Ruthenium(II) Polypyridyl Complexes for Antimicrobial Photodynamic Therapy: Prospects for Application in Cystic Fibrosis Lung Airways

Autor: Raphaëlle Youf, Adeel Nasir, Mareike Müller, Franck Thétiot, Tanguy Haute, Rosy Ghanem, Ulrich Jonas, Holger Schönherr, Gilles Lemercier, Tristan Montier, Tony Le Gall

Publikováno v: Pharmaceutics, Vol 14, Iss 8, p 1664 (2022)

Antimicrobial photodynamic therapy (aPDT) depends on a variety of parameters notably related to the photosensitizers used, the pathogens to target and the environment to operate. In a previous study using a series of Ruthenium(II) polypyridyl ([Ru(II

Externí odkaz: https://doaj.org/article/4ae796bf5835497f8b116f507c6f3135

Optimizations of In Vitro Mucus and Cell Culture Models to Better Predict In Vivo Gene Transfer in Pathological Lung Respiratory Airways: Cystic Fibrosis as an Example

Autor: Rosy Ghanem, Véronique Laurent, Philippe Roquefort, Tanguy Haute, Sophie Ramel, Tony Le Gall, Thierry Aubry, Tristan Montier

Publikováno v: Pharmaceutics, Vol 13, Iss 1, p 47 (2020)

The respiratory epithelium can be affected by many diseases that could be treated using aerosol gene therapy. Among these, cystic fibrosis (CF) is a lethal inherited disease characterized by airways complications, which determine the life expectancy

Externí odkaz: https://doaj.org/article/62383fc8d2bb413c99fc32e16440841b

DNA nuclear targeting sequences for enhanced non-viral gene transfer: An in vitro and in vivo study

Autor: Tristan Montier, Philippe Guégan, Sandrine Quemener, Kévin Pluchon, Juliette Ropars, Chantal Pichon, Tanguy Haute, Yann Thierry Le Guen, Tony Le Gall, Patrick Midoux

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 24, Iss, Pp 477-486 (2021)
Molecular Therapy-Nucleic Acids
Molecular Therapy-Nucleic Acids, 2021, 24, pp.477-486. ⟨10.1016/j.omtn.2021.03.012⟩
Molecular Therapy-Nucleic Acids, Elsevier, 2021, 24, pp.477-486. ⟨10.1016/j.omtn.2021.03.012⟩

International audience; An important bottleneck for non-viral gene transfer commonly relates to translocation of nucleic acids into the nuclear compartment of target cells. So-called 3NFs are optimized short nucleotide sequences able to interact with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c4a5b1f27897bb492e888401d28fe8f
http://www.sciencedirect.com/science/article/pii/S2162253121000834

Prospects of Ruthenium(II) Polypyridyl Complexes for Application in Cystic Fibrosis Lung Airways: Influence of Environmental Conditions in Antimicrobial Photodynamic Therapy

Autor: Raphaëlle YOUF, Adeel NASIR, Mareike MÜLLER, Franck THETIOT, Tanguy HAUTE, Rosy GHANEM, Ali BALASINI, Ulrich JONAS, Holger SCHÖNHERR, Gilles LEMERCIER, Tristan MONTIER, Tony Le GALL

Publikováno v: Photodiagnosis and Photodynamic Therapy. 41:103377

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6fe233692aba6d3efc551c570e0faed0
https://doi.org/10.1016/j.pdpdt.2023.103377

Apparent Yield Stress of Sputum as a Relevant Biomarker in Cystic Fibrosis

Autor: Tristan Montier, Véronique Laurent, Thierry Aubry, Tony Le Gall, Philippe Roquefort, Sophie Ramel, Tanguy Haute, Rosy Ghanem

Publikováno v: Cells
Cells, 2021, 10 (11), pp.3107. ⟨10.3390/cells10113107⟩
Cells, Vol 10, Iss 3107, p 3107 (2021)
Volume 10
Issue 11

International audience; The mucus obstructing the airways of Cystic Fibrosis (CF) patients is a yield stress fluid. Linear and non-linear rheological analyses of CF sputa can provide relevant biophysical markers, which could be used for the managemen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ed3825b7bb08f33699c82ed24f25ba8
https://hal.science/hal-03701679