Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Tangzhi Zhang"'
Autor:
Vladimir Stepanov, Cathrine Jonsson, Lars Farde, Michael G. Stabin, Christer Halldin, Sjoerd J. Finnema, Tangzhi Zhang, Philip Seeman, Anna W. Sromek, Ryuji Nakao, John L. Neumeyer, Susan R. George
Publikováno v:
Journal of Nuclear Medicine. 55:1164-1170
PET has been used to examine changes in neurotransmitter concentrations in the living brain. Pioneering PET studies on the dopamine system have used D2 and D3 receptor (D2/D3) antagonists such as (11)C-raclopride. However, more recently developed ago
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06b7a2971e22c901e91529127ee73ebd
https://doi.org/10.2967/jnumed.113.133876
https://doi.org/10.2967/jnumed.113.133876
Autor:
Tangzhi Zhang, Brian I. Knapp, Jean M. Bidlack, Thomas Scrimale, Zhaohua Yan, Anna W. Sromek, John L. Neumeyer
Publikováno v:
Journal of Medicinal Chemistry. 54:1903-1913
A series of N-substituted and N'-substituted aminothiazole-derived morphinans (5) were synthesized for expanding the structure-activity relationships of aminothiazolo-morphinans. Although their affinities were somewhat lower than their prototype amin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37643bddbb5c1ff864be4bc9d82d1048
https://doi.org/10.1021/jm101542c
https://doi.org/10.1021/jm101542c
Publikováno v:
ACS Medicinal Chemistry Letters. 2:189-194
The 2-fluoroalkoxy substituted catechol-aporphines 6, 8a-f and 11-monohydroxyaporphines 11a-e were synthesized and found to have high in vitro affinity and selectivity for the dopamine D(2) receptors. The catechol aporphines, 8b and 8d, and the monoh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72db43736e1f1f187ab7665f93e5bab5
https://doi.org/10.1021/ml1001689
https://doi.org/10.1021/ml1001689
Autor:
Tangzhi Zhang, Jean M. Bidlack, Anna W. Sromek, Bin Zhang, John L. Neumeyer, Dana J. Cohen, Brian I. Knapp
Publikováno v:
Journal of medicinal chemistry. 55(8)
A series of 3-benzylamino-3-desoxymorphinan (I) and 3-benzylamino-3-desoxymorphine (II) derivatives were synthesized and evaluated for their binding affinities, and functional activity data are presented at MOR, KOR, and DOR. Some of these ligands we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cce160a9532a1849b18dcb43f742abec
https://pubmed.ncbi.nlm.nih.gov/22439881
https://pubmed.ncbi.nlm.nih.gov/22439881
Publikováno v:
ChemInform. 42
An organocatalytic enantioselective Friedel-Crafts reaction of 1-naphthols with aldimines has been developed. The method affords a direct access to chiral aminoarylnaphthols in good yields and with good to high enantioselectivities.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff22a10f4faef718523c5b8ccdf30b2e
https://doi.org/10.1002/chin.201120098
https://doi.org/10.1002/chin.201120098
Publikováno v:
Organic letters. 13(5)
An organocatalytic enantioselective Friedel-Crafts reaction of 1-naphthols with aldimines has been developed. The method affords a direct access to chiral aminoarylnaphthols in good yields and with good to high enantioselectivities.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44cf42fbc16be7323d3fb4e142bf074a
https://pubmed.ncbi.nlm.nih.gov/21235250
https://pubmed.ncbi.nlm.nih.gov/21235250
Publikováno v:
Bioorganicmedicinal chemistry. 19(9)
A novel series of homo- and heterodimeric ligands containing κ/μ agonist and μ agonist/antagonist pharmacophores joined by a 10-carbon ester linker chain were synthesized and evaluated for their in vitro binding affinity at κ, μ, and δ opioid r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94c755cf113b9d3a2dfc24a927dfebdf
https://pubmed.ncbi.nlm.nih.gov/21482470
https://pubmed.ncbi.nlm.nih.gov/21482470
Autor:
Zhaobing Gao, Meng Wu, Haiyan Sun, Qiaojie Xiong, Yinan Zhang, Min Li, Wei Wang, Liansuo Zu, Tangzhi Zhang
Kv7 channels, especially Kv7.2 (KCNQ2) and Kv7.3 (KCNQ3), are key determinants for membrane excitability in the brain. Some chemical modulators of KCNQ channels are in development for use as anti-epileptic drugs, such as retigabine (D-23129, N-(2-ami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c6ca9a9253107cf9f5cd23d4479782c
https://europepmc.org/articles/PMC2934696/
https://europepmc.org/articles/PMC2934696/
Publikováno v:
Organic Letters; Mar2011, Vol. 13 Issue 5, p828-831, 4p