remain incompletely determined. Here, we found
Externí odkaz:
https://doaj.org/article/5eab2e5afb7f4e7eaba7faad73e127a2
Autor:
Hubert Pakula, Mohamed Omar, Ryan Carelli, Filippo Pederzoli, Giuseppe Nicolò Fanelli, Tania Pannellini, Fabio Socciarelli, Lucie Van Emmenis, Silvia Rodrigues, Caroline Fidalgo-Ribeiro, Pier Vitale Nuzzo, Nicholas J. Brady, Wikum Dinalankara, Madhavi Jere, Itzel Valencia, Christopher Saladino, Jason Stone, Caitlin Unkenholz, Richard Garner, Mohammad K. Alexanderani, Francesca Khani, Francisca Nunes de Almeida, Cory Abate-Shen, Matthew B. Greenblatt, David S. Rickman, Christopher E. Barbieri, Brian D. Robinson, Luigi Marchionni, Massimo Loda
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract In the complex tumor microenvironment (TME), mesenchymal cells are key players, yet their specific roles in prostate cancer (PCa) progression remain to be fully deciphered. This study employs single-cell RNA sequencing to delineate molecular
Externí odkaz:
https://doaj.org/article/f358a6f85a6c4b2189686dbb0cfa358f
Autor:
Ayana E Morales, Ruby Gumenick, Caitlyn M Genovese, Yun Yeong Jang, Ariene Ouedraogo, Maite Ibáñez de Garayo, Tania Pannellini, Sanjay Patel, Matthew E Bott, Julio Alvarez, Sung Soo Mun, Jennifer Totonchy, Archana Gautam, Jesus Delgado de la Mora, Stephanie Chang, Dagmar Wirth, Marcelo Horenstein, Tao Dao, David A Scheinberg, Paul G Rubinstein, Aggrey Semeere, Jeffrey Martin, Catherine C Godfrey, Carlee B Moser, Roy M Matining, Thomas B Campbell, Margaret Z Borok, Susan E Krown, Ethel Cesarman
Publikováno v:
PLoS Pathogens, Vol 20, Iss 1, p e1011881 (2024)
In people living with HIV, Kaposi Sarcoma (KS), a vascular neoplasm caused by KS herpesvirus (KSHV/HHV-8), remains one of the most common malignancies worldwide. Individuals living with HIV, receiving otherwise effective antiretroviral therapy, may p
Externí odkaz:
https://doaj.org/article/fd71de1d5afd411097ac26c957e4cecc
Autor:
Bella Mehta, Susan Goodman, Edward DiCarlo, Deanna Jannat-Khah, J. Alex B. Gibbons, Miguel Otero, Laura Donlin, Tania Pannellini, William H. Robinson, Peter Sculco, Mark Figgie, Jose Rodriguez, Jessica M. Kirschmann, James Thompson, David Slater, Damon Frezza, Zhenxing Xu, Fei Wang, Dana E. Orange
Publikováno v:
Arthritis Research & Therapy, Vol 25, Iss 1, Pp 1-13 (2023)
Abstract Background We sought to identify features that distinguish osteoarthritis (OA) and rheumatoid arthritis (RA) hematoxylin and eosin (H&E)-stained synovial tissue samples. Methods We compared fourteen pathologist-scored histology features and
Externí odkaz:
https://doaj.org/article/7177784a35f941ac81d084f7ffcd9e30
Autor:
Steven Guan, Bella Mehta, David Slater, James R. Thompson, Edward DiCarlo, Tania Pannellini, Diyu Pearce‐Fisher, Fan Zhang, Soumya Raychaudhuri, Caryn Hale, Caroline S. Jiang, Susan Goodman, Dana E. Orange
Publikováno v:
ACR Open Rheumatology, Vol 4, Iss 4, Pp 322-331 (2022)
Objective We quantified inflammatory burden in rheumatoid arthritis (RA) synovial tissue by using computer vision to automate the process of counting individual nuclei in hematoxylin and eosin images. Methods We adapted and applied computer vision al
Externí odkaz:
https://doaj.org/article/100b7dbe76a34bc2acd9d0c3308df400
Autor:
Purva Singh, Mengying Wang, Piali Mukherjee, Samantha G. Lessard, Tania Pannellini, Camila B. Carballo, Scott A. Rodeo, Mary B. Goldring, Miguel Otero
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract In osteoarthritis (OA), articular chondrocytes display phenotypic and functional changes associated with epigenomic alterations. These changes contribute to the disease progression, which is characterized by dysregulated reparative processes
Externí odkaz:
https://doaj.org/article/007f070d6a774253b64601a71b7991cf
Autor:
Edd Ricker, Michela Manni, Danny Flores-Castro, Daniel Jenkins, Sanjay Gupta, Juan Rivera-Correa, Wenzhao Meng, Aaron M. Rosenfeld, Tania Pannellini, Mahesh Bachu, Yurii Chinenov, Peter K. Sculco, Rolf Jessberger, Eline T. Luning Prak, Alessandra B. Pernis
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
Autoimmunity mediated by age-associated B cells (ABC) can affect males and females differently. Here, using a lupus-like mouse model that affects females more severely, the authors observe an ABC mediated and guanine nucleotide exchange factor (GEF)
Externí odkaz:
https://doaj.org/article/908466dd2bb34f6fa842dde7cbf2d877
Autor:
Takayuki Fujii, Susumu Wada, Camila B. Carballo, Richard D. Bell, Wataru Morita, Yusuke Nakagawa, Yake Liu, Daoyun Chen, Tania Pannellini, Upneet K. Sokhi, Xiang‐hua Deng, Kyung Hyung Park‐Min, Scott A. Rodeo, Lionel B. Ivashkiv
Publikováno v:
JBMR Plus, Vol 6, Iss 7, Pp n/a-n/a (2022)
ABSTRACT Macrophages are important for repair of injured tissues, but their role in healing after surgical repair of musculoskeletal tissues is not well understood. We used single‐cell RNA sequencing (RNA‐seq), flow cytometry, and transcriptomics
Externí odkaz:
https://doaj.org/article/ebf7501d70ab4fe4ac913d1353baf8d0
Autor:
Peter Sculco, Milan Kapadia, Carine J. Moezinia, Insa Mannstadt, Andy O. Miller, Laura Donlin, Michael Henry, Linda Russell, Mark Figgie, Allina Nocon, Tania Pannellini, Susan M. Goodman
Publikováno v:
HSS Journal®: The Musculoskeletal Journal of Hospital for Special Surgery. 19:146-153
Background: Patients with inflammatory arthritis are at increased risk of prosthetic joint infections (PJIs), but diagnosis in these patients can be challenging because active inflammatory arthritis produces elevated inflammatory markers that may mim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a50b008da947252fefdbf6c517b3455
https://doi.org/10.1177/15563316231153395
https://doi.org/10.1177/15563316231153395
Autor:
Upneet K. Sokhi, Mark P. Liber, Laura Frye, Sungho Park, Kyuho Kang, Tania Pannellini, Baohong Zhao, Rada Norinsky, Lionel B. Ivashkiv, Shiaoching Gong
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
The human TNFAIP3 gene, which encodes for A20, is associated with autoimmune diseases. Here, the authors use BAC transgenics combined with CRISPR- and recombineering-mediated genome editing to dissect in vivo and in primary immune cells, the role of
Externí odkaz:
https://doaj.org/article/c6b3ebba7a6c4cca98a75c5a151f33d5