Systemic and stratum corneum biomarkers of severity in infant AD include markers of innate and Th-related immunity and angiogenesis

Autor: McAleer, MA, Jakasa, I, Hurault, G, Sarvari, P, McLean, WHI, Tanaka, RJ, Kezic, S, Irvine, AD

BACKGROUND: Biomarkers of atopic dermatitis (AD) are largely lacking, especially in infant AD. Those that have been examined to date have focused mostly on serum cytokines with few on non-invasive biomarkers in the skin. OBJECTIVES: We aimed to explo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::3ca47b0b4b2547819f4f325d41a70359
http://hdl.handle.net/10044/1/62001

Relationship and probabilistic stratification of EASI and oSCORAD severity scores for atopic dermatitis

Autor: Hurault, G, Schram, M, Roekevisch, E, Spuls, P, Tanaka, RJ

The Harmonizing Outcome Measures for Eczema (HOME) recommended the Eczema Area and Severity Index (EASI) as the core outcome instrument for measuring the clinical signs of atopic dermatitis (AD). However, EASI may not have been used in previous clini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::2bff1b98221cb4e07410bd4caae94c39
http://hdl.handle.net/10044/1/61265

Mathematical modeling of atopic dermatitis reveals 'double switch' mechanisms underlying 4 common disease phenotypes

Autor: Domínguez-Hüttinger, E, Christodoulides, P, Miyauchi, K, Irvine, AD, Okada-Hatakeyama, M, Kubo, M, Tanaka, RJ

Publikováno v: 1872.e7

Background: The skin barrier acts as the first line of defense against constant exposure to biological, microbial, physical and chemical environmental stressors. Dynamic interplay between defects in the skin barrier, dysfunctional immune responses, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::ad364177d66fb80e865f34bc9700569a
http://hdl.handle.net/10044/1/42181

Artificial Intelligence and Machine Learning in Dermatological Research and Healthcare: British Society for Investigative Dermatology Skin Club Report - Southampton April 2024.

Autor: Lai C; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong.; Dermatopharmacology, Clinical and Experimental Sciences, University of Southampton, Southampton, UK., Fuggle NR; MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK.; University Hospitals Southampton NHS Foundation Trust, Southampton, UK.; The Alan Turing Institute, London, UK., Matin RN; Dermatology Department, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Tanaka RJ; Department of Bioengineering, Imperial College London, London, UK., Banerji CRS; The Alan Turing Institute, London, UK.; University College London Hospital, University College London Hospitals NHS Trust, London, UK.; UCL Cancer Institute, Faculty of Medical Sciences, University College London, London, UK.; King's Comprehensive Cancer Centre, King's College London, London, UK., Rajan N; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.; Department of Dermatology, Newcastle upon Tyne NHS Foundation Trust, Newcastle upon Tyne, UK.

Publikováno v: The British journal of dermatology [Br J Dermatol] 2024 Oct 12. Date of Electronic Publication: 2024 Oct 12.

NETSKINMODELS: A European Network for Skin Engineering and Modeling.

Autor: Goreski H; Faculty of Electrical Engineering and Information Technologies, Ss. Cyril and Methodius University in Skopje, Skopje, North Macedonia., Ilic D; Stem Cell Laboratories, Guy's Assisted Conception Unit, Department of Women & Children's Health, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom., Flacher V; Laboratory CNRS I2CT/UPR3572 Immunology, Immunopathology and Therapeutic Chemistry, Strasbourg Drug Discovery and Development Institute (IMS), Institut de Biologie Moléculaire et Cellulaire, University of Strasbourg, Strasbourg, France., van den Bogaard E; Department of Dermatology, Radboud University Medical Center (Radboudumc), Radboud Institute for Molecular Life Sciences (RIMLS), Nijmegen, The Netherlands., Guttmann-Gruber C; EB House Austria, Research Program for Molecular Therapy of Genodermatoses, Department of Dermatology and Allergology, University Hospital of the Paracelsus Medical University, Salzburg, Austria., Tanaka RJ; Department of Bioengineering, Imperial College London, London, United Kingdom., Gülseren G; Department of Molecular Biology and Genetics, Konya Food and Agriculture University, Konya, Turkey., Marquette C; Plateforme 3D Fab, UMR 5246 CNRS Université de Lyon, INSA, CPE-Lyon, ICBMS, Villeurbanne, France., Fluhr J; Institute of Allergology, Charité - Universitätsmedizin Berlin, Berlin, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology, Allergology and Immunology, Berlin, Germany., Filor V; Department of Veterinary Medicine, Institute of Pharmacology and Toxicology, Freie Universität Berlin, Berlin, Germany., Sprincean S; Institute of Legal, Political and Sociological Research, State University of Moldova, Chișinău, Moldova., Dubrac S; Department of Dermatology, Venereology and Allergology, Medical University of Innsbruck, Innsbruck, Austria. Electronic address: cost21@i-med.ac.at.

Publikováno v: The Journal of investigative dermatology [J Invest Dermatol] 2024 Sep 03. Date of Electronic Publication: 2024 Sep 03.