Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Tanglong Yuan"'
Autor:
Leilei Wu, Shutan Jiang, Meisong Shi, Tanglong Yuan, Yaqin Li, Pinzheng Huang, Yingqi Li, Erwei Zuo, Changyang Zhou, Yidi Sun
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-22 (2024)
Abstract Background The safety of CRISPR-based gene editing methods is of the utmost priority in clinical applications. Previous studies have reported that Cas9 cleavage induced frequent aneuploidy in primary human T cells, but whether cleavage-media
Externí odkaz:
https://doaj.org/article/a173f9a0e0c44725899cd86c3aaab2fd
Autor:
Guoling Li, Xue Dong, Jiamin Luo, Tanglong Yuan, Tong Li, Guoli Zhao, Hainan Zhang, Jingxing Zhou, Zhenhai Zeng, Shuna Cui, Haoqiang Wang, Yin Wang, Yuyang Yu, Yuan Yuan, Erwei Zuo, Chunlong Xu, Jinhai Huang, Yingsi Zhou
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract The engineered TadA variants used in cytosine base editors (CBEs) present distinctive advantages, including a smaller size and fewer off-target effects compared to cytosine base editors that rely on natural deaminases. However, the current T
Externí odkaz:
https://doaj.org/article/22bf6bfde115440ca9a0bed39d657737
Autor:
Tanglong Yuan, Leilei Wu, Shiyan Li, Jitan Zheng, Nana Li, Xiao Xiao, Haihang Zhang, Tianyi Fei, Long Xie, Zhenrui Zuo, Di Li, Pinzheng Huang, Hu Feng, Yaqi Cao, Nana Yan, Xinming Wei, Lei Shi, Yongsen Sun, Wu Wei, Yidi Sun, Erwei Zuo
Publikováno v:
Cell Discovery, Vol 10, Iss 1, Pp 1-19 (2024)
Abstract Adenine base editors (ABEs) and cytosine base editors (CBEs) enable the single nucleotide editing of targeted DNA sites avoiding generation of double strand breaks, however, the genomic features that influence the outcomes of base editing in
Externí odkaz:
https://doaj.org/article/ee906f9bb38b4ed6871e389b587ab546
Autor:
Long Xie, Hu Feng, Zhifang Li, Di Li, Xiali Yang, Tanglong Yuan, Nana Yan, Chenfei He, Jitan Zheng, Zhenrui Zuo, Yaxuan Zheng, Yaqi Cao, Yangqing Lu, Xing Yao Xiong, Erwei Zuo
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-12 (2024)
Abstract The FokI catalytic domain can be fused to various DNA binding architectures to improve the precision of genome editing tools. However, evaluation of off-target effects is essential for developing these tools. We use Genome-wide Off-target an
Externí odkaz:
https://doaj.org/article/a9b485180cea48fa8539dfa79cd4b10a
Autor:
Guoling Li, Xue Dong, Jiamin Luo, Tanglong Yuan, Tong Li, Guoli Zhao, Hainan Zhang, Jingxing Zhou, Zhenhai Zeng, Shuna Cui, Haoqiang Wang, Yin Wang, Yuyang Yu, Yuan Yuan, Erwei Zuo, Chunlong Xu, Jinhai Huang, Yingsi Zhou
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/0f9e5762829149899ae663e3e4fd0a2e
Autor:
Nana Yan, Hu Feng, Yongsen Sun, Ying Xin, Haihang Zhang, Hongjiang Lu, Jitan Zheng, Chenfei He, Zhenrui Zuo, Tanglong Yuan, Nana Li, Long Xie, Wu Wei, Yidi Sun, Erwei Zuo
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
The potential off-target effects of long-term expression of base editors in vivo are unclear. Here the authors report SAFETI, Systematic evaluation Approach For gene Editing tools by Transgenic mIce, to examine off-target effects of base editors over
Externí odkaz:
https://doaj.org/article/471d0bf5b95947c2934db09d1720ed32
Autor:
Tanglong Yuan, Nana Yan, Tianyi Fei, Jitan Zheng, Juan Meng, Nana Li, Jing Liu, Haihang Zhang, Long Xie, Wenqin Ying, Di Li, Lei Shi, Yongsen Sun, Yongyao Li, Yixue Li, Yidi Sun, Erwei Zuo
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
C->G transversions can be highly desirable editing outcomes. Here the authors optimise CGBEs and provide a deep learning model for predicting editing outcomes based on sequence context.
Externí odkaz:
https://doaj.org/article/84852509bdb0448faac72ae929a50ecc
Autor:
Yuyao Li, Tanglong Yuan, Hongwei Zhang, Shuting Liu, Jie Lun, Jing Guo, Yu Wang, Yuying Zhang, Jing Fang
Publikováno v:
Acta Biochimica et Biophysica Sinica; Nov2023, Vol. 55 Issue 11, p1749-1757, 9p
Autor:
Long Xie, Wenqin Ying, Yixue Li, Erwei Zuo, Nana Yan, Di Li, Lei Shi, Nana Li, Tianyi Fei, Jitan Zheng, Yongyao Li, Yongsen Sun, Tanglong Yuan, Haihang Zhang, Yidi Sun, Jing Liu, Juan Meng
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications
Nature Communications
Efficient and precise base editors (BEs) for C-to-G transversion are highly desirable. However, the sequence context affecting editing outcome largely remains unclear. Here we report engineered C-to-G BEs of high efficiency and fidelity, with the seq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d7eebbe46bbf022f00abab719a42a4a
https://doaj.org/article/84852509bdb0448faac72ae929a50ecc
https://doaj.org/article/84852509bdb0448faac72ae929a50ecc
Autor:
Yingsi Zhou, Chunlong Xu, Xiang Wang, Tanglong Yuan, Yifan Wang, Guannan Geng, Bingbing He, Xiaona Huo, Weiya Bai, Zikang Wang, Jinsheng Lai, Xue Dong, Qingquan Xiao, Hui Yang, Dongming Zhou, Birong Cao
Publikováno v:
Nature Methods. 18:499-506
Competitive coevolution between microbes and viruses has led to the diversification of CRISPR-Cas defense systems against infectious agents. By analyzing metagenomic terabase datasets, we identified two compact families (775 to 803 amino acids (aa))
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8ac8a92f8c28d5968450ea7d081c922
https://doi.org/10.1038/s41592-021-01124-4
https://doi.org/10.1038/s41592-021-01124-4