Zobrazeno 1 - 10
of 272
pro vyhledávání: '"Tanay T"'
Autor:
Wendy Leung, Ryan M. Baxley, Emma Traband, Ya-Chu Chang, Colette B. Rogers, Liangjun Wang, Wesley Durrett, Kendall S. Bromley, Lidia Fiedorowicz, Tanay Thakar, Anika Tella, Alexandra Sobeck, Eric A. Hendrickson, George-Lucian Moldovan, Naoko Shima, Anja-Katrin Bielinsky
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113523- (2023)
Summary: Ubiquitination of proliferating cell nuclear antigen (PCNA) at lysine 164 (K164) activates DNA damage tolerance pathways. Currently, we lack a comprehensive understanding of how PCNA K164 ubiquitination promotes genome stability. To evaluate
Externí odkaz:
https://doaj.org/article/0ee3d1a6203142ac8d65a9bb37a15e23
Publikováno v:
Sensors, Vol 24, Iss 11, p 3441 (2024)
An investigation was performed to develop a process to design and manufacture a 3-D smart skin with an embedded network of distributed sensors for non-developable (or doubly curved) surfaces. A smart skin is the sensing component of a smart structure
Externí odkaz:
https://doaj.org/article/1d87a4e21c15405d98bca21b31a46a28
Publikováno v:
Crime Science; 8/5/2020, Vol. 9 Issue 1, p1-13, 13p
Autor:
Tanay Thakar, Ashna Dhoonmoon, Joshua Straka, Emily M. Schleicher, Claudia M. Nicolae, George-Lucian Moldovan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Efficient DNA replication is crucial for genome stability. Here, Thakar et al. report that accumulation of lagging strand ssDNA gaps during replication interferes with nucleosome assembly and drives replication fork degradation in BRCA-deficient cell
Externí odkaz:
https://doaj.org/article/2dd4e50ca1d340f4ae9cf8bf31f43a9d
Akademický článek
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Autor:
Arindam Datta, Kajal Biswas, Joshua A. Sommers, Haley Thompson, Sanket Awate, Claudia M. Nicolae, Tanay Thakar, George-Lucian Moldovan, Robert H. Shoemaker, Shyam K. Sharan, Robert M. Brosh
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
The tumor suppressor BRCA2 protects stalled DNA replication forks from unrestrained degradation; however the mechanism whereby unprotected stalled forks are preserved and restarted has remained elusive. Here the authors show that the WRN helicase pro
Externí odkaz:
https://doaj.org/article/dd9a83371d84474f8a570030b092cfce
Publikováno v:
Fundamental Issues of Artificial Intelligence; 2016, p367-388, 22p
Akademický článek
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Autor:
Kristen E. Clements, Emily M. Schleicher, Tanay Thakar, Anastasia Hale, Ashna Dhoonmoon, Nathanial J. Tolman, Anchal Sharma, Xinwen Liang, Yuka Imamura Kawasawa, Claudia M. Nicolae, Hong-Gang Wang, Subhajyoti De, George-Lucian Moldovan
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Mutations in the homologous recombination proteins BRCA1 and BRCA2 can sensitize cells to treatment with inhibitors of poly-ADP-ribose polymerase 1 (PARPi), but resistance to the treatment can occur. Here the authors by genome-wide CRISPR knockout an
Externí odkaz:
https://doaj.org/article/bbee1b004cdc4bdebae2ddc9b6d5a3f3
Autor:
Tanay Thakar, Wendy Leung, Claudia M. Nicolae, Kristen E. Clements, Binghui Shen, Anja-Katrin Bielinsky, George-Lucian Moldovan
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
PCNA is essential for DNA replication and cellular proliferation. Here, the authors reveal that PCNA ubiquitination protects stalled replication forks from DNA2-mediated degradation via regulation of Okazaki fragment maturation and chromatin assembly
Externí odkaz:
https://doaj.org/article/83d73c42ce554d03b39eb16def8e823b