Sex-specific microglia state in the Neuroligin-4 knock-out mouse model of autism spectrum disorder

Autor: Dilansu Guneykaya, Bilge Ugursu, Francesca Logiacco, Oliver Popp, Maria Almut Feiks, Niklas Meyer, Stefan Wendt, Marcus Semtner, Fatma Cherif, Christian Gauthier, Charlotte Madore, Zhuoran Yin, Özcan Çınar, Taner Arslan, Zoltan Gerevich, Philipp Mertins, Oleg Butovsky, Helmut Kettenmann, Susanne A. Wolf

Publikováno v: Brain, Behavior, and Immunity. 111:61-75

Neuroligin-4 (NLGN4) loss-of-function mutations are associated with monogenic heritable autism spectrum disorder (ASD) and cause alterations in both synaptic and behavioral phenotypes. Microglia, the resident CNS macrophages, are implicated in ASD de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4718b55d1eec4a401ca2d25fcfb7308d
https://doi.org/10.1016/j.bbi.2023.03.023

Ion-imprinted CDs-Pc nanohybrid sensor for ratiometric fluorescence and electrochemical detection of Pd(II)

Autor: Taner Arslan, Sevgi Güney, Orhan Güney

Publikováno v: Sensors and Actuators B: Chemical. 377:133079

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::acdc317965cea919a6fd49c93c241015
https://doi.org/10.1016/j.snb.2022.133079

STK11 pathway in vitro validation

Autor: Ioannis Siavelis, Elsa Arbajian, Hassan Foroughi Asl, Mohammad Pirmoradian, David Tamborero, Husen M. Umer, Henrik J. Johansson, Vilde Drageset Haakensen, Olena Berkovska, Georgios Mermelekas, Johan Staaf, Janne Lehtiö, Odd Terje Brustugun, Anna Karlsson, Krishna Pinganksha Purohit, Richard Cunningham, Yanbo Pan, Taner Arslan, Rui M. Branca, Lukas M. Orre, Carsten Gram Hanson, Fabio Socciarelli, Åslaug Helland, Hans Brunnström, Sofi Isaksson, Mattias Aine, Marija Kotevska, Mats Jonsson

The associated publication reports proteogenomic analysis of non-small cell lung cancer (NSCLC), where we identified molecular subtypes with distinct immune evasion mechanisms and therapeutic targets, and validated our classification method in separa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a7ff17a8e81edef7889b7dde9b70adc
https://doi.org/10.21203/rs.3.pex-1561/v1

Immune landscape evaluation of NSCLC clinical samples

Autor: Carsten Gram Hanson, Maria Planck, Åslaug Helland, Georgios Mermelekas, Taner Arslan, Lukas M. Orre, Husen M. Umer, Fabio Socciarelli, Vilde Drageset Haakensen, David Tamborero, Mohammad Pirmoradian, Sofi Isaksson, Olena Berkovska, Richard Cunningham, Odd Terje Brustugun, Yanbo Pan, Rui M. Branca, Henrik J. Johansson, Hans Brunnström, Mats Jonsson, Janne Lehtiö, Anna Karlsson, Mattias Aine, Ioannis Siavelis, Elsa Arbajian, Hassan Foroughi Asl, Marija Kotevska, Krishna Pinganksha Purohit, Johan Staaf

The associated publication reports proteogenomic analysis of non-small cell lung cancer, where we identified molecular subtypes with distinct immune evasion mechanisms and therapeutic targets, and validated our classification method in separate clini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d582874e516d1ddc4cf79eefbc50ba85
https://doi.org/10.21203/rs.3.pex-1565/v1

Proteogenomics of non-small cell lung cancer reveals molecular subtypes associated with specific therapeutic targets and immune evasion mechanisms

Autor: Henrik J. Johansson, Marija Kotevska, Rui M. M. Branca, Sofi Isaksson, Krishna Pinganksha Purohit, Carsten G. Hansen, Mohammad Pirmoradian, Georgios Mermelekas, Odd Terje Brustugun, Olena Berkovska, David Tamborero, Richard Cunningham, Husen M. Umer, Janne Lehtiö, Yanbo Pan, Maria Planck, Åslaug Helland, Lukas M. Orre, Fabio Socciarelli, Taner Arslan, Anna Karlsson, Mats Jönsson, Elsa Arbajian, Hassan Foroughi Asl, Vilde Drageset Haakensen, Ioannis Siavelis, Mattias Aine, Johan Staaf, Hans Brunnström

Publikováno v: Nature Cancer
Lehtiö, J, Arslan, T, Siavelis, I, Pan, Y, Socciarelli, F, Berkovska, O, Umer, H M, Mermelekas, G, Pirmoradian, M, Jönsson, M, Brunnström, H, Brustugun, O T, Purohit, K P, Cunningham, R, Foroughi Asl, H, Isaksson, S, Arbajian, E, Aine, M, Karlsson, A, Kotevska, M, Gram Hansen, C, Drageset Haakensen, V, Helland, Å, Tamborero, D, Johansson, H J, Branca, R M, Planck, M, Staaf, J & Orre, L M 2021, ' Proteogenomics of non-small cell lung cancer reveals molecular subtypes associated with specific therapeutic targets and immune-evasion mechanisms ', nature cancer, vol. 2, no. 11, pp. 1224-1242 . https://doi.org/10.1038/s43018-021-00259-9

Despite major advancements in lung cancer treatment, long-term survival is still rare and a deeper understanding of molecular phenotypes would allow the identification of specific cancer dependencies and immune-evasion mechanisms. Here we performed i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8af0d696185c5ea5334a160bc13b493