Non-parametric mixture models identify trajectories of childhood immune development relevant to asthma and allergy

Autor: Tang, HHF, Teo, SM, Belgrave, DCM, Evans, M, Jackson, D, Brozynska, M, Kusel, MMH, Johnston, S, Gern, J, Lemanske, R, Simpson, A, Custovic, A, Sly, P, Holt, P, Holt, K, Inouye, M

Events in early life contribute to subsequent risk of asthma; however, the causes and trajectories of childhood wheeze are heterogeneous and do not always result in asthma. Similarly, not all atopic individuals develop wheeze, and vice versa. The rea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::4637ecfc5c423ab070f6d3a052a458d6
http://hdl.handle.net/10044/1/63017

Developmental patterns in the nasopharyngeal microbiome during infancy are associated with asthma risk.

Autor: Tang HHF; Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, Australia; Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; School of BioSciences, University of Melbourne, Melbourne, Australia., Lang A; Department of Pediatrics, University of Wisconsin-Madison, Madison, Wis., Teo SM; Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, Australia; Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom., Judd LM; Department of Infectious Diseases, Central Clinical School, Monash University, Melbourne, Australia., Gangnon R; Department of Biomedical Informatics, University of Wisconsin-Madison, Madison, Wis., Evans MD; Department of Biomedical Informatics, University of Wisconsin-Madison, Madison, Wis., Lee KE; Department of Biomedical Informatics, University of Wisconsin-Madison, Madison, Wis., Vrtis R; Department of Pediatrics, University of Wisconsin-Madison, Madison, Wis., Holt PG; Children's Telethon Institute and the University of Western Australia, Perth, Australia., Lemanske RF Jr; Department of Pediatrics, University of Wisconsin-Madison, Madison, Wis., Jackson DJ; Department of Pediatrics, University of Wisconsin-Madison, Madison, Wis., Holt KE; Department of Infectious Diseases, Central Clinical School, Monash University, Melbourne, Australia; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom., Inouye M; Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, Australia; Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; The Alan Turing Institute, London, United Kingdom., Gern JE; Department of Pediatrics, University of Wisconsin-Madison, Madison, Wis. Electronic address: gern@medicine.wisc.edu.

Publikováno v: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2021 May; Vol. 147 (5), pp. 1683-1691. Date of Electronic Publication: 2020 Oct 19.

Neonatal genetics of gene expression reveal potential origins of autoimmune and allergic disease risk.

Autor: Huang QQ; Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, VIC, 3004, Australia. qh1@sanger.ac.uk.; Department of Clinical Pathology, University of Melbourne, Parkville, VIC, 3010, Australia. qh1@sanger.ac.uk.; Department of Human Genetics, Wellcome Sanger Institute, Cambridge, UK. qh1@sanger.ac.uk., Tang HHF; Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, VIC, 3004, Australia.; School of BioSciences, The University of Melbourne, Parkville, VIC, 3010, Australia., Teo SM; Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, VIC, 3004, Australia.; Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK., Mok D; Telethon Kids Institute, The University of Western Australia, Perth, WA, 6009, Australia., Ritchie SC; Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, VIC, 3004, Australia.; Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, UK., Nath AP; Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, VIC, 3004, Australia.; Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK., Brozynska M; Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, VIC, 3004, Australia.; Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK., Salim A; Baker Heart and Diabetes Institute, Melbourne, VIC, 3004, Australia.; School of Mathematics and Statistics, The University of Melbourne, Parkville, VIC, 3010, Australia.; Melbourne School of Population and Global Health, Carlton, VIC, 3053, Australia., Bakshi A; Monash Biomedicine Discovery Institute, Prostate Cancer Research Group, Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, 3800, Australia., Holt BJ; Telethon Kids Institute, The University of Western Australia, Perth, WA, 6009, Australia., Khor CC; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, 138672, Singapore.; Singapore Eye Research Institute, Singapore, Singapore.; Duke-NUS Medical School, Singapore, Singapore., Sly PD; Child Health Research Centre, The University of Queensland, Brisbane, QLD, 4101, Australia., Holt PG; Telethon Kids Institute, The University of Western Australia, Perth, WA, 6009, Australia.; Child Health Research Centre, The University of Queensland, Brisbane, QLD, 4101, Australia., Holt KE; Department of Infectious Diseases, Central Clinical School, Monash University, Melbourne, VIC, 3004, Australia.; The London School of Hygiene and Tropical Medicine, London, WC1E 7TH, UK., Inouye M; Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, VIC, 3004, Australia. minouye@baker.edu.au.; Department of Clinical Pathology, University of Melbourne, Parkville, VIC, 3010, Australia. minouye@baker.edu.au.; Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK. minouye@baker.edu.au.; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. minouye@baker.edu.au.; National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, UK. minouye@baker.edu.au.; The Alan Turing Institute, London, UK. minouye@baker.edu.au.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK. minouye@baker.edu.au.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK. minouye@baker.edu.au.

Publikováno v: Nature communications [Nat Commun] 2020 Jul 28; Vol. 11 (1), pp. 3761. Date of Electronic Publication: 2020 Jul 28.

Airway Microbiota Dynamics Uncover a Critical Window for Interplay of Pathogenic Bacteria and Allergy in Childhood Respiratory Disease.

Autor: Teo SM; Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia; Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia., Tang HHF; Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia; Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK; School of BioSciences, The University of Melbourne, Parkville, VIC 3010, Australia., Mok D; Telethon Kids Institute, The University of Western Australia, West Perth, WA, Australia., Judd LM; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia., Watts SC; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia., Pham K; Department of Clinical Pathology, The University of Melbourne, Parkville, VIC 3010, Australia., Holt BJ; Telethon Kids Institute, The University of Western Australia, West Perth, WA, Australia., Kusel M; Telethon Kids Institute, The University of Western Australia, West Perth, WA, Australia., Serralha M; Telethon Kids Institute, The University of Western Australia, West Perth, WA, Australia., Troy N; Telethon Kids Institute, The University of Western Australia, West Perth, WA, Australia., Bochkov YA; University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA., Grindle K; University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA., Lemanske RF Jr; University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA., Johnston SL; Airway Disease Infection Section and MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, National Heart and Lung Institute, Imperial College London, Norfolk Place, London W2 1PG, UK., Gern JE; University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA., Sly PD; Child Health Research Centre, The University of Queensland, Brisbane 4101, Australia., Holt PG; Telethon Kids Institute, The University of Western Australia, West Perth, WA, Australia; Child Health Research Centre, The University of Queensland, Brisbane 4101, Australia., Holt KE; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia; Telethon Kids Institute, The University of Western Australia, West Perth, WA, Australia; The London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK. Electronic address: kholt@unimelb.edu.au., Inouye M; Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia; Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK; School of BioSciences, The University of Melbourne, Parkville, VIC 3010, Australia; Telethon Kids Institute, The University of Western Australia, West Perth, WA, Australia; Department of Clinical Pathology, The University of Melbourne, Parkville, VIC 3010, Australia; The Alan Turing Institute, London, UK. Electronic address: mi336@medschl.cam.ac.uk.

Publikováno v: Cell host & microbe [Cell Host Microbe] 2018 Sep 12; Vol. 24 (3), pp. 341-352.e5.