Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function

Autor: Jean C, Chen XL, Nam JO, Tancioni I, Uryu S, Lawson C, Ward KK, Walsh CT, Miller NL, Ghassemian M, Turowski P, Dejana E, Weis S, Cheresh DA, Schlaepfer DD.

Publikováno v: J Cell Biol.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=erc_________::f929aa9fbf2318bc80dffc4b931780f5

A non-canonical role for Rgnef in promoting integrin-stimulated focal adhesion kinase activation

Autor: Miller, NLG, Lawson, C, Kleinschmidt, EG, Tancioni, I, Uryu, S, Schlaepfer, DD

Publikováno v: Journal of cell science, vol 126, iss Pt 21
Miller, NLG; Lawson, C; Kleinschmidt, EG; Tancioni, I; Uryu, S; & Schlaepfer, DD. (2013). A non-canonical role for Rgnef in promoting integrin-stimulated focal adhesion kinase activation. Journal of Cell Science, 126(21), 5074-5085. doi: 10.1242/jcs.135509. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/7cn9922v

Rgnef (also known as p190RhoGEF or ARHGEF28) is a Rho guanine-nucleotide-exchange factor (GEF) that binds focal adhesion kinase (FAK). FAK is recruited to adhesions and activated by integrin receptors binding to matrix proteins, such as fibronectin (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8a3628b2b75e185ab4cddadfce6d2eb0
https://europepmc.org/articles/PMC3820247/

Low merlin level is a biomarker for the sensitivity of ovarian carcinoma cells to focal adhesion kinase (FAK) inhibition

Autor: Shah, N.R., Tancioni, I., Ward, K.K., Lawson, C., Chen, X.L., Jean, C., Sulzmaier, F.J., Uryu, S., Connolly, D.C., Schlaepfer, D.D.

Publikováno v: In Gynecologic Oncology November 2014 135(2):386-386

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