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Akademický článek

Molecular profiling of pre- and post-treatment pediatric high-grade astrocytomas reveals acquired increased tumor mutation burden in a subset of recurrences

Autor: Matthew D. Wood, Carol Beadling, Tanaya Neff, Steve Moore, Christina A. Harrington, Lissa Baird, Christopher Corless

Publikováno v: Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-10 (2023)

Abstract Diffuse gliomas are a heterogeneous category of primary central nervous system tumors. Due to their infiltrative growth precluding complete surgical resection, most diffuse high-grade gliomas are treated with adjuvant chemotherapy and radiat

Externí odkaz: https://doaj.org/article/988be2512a1143a4adfbe50bdccf071b

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Akademický článek

Infantile fibrosarcoma with a novel RAF1 rearrangement: The contemporary challenge of reconciling classic morphology with novel molecular genetics

Autor: Cheryl M. Coffin, Carol Beadling, Tanaya Neff, Christopher L. Corless, Jessica L. Davis

Publikováno v: Human Pathology: Case Reports, Vol 22, Iss , Pp 200434- (2020)

Since the discovery of the ETV6-NTRK3 gene fusion in infantile fibrosarcoma two decades ago, it has become an important diagnostic marker because it is found in the majority of cases. However, the development of new molecular tests, including next ge

Externí odkaz: https://doaj.org/article/7e38d56c477443c48ea4b44692cf3cfc

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Data from Genetic Profiling to Determine Risk of Relapse-Free Survival in High-Risk Localized Prostate Cancer

Autor: Tomasz M. Beer, George V. Thomas, Christopher L. Corless, David Qian, Mark Garzotto, Celestia S. Higano, Tanaya Neff, Andrea Warrick, Carol Beadling, Dylan Nelson, Jeong Lim, Michael C. Heinrich, Christine M. Barnett

Purpose: The characterization of actionable mutations in human tumors is a prerequisite for the development of individualized, targeted therapy. We examined the prevalence of potentially therapeutically actionable mutations in patients with high-risk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44cb6ef748c50c11106dd9432943bd69
https://doi.org/10.1158/1078-0432.c.6521682

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Novel BRAF gene fusions and activating point mutations in spindle cell sarcomas with histologic overlap with infantile fibrosarcoma

Autor: Brandon T. Larsen, Alyaa Al-Ibraheemi, Jessica L. Davis, Yajuan J. Liu, Tanaya Neff, Michael Michal, Karen Fritchie, Carol Beadling, Christina M. Lockwood, Soo-Jin Cho, Erin R. Rudzinski, Alyssa J. Penning, Christopher L. Corless, Vera A. Paulson, Lukáš Plank

Publikováno v: Modern Pathology. 34:1530-1540

Infantile fibrosarcoma (IFS)/cellular congenital mesoblastic nephroma (cCMN) commonly harbors the classic ETV6-NTRK3 translocation. However, there are recent reports of mesenchymal tumors with IFS-like morphology harboring fusions of other receptor t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::084f3c15bdd215b78efd0bf21f8218e0
https://doi.org/10.1038/s41379-021-00806-w

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Mechanisms of targeted therapy resistance in a pediatric glioma driven by

Autor: Clare, Keddy, Tanaya, Neff, Jianya, Huan, Joshua P, Nickerson, Catherine Z, Beach, Yassmine, Akkari, Jianling, Ji, Stephen, Moore, Kellie J, Nazemi, Christopher L, Corless, Carol, Beadling, Randy, Woltjer, Yoon-Jae, Cho, Matthew D, Wood, Monika A, Davare

Publikováno v: Cold Spring Harbor Molecular Case Studies

Chromosomal rearrangements of the NTRK genes generate kinase fusions that are targetable oncogenic drivers in diverse adult and pediatric malignancies. Despite robust clinical response to targeted NTRK inhibition, the emergence of therapeutic resista

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0e44ec266f980cbac6953532a44fe483
https://pubmed.ncbi.nlm.nih.gov/34429303

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GAB1-ABL1 fusions in tumors that have histologic overlap with NTRK-rearranged spindle cell tumors

Autor: Jason Y. Park, Lara E. Davis, Charles F. Timmons, Carol Beadling, Jessica L. Davis, Christopher L. Corless, Monika A. Davare, Florence Choo, Tanaya Neff, Dinesh Rakheja

Publikováno v: Genes, chromosomescancerREFERENCES. 60(9)

Fibroblastic spindle cell tumors are a heterogeneous group of rare soft tissue tumors that are increasingly recognized as associated with a variety of kinase gene fusions. We report two cases of GAB1-ABL1 fusions in spindle cell tumors that histologi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fc09af0bccfa37475c6d12ea50d02c5
https://pubmed.ncbi.nlm.nih.gov/34036664

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