CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors

Autor: Renaud, Le Floch, Johanna, Chiche, Ibtissam, Marchiq, Tanesha, Naiken, Tanesha, Naïken, Karine, Ilc, Karine, Ilk, Clare M, Murray, Susan E, Critchlow, Danièle, Roux, Marie-Pierre, Simon, Jacques, Pouysségur

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2011, 108 (40), pp.16663-8. ⟨10.1073/pnas.1106123108⟩
Proceedings of the National Academy of Sciences; Vol 108

Malignant tumors exhibit increased dependence on glycolysis, resulting in abundant export of lactic acid, a hypothesized key step in tumorigenesis. Lactic acid is mainly transported by two H + /lactate symporters, MCT1/MCT4, that require the ancillar

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https://hal.archives-ouvertes.fr/hal-00756626