Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Tanguy Jamier"'
Autor:
Zaher ElBeck, Mohammad Bakhtiar Hossain, Humam Siga, Nikolay Oskolkov, Fredrik Karlsson, Julia Lindgren, Anna Walentinsson, Dominique Koppenhöfer, Rebecca Jarvis, Roland Bürli, Tanguy Jamier, Elske Franssen, Mike Firth, Andrea Degasperi, Claus Bendtsen, Robert I. Menzies, Katrin Streckfuss-Bömeke, Michael Kohlhaas, Alexander G. Nickel, Lars H. Lund, Christoph Maack, Ákos Végvári, Christer Betsholtz
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)
Abstract While excessive production of reactive oxygen species (ROS) is a characteristic hallmark of numerous diseases, clinical approaches that ameliorate oxidative stress have been unsuccessful. Here, utilizing multi-omics, we demonstrate that in c
Externí odkaz:
https://doaj.org/article/8cb734f3e6db454ca663dbe7df2cc0bb
Autor:
M. Catarina Silva, Ghata A. Nandi, Sharon Tentarelli, Ian K. Gurrell, Tanguy Jamier, Diane Lucente, Bradford C. Dickerson, Dean G. Brown, Nicholas J. Brandon, Stephen J. Haggarty
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Disruption of autophagy function in cellular and animal models of tauopathy increases tau aggregation. Here, the authors describe a small-molecule screen to identify compounds that promote autophagy clearance of tau and rescue disease-relevant phenot
Externí odkaz:
https://doaj.org/article/8c984694d54f4d749b8a1bed03dbaffc
Autor:
Jayanth Chandran, Ekram Ahmed Chowdhury, Michael Perkinton, Tanguy Jamier, Daniel Sutton, Shengjia Wu, Claire Dobson, Dhaval K. Shah, Iain Chessell, Guy M. L. Meno-Tetang
Publikováno v:
Gene Therapy. 30:132-141
Challenges in obtaining efficient transduction of brain and spinal cord following systemic AAV delivery have led to alternative administration routes being used in clinical trials that directly infuse the virus into the CNS. However, data comparing d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ab71b708c17906eb4522af2651c7ec4
https://doi.org/10.1038/s41434-022-00346-1
https://doi.org/10.1038/s41434-022-00346-1
Autor:
Ekram Ahmed Chowdhury, Shengjia Wu, Hsueh-Yuan Chang, Hsien Wei Huang, Dhaval K. Shah, Guy Meno-Tetang, Jayanth Chandran, Tanguy Jamier
Publikováno v:
Advanced Drug Delivery Reviews. 170:214-237
While protein therapeutics are one of the most successful class of drug molecules, they are expensive and not suited for treating chronic disorders that require long-term dosing. Adeno-associated virus (AAV) mediated in vivo gene therapy represents a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::defa6b522e2e6e21f4fe7779e9cac4ef
https://doi.org/10.1016/j.addr.2021.01.017
https://doi.org/10.1016/j.addr.2021.01.017
Autor:
Zaher Elbeck, Mohammad Bakhtiar Hossain, Humam Siga, Nikolay Oskolkov, Fredrik Karlsson, Julia Lindgren, Anna Walentinsson, Cristobal Dos Remedios, Dominique Koppenhöfer, Rebecca Jarvis, Roland Bürli, Tanguy Jamier, Elske Franssen, Mike Firth, Andrea Degasperi, Claus Bendtsen, Jan Dudek, Michael Kohlhaas, Alexander G. Nickel, Lars H. Lund, Christoph Maack, Ákos Végvári, Christer Betsholtz
Excessive production of reactive oxygen species (ROS) is characteristic of numerous diseases, but most studies in this area have not considered the impact of endogenous antioxidative defenses. Here, utilizing multi-omics, we demonstrate that in cardi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e153b3159d4e22122f6aa6818cb7d0d3
https://doi.org/10.1101/2022.03.26.485908
https://doi.org/10.1101/2022.03.26.485908
Autor:
Stephen J. Haggarty, Bradford C. Dickerson, Diane Lucente, Dean G. Brown, Nicholas J. Brandon, Tanguy Jamier, Ian Gurrell, Ghata Nandi, Sharon Tentarelli, M. Catarina Silva
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Nature Communications
Nature Communications
Tauopathies are neurodegenerative diseases associated with accumulation of abnormal tau protein in the brain. Patient iPSC-derived neuronal cell models replicate disease-relevant phenotypes ex vivo that can be pharmacologically targeted for drug disc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9827598c95edf552d1ed282735d38a83
http://link.springer.com/article/10.1038/s41467-020-16984-1
http://link.springer.com/article/10.1038/s41467-020-16984-1
Autor:
Tanguy Jamier, Agnes Mallier, Kathryn Ball, Claire Denizot, Marylore Chenel, Yannick Parmentier
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 106
A PBPK modelling approach was used to predict organic anion transporter (OAT) mediated drug-drug interactions involving S44121, a substrate and an inhibitor of OAT1 and OAT3. Model predictions were then compared to the results of a clinical DDI study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1da6c8a5f3e718db10e632f5d5319931
https://pubmed.ncbi.nlm.nih.gov/28552429
https://pubmed.ncbi.nlm.nih.gov/28552429