Targeting histone deacetylase in lung cancer for early diagnosis: (18)F-FAHA PET/CT imaging of NNK-treated A/J mice model

Autor: Tang, Wayland, Kuruvilla, Sharon A, Galitovskiy, Valentin, Pan, Min-Liang, Grando, Sergei A, Mukherjee, Jogeshwar

Publikováno v: American journal of nuclear medicine and molecular imaging, vol 4, iss 4

Elevated levels of histone deacetylases (HDACs) have been indicated in the development of some cancers. HDAC has been imaged using (18)F-FAHA and may serve as a marker to study epigenetics. We report evaluation of (18)F-FAHA as a probe in the early d

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https://escholarship.org/uc/item/8k0810gr

Targeting histone deacetylase in lung cancer for early diagnosis: (18)F-FAHA PET/CT imaging of NNK-treated A/J mice model.

Autor: Tang W; Preclinical Imaging, Department of Radiological Sciences, University of California Irvine, California 92697, USA., Kuruvilla SA; Preclinical Imaging, Department of Radiological Sciences, University of California Irvine, California 92697, USA., Galitovskiy V; Cancer Center and Research Institute, University of California Irvine, California 92697, USA., Pan ML; Preclinical Imaging, Department of Radiological Sciences, University of California Irvine, California 92697, USA., Grando SA; Department of Dermatology, University of California Irvine, California 92697, USA ; Cancer Center and Research Institute, University of California Irvine, California 92697, USA., Mukherjee J; Preclinical Imaging, Department of Radiological Sciences, University of California Irvine, California 92697, USA ; Cancer Center and Research Institute, University of California Irvine, California 92697, USA.

Publikováno v: American journal of nuclear medicine and molecular imaging [Am J Nucl Med Mol Imaging] 2014 Jun 07; Vol. 4 (4), pp. 324-32. Date of Electronic Publication: 2014 Jun 07 (Print Publication: 2014).