Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Tanes Lima"'
Autor:
Martin Wohlwend, Pirkka-Pekka Laurila, Ludger JE Goeminne, Tanes Lima, Ioanna Daskalaki, Xiaoxu Li, Giacomo von Alvensleben, Barbara Crisol, Renata Mangione, Hector Gallart-Ayala, Amélia Lalou, Olivier Burri, Stephen Butler, Jonathan Morris, Nigel Turner, Julijana Ivanisevic, Johan Auwerx
Publikováno v:
eLife, Vol 12 (2024)
Age-related muscle wasting and dysfunction render the elderly population vulnerable and incapacitated, while underlying mechanisms are poorly understood. Here, we implicate the CERS1 enzyme of the de novo sphingolipid synthesis pathway in the pathoge
Externí odkaz:
https://doaj.org/article/d20d88bab189434da372a5ca93b464e3
Autor:
Stela Mirla da Silva Felipe, Raquel Martins de Freitas, Emanuel Diego dos Santos Penha, Christina Pacheco, Danilo Lopes Martins, Juliana Osório Alves, Paula Matias Soares, Adriano César Carneiro Loureiro, Tanes Lima, Leonardo R. Silveira, Alex Soares Marreiros Ferraz, Jorge Estefano Santana de Souza, Jose Henrique Leal-Cardoso, Denise P. Carvalho, Vania Marilande Ceccatto
Publikováno v:
PeerJ, Vol 9, p e10500 (2021)
Background Physical exercise is a health promotion factor regulating gene expression and causing changes in phenotype, varying according to exercise type and intensity. Acute strenuous exercise in sedentary individuals appears to induce different tra
Externí odkaz:
https://doaj.org/article/2923411e0802483d913e105a31b28fc9
Publikováno v:
Nature Aging. 2:199-213
Aging is typified by a progressive decline in mitochondrial activity and stress resilience. Here, we review how mitochondrial stress pathways have pleiotropic effects on cellular and systemic homeostasis, which can comprise protective or detrimental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aec61ed92bb24dc8a02ea839a7cb84be
https://doi.org/10.1038/s43587-022-00191-2
https://doi.org/10.1038/s43587-022-00191-2
Autor:
Terytty Yang Li, Arwen W. Gao, Xiaoxu Li, Yasmine J. Liu, Rachel N. Arey, Kimberly Morales, Amélia Lalou, Qi Wang, Tanes Lima, Johan Auwerx
SUMMARYLysosomes are cytoplasmic organelles central for the degradation of macromolecules to maintain cellular homeostasis and health. Here, we discovered an adaptive lysosomal transcriptional response that we termed the Lysosomal Surveillance Respon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dff5252bd7e5c582e38600e1a8453f17
https://doi.org/10.1101/2022.06.13.495962
https://doi.org/10.1101/2022.06.13.495962
Autor:
Martin, Wohlwend, Pirkka-Pekka, Laurila, Kristine, Williams, Mario, Romani, Tanes, Lima, Pattamaprapanont, Pattawaran, Giorgia, Benegiamo, Minna, Salonen, Bernard L, Schneider, Jari, Lahti, Johan G, Eriksson, Romain, Barrès, Ulrik, Wisløff, José B N, Moreira, Johan, Auwerx
Publikováno v:
Science translational medicine. 13(623)
Skeletal muscle displays remarkable plasticity upon exercise and is also one of the organs most affected by aging. Despite robust evidence that aging is associated with loss of fast-twitch (type II) muscle fibers, the underlying mechanisms remain to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::21849eff9c56489718bc0475fc9588b3
https://pubmed.ncbi.nlm.nih.gov/34878822
https://pubmed.ncbi.nlm.nih.gov/34878822
Autor:
Martin Wohlwend, Pirkka-Pekka Laurila, Kristine Williams, Mario Romani, Tanes Lima, Pattamaprapanont Pattawaran, Giorgia Benegiamo, Minna Salonen, Bernard L. Schneider, Jari Lahti, Johan G. Eriksson, Romain Barrès, Ulrik Wisløff, José B. N. Moreira, Johan Auwerx
Skeletal muscle displays remarkable plasticity upon exercise and is also one of the organs most affected by aging. Despite robust evidence that aging is associated with loss of fast-twitch (type II) muscle fibers, the underlying mechanisms remain to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97336915b4cb748b7c3d24f836ed73a3
https://infoscience.epfl.ch/record/290839
https://infoscience.epfl.ch/record/290839