Chemogenetic investigation of amyotrophic lateral sclerosis (ALS): controlling signaling in astrocytes and in motoneurons to affect disease manifestations in an ALS mouse model

Autor: Tang, Linyun

Background and purpose: Amyotrophic lateral sclerosis (ALS) is among the fatal neurodegenerative diseases that lack widely available effective treatments. Extensive evidence shows that the pathogenic cascade of ALS is associated with a non-cell auton

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NF‐κB activation in astrocytes drives a stage‐specific beneficial neuroimmunological response in ALS.

Autor: Ouali Alami, Najwa, Schurr, Christine, Olde Heuvel, Florian, Tang, Linyun, Li, Qian, Tasdogan, Alpaslan, Kimbara, Atsushi, Nettekoven, Matthias, Ottaviani, Giorgio, Raposo, Catarina, Röver, Stephan, Rogers‐Evans, Mark, Rothenhäusler, Benno, Ullmer, Christoph, Fingerle, Jürgen, Grether, Uwe, Knuesel, Irene, Boeckers, Tobias M., Ludolph, Albert, Wirth, Thomas

Publikováno v: EMBO Journal; Aug2018, Vol. 37 Issue 16, p1-1, 23p, 12 Color Photographs, 1 Diagram, 2 Charts, 7 Graphs

Multiplexed chemogenetics in astrocytes and motoneurons restore blood-spinal cord barrier in ALS.

Autor: Ouali Alami N; Department of Neurology, Ulm University, Ulm, Germany.; International Graduate School in Molecular Medicine Ulm, Ulm, Germany.; Department of Neurology, Clinical Neuroanatomy, Ulm University, Ulm, Germany., Tang L; Department of Neurology, Ulm University, Ulm, Germany., Wiesner D; Department of Neurology, Ulm University, Ulm, Germany.; German Center for Neurodegenerative Diseases (DZNE), Ulm, Germany., Commisso B; Department of Neurology, Ulm University, Ulm, Germany., Bayer D; Department of Neurology, Ulm University, Ulm, Germany.; CEMMA Graduate School, Ulm University, Ulm, Germany., Weishaupt J; Department of Neurology, Ulm University, Ulm, Germany., Dupuis L; Inserm U1118, Mécanismes Centraux et Périphériques de la Neurodégénérescence; Université de Strasbourg, Faculté de Médecine, Strasbourg, France., Wong P; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Baumann B; Institute of Physiological Chemistry, Ulm University, Ulm, Germany., Wirth T; Institute of Physiological Chemistry, Ulm University, Ulm, Germany., Boeckers TM; German Center for Neurodegenerative Diseases (DZNE), Ulm, Germany.; Department of Anatomy and Cell Biology, Ulm University, Ulm, Germany., Yilmazer-Hanke D; Department of Neurology, Clinical Neuroanatomy, Ulm University, Ulm, Germany., Ludolph A; Department of Neurology, Ulm University, Ulm, Germany.; German Center for Neurodegenerative Diseases (DZNE), Ulm, Germany., Roselli F; Department of Neurology, Ulm University, Ulm, Germany francesco.roselli@uni-ulm.de.; German Center for Neurodegenerative Diseases (DZNE), Ulm, Germany.

Publikováno v: Life science alliance [Life Sci Alliance] 2020 Sep 08; Vol. 3 (11). Date of Electronic Publication: 2020 Sep 08 (Print Publication: 2020).